Two-dimensional nanomaterials for biosensing applications

Su, Shao; Sun, Qian; Gu, Xiaodan; Xu, Yanbo; Shen, Jianlei; Zhu, Dan; Chao, Jie; Chen, Fan; Wang, Lianhui

doi:10.1016/j.trac.2019.07.021

Cited by 144 publications

(56 citation statements)

References 160 publications

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“…Although different kinds of nanomaterials have been used in medical biosensors, this section of the paper is exclusively confined to nanobiosensors based on TiO 2 nanostructures. [124][125][126] Recent interest in novel hybrid systems based on biomolecules and TiO 2 nanostructures has led to considerable success in the fabrication of bio-nano hybrid devices, such as biomolecule-sensitized solar cells (BSSCs) and photoelectrochemical cells (PECs). 127 Apart from these abovementioned devices, interfacing of biomolecules and TiO 2 nanostructured thin film has opened up a route for further developments in this area, including biosensors.…”

Section: Biosensors Based On Tiomentioning

confidence: 99%

Biomedical Applications of TiO2 Nanostructures: Recent Advances

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

277

116

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Titanium dioxide (TiO 2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO 2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO 2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies-like poor surface interaction with surrounding tissues-by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs-like osteoporosis drugs, anticancer and antibiotics-and used as local drug delivery systems. Furthermore, TiO 2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO 2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO 2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO 2 nanostructures, as well as its toxicity and biocompatibility, are presented.

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Section: Biosensors Based On Tiomentioning

confidence: 99%

Biomedical Applications of TiO2 Nanostructures: Recent Advances

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

277

116

View full text Add to dashboard Cite

show abstract

“…These structures are conventional oxide-electrolyte structure (only metal of MOS is removed, and an oxide layer is deposited), unmodified CMOS technology, floating gate, extended gate, double gate structures and top gated structures, which can be modified with different nanostructures and reinforced with materials (See Figure 3 ). These structures specifically or in a combination with other forms have been recognized as the basis for further development of other biological FET sensors such as graphene-FETs (GFETs), CNT-FETs, nanowire FETs (NW-FETs) or other novel sensing materials such as MoS2 and Metal-Organic Frameworks (MOFs) [ 39 , 40 , 41 , 42 , 43 ] (See Figure 4 ).…”

Section: Sensing Mechanism and Different Structures Of Chem/biofetsmentioning

confidence: 99%

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

et al. 2021

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Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum limit of detection (LoD) at the molecular level, integration with complementary metal oxide semiconductor (CMOS) technology and last but not least label-free operation were amongst the predominant motives for highlighting these sensors in the biosensor community. Although there are various diseases targeted by FET sensors for detection, infectious diseases are still the most demanding sector that needs higher precision in detection and integration for the realization of the diagnosis at the point of care (PoC). The COVID-19 pandemic, nevertheless, was an example of the escalated situation in terms of worldwide desperate need for fast, specific and reliable home test PoC devices for the timely screening of huge numbers of people to restrict the disease from further spread. This need spawned a wave of innovative approaches for early detection of COVID-19 antibodies in human swab or blood amongst which the FET biosensing gained much more attention due to their extraordinary LoD down to femtomolar (fM) with the comparatively faster response time. As the FET sensors are promising novel PoC devices with application in early diagnosis of various diseases and especially infectious diseases, in this research, we have reviewed the recent progress on developing FET sensors for infectious diseases diagnosis accompanied with a thorough discussion on the structure of Chem/BioFET sensors and the readout circuitry for output signal processing. This approach would help engineers and biologists to gain enough knowledge to initiate their design for accelerated innovations in response to the need for more efficient management of infectious diseases like COVID-19.

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“…In addition, nanomaterials have been widely used to construct electrochemical biosensors due to their advantages such as high conductivity, large specific surface area and good repeatability. [29] Advances in nanomaterials may provide an encouraging new approach to improve the sensitivity and selectivity of electrochemical biosensors. [30] As an element abundant in nature, carbon has been widely used in science and technology.…”

Section: Introductionmentioning

confidence: 99%

Recent Applications of Carbon Nanomaterials for microRNA Electrochemical Sensing

Wang

Wen

Yan

2020

Chemistry An Asian Journal

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MicroRNA (miRNA) is an important tumor marker in the human body, and its early detection has a great influence on the survival rate of patients. Although there are many detection methods for miRNA at present such as northern blotting, real‐time quantitative polymerase chain reaction, microarrays, and others, electrochemical biosensors have the advantages of low detection cost, small instrument size, simple operation, non‐invasive detection and low consumption of reagents and solvents, and thus they play an important role in the early detection of cancer. In addition, with the development of nanotechnology, nano‐biosensors show great potential. The application of various nanomaterials in the development of electrochemical biosensor has greatly improved the detection sensitivity of electrochemical biosensor. Among them, carbon nanomaterials which have unique electrical, optical, physical and chemical properties have attracted increasing attention. In particular, they have a large surface area, good biocompatibility and conductivity. Therefore, carbon nanomaterials combined with electrochemical methods can be used to detect miRNA quickly, easily and sensitively. In this review, we systematically review recent applications of different carbon nanomaterials (carbon nanotubes, graphene and its derivatives, graphitic carbon nitride, carbon dots, graphene quantum dots and other carbon nanomaterials) for miRNA electrochemical detection. In addition, we demonstrate the future prospects of electrochemical biosensors modified by carbon nanomaterials for the detection of miRNAs, and some suggestions for their development in the near future.

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Two-dimensional nanomaterials for biosensing applications

Cited by 144 publications

References 160 publications

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

Recent Applications of Carbon Nanomaterials for microRNA Electrochemical Sensing

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