Radial profiles of nuclear burn in directly-driven, inertial-confinement-fusion implosions have been systematically studied for the first time using a proton emission imaging system sensitive to energetic 14.7-MeV protons from the fusion of deuterium (D) and 3-helium ( 3 He) at the OMEGA laser facility [T. R. Boehly et al., Opt. Commun. 133, 495 (1997)]. Experimental parameters that were varied include capsule size, shell composition and thickness, gas fill pressure, and laser energy. Clear relationships have been identified between changes in a number of these parameters and changes in the size of the burn region, which we characterize here by the median "burn radius" R burn containing half of the total D 3 He reactions. Different laser and capsule parameters resulted in burn radii varying from 20 to 80 µm. For example, reducing the D 3 He fill pressure from 18 to 3.6 atm in capsules with 20-µm-thick CH shells resulted in the mean burn radius changing from 31 µm to 25 µm; this reduction is attributed to increased fuel-shell mix for the more unstable 3.6-atm implosions rather than to increased convergence, because total areal density didn't change very much. Fuel-shell-interface radii estimated from hard (4-5 keV) x-ray images of some of the same implosions were observed to closely track the burn radii. Simulated burn radii produced with 1-D codes agree fairly well with measurements for glass-shell capsules, but are systematically smaller than measurements for CH-shell capsules. A search for possible sources of systematic measurement error that could account for this discrepancy has been unsuccessful. Possible physical sources of discrepancies are mix, hydrodynamic instabilities and/or preheat not included in the 1-D code. Since measured burn-region sizes indicate where fusion actually occurs as a consequence of all the complicated processes that affect capsule implosion dynamics, they provide exacting tests of simulations. a) seguin@mit.edu b) Also Visiting Senior Scientist, Laboratory for Laser Energetics, University of Rochester. c) Also Departments of Mechanical Engineering, Physics and Astronomy, University of Rochester.Byline: ICF burn region measurements 2