Two distinct primary brain tumors, in same region of the same patient: a case report

First report of the simultaneous occurrence of choroid plexus papilloma and meningioma in a dog

“…In human medicine, since the first report in 1938, less than 150 cases have been described in the literature (Tugcu et al, 2006). To the author's knowledge, the presence of two different spontaneous primary brain tumours has been described in only three dogs so far (Stacy et al, 2003;Snyder et al, 2006;Mackillop et al, 2007).…”

“…As a result of modern imaging techniques, the diagnosis of cerebral neoplasia is increasing and therefore, the actual incidence is probably unknown (Bagley et al, 1999;Snyder et al, 2006). In human medicine, an association of multiple primary intracranial tumours of different histological types not relating to radiotherapy or phacomato-ses is a rare event (Maiuri et al, 2005;Tugcu et al, 2006). An annual incidence in the general population can be expected to be much less than 1 per million, solely based on the annual incidence rates of 10-15 cases per 100,000 who develop primary brain tumours (Zülch, 1986;Hassad and Al-Mefty, 1996).…”

Coexisting Pituitary Adenoma and Suprasellar Meningioma: A Coincidence or Causation Effect? Report of Two Cases and Review of Literature

“…K Suzuki et al in their Immunohistochemical analysis showed that concurrent adjacent double tumors occur because of activation of the signaling pathways of receptor tyrosine kinases (20). According to Tugcu B et al and Black et al (2006) one tumor may secrete a growth factor that initiates growth of another lesion (21,22). It is yet to be investigated whether in GH-producing adenoma, both the GH itself or the treating substance, such as Somatostatin, might induce arachnoid cap cell transformation to meningioma (23).…”

“…Most of the authors suggest that both tumors should be removed in one session (26). If removal of the tumors is not possible in one session, it is important to decide which tumor should be operated on first (22). YJ Lu et al (2007) suggested that avoiding the complications associated with the transcranial approaches, extended transsphenoidal surgery might be a good alternative choice for approaching suprasellar meningioma and pituitary adenoma simultaneously (20).…”

“…YJ Lu et al (2007) suggested that avoiding the complications associated with the transcranial approaches, extended transsphenoidal surgery might be a good alternative choice for approaching suprasellar meningioma and pituitary adenoma simultaneously (20). The ideal approach for treatment of such concomitant tumors is not clear due to lack of adequate experience in the literature (5,11,13,(22)(23)(24)(27)(28)(29)(30)(31)(32). Visual impairment was the main remaining complaint of both our patients after attempting to treat the PA either medically or surgically.…”