Two distinct types of dying back axonal degeneration in vitro

Abstract

This study describes two quite distinct types of dying back degeneration that lead an injured neurone to quite different fates.

Anterograde-propagation of axonal degeneration in the visual system of wlds mice characterized by diffusion tensor imaging

“…supports the idea that there are distinct axonal degeneration patterns, either with fragmentation or retraction steps during dying-back degeneration. These patterns were related to the survival or death of the neuronal cells (3). As such, different spatial patterns of axonal degeneration may represent pathways critical to neuronal fate in neurodegenerative conditions.…”

“…Damage to neuronal cell bodies or axons may trigger axonal degeneration, which can precipitate secondary degeneration along axons toward remote sites. Distinct patterns of degeneration exist and may depend upon the types of nerve fibers and initial causes of damage (3–5). Use of non-invasive tools to characterize patterns of degeneration in disease may provide useful insights into disease course and pathogenesis.…”

Regulation of axon arborization pattern in the developing chick ciliary ganglion: Possible involvement of caspase 3

“…; Öztürk et al . ). However, it was not involved in the fragmentation of degenerating axon (Öztürk et al .…”

“…However, it was not involved in the fragmentation of degenerating axon (Öztürk et al . ). The inhibition or knockdown of caspase 6 prevented the axon fragmentation of neurons induced by neurotrophic depletion, whereas the knockdown of caspase 3 did not (Nikolaev et al .…”

“…; Öztürk et al . ). These lines of evidence compelled us to consider whether the executioner caspases could be involved in the regulation of axon arborization during development.…”