Two-Dimensional Photoacoustic Imaging of Blood Vessel Networks within Biological Tissues

Su, Yixiong; Wang, Ke; Zhang, Fan; Yao, Jianquan

doi:10.1088/0256-307x/23/2/066

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…The delay-and-sum reconstruction algorithm [ 21 , 22 ] is a basic and widely used method in PACT. Most of the previous PACT studies on microvessels were focused on either imaging the distribution of microvessels [ [23] , [24] , [25] ] or quantifying hemoglobin oxygenation [ [26] , [27] , [28] ]. They were mainly interested in the amplitude of the time-domain photoacoustic (PA) signals.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic power azimuth spectrum for microvascular evaluation

et al. 2021

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The tubular structures and dendritic distributions of blood vessels emit anisotropic photoacoustic (PA) signals with different intensities and frequency components at different angles. Therefore, spectral analysis of PA signals from a single angle cannot accurately determine the physical characteristics of microvessels. This study investigated the feasibility of using the PA power azimuth spectrum (PA-PAS) method to evaluate microvessel structures. We mapped the acoustic power spectrum of the PA signals along the azimuth direction. Based on a frequency-domain analysis of the broadband PA signal, we calculated the spectral parameter power-weighted mean frequency (PWMF). The results demonstrate that the PA signal information of the microvessel is mainly concentrated in the direction of its width. In addition, the PWMF decreases linearly with the microvascular size. The experimental findings exhibit good agreement with the simulation results, thus demonstrating that this approach can effectively differentiate the sizes of microvessels.

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