We compared acoustic quantification (AQ) to Doppler echocardiography (DE) in the evaluation of left ventricular (LV) diastolic filling in 41hypertensives and 42 controls. In hypertensives, DE showed reduced ratios of early to late diastolic velocity, AQ revealed reduced peak to late filling rate ratios, and both techniques found prolonged acceleration times indicating abnormal filling. In 22 patients with mild hypertension and less LV hypertrophy, however, all DE filling parameters were normal. In these patients AQ indicated A nalysis of mitral inflow velocities as determined by pulsed Doppler echocardiography has been used for noninvasive assessment of left ventricular (LV) diastolic function.1-3 Doppler echocardiographic parameters of diastolic filling are functions of temporal pressure differences between left atrium and left ventricle. 4 They are determined not only by myocardial relaxation and compliance, but also by pericardial properties, ventricular interaction, age, heart rate, preload, and afterload. 5,6 Therefore, the Doppler mitral inflow profile is often inconclusive in the assessment of LV diastolic function. A commercially available acoustic quantification system of ultrasonic integrated backscatter has been introduced that provides on-line delineation of borders between blood and endocardium in two-dimensional imaging. 7,8 This novel technique allows on line tracking of the changing LV area over time. Also, a curve of the rate of area change (dA/dt) over time can be displayed. In sinus rhythm this curve shows an early and late diastolic peak corresponding to peak and late diastolic filling rate, which has been reported to permit characterization of LV diastolic filling. 9,10 However, the role of acoustic quantification in the diagnosis of diastolic dysfunction is still unclear. Therefore, we investigated whether acoustic quantification is useful in the investigation of diastolic filling in arterial hypertension and offers additional information in patients with inconclusive Doppler filling profiles.