Two-End Intimal Flap Suturing Method for Establishing Stanford B Type Aortic Dissection in a Canine Model

Cui, Jiasen; Zhuang, Shunjiu; Zhang, J.; Mei, Zhijun; Jing, Zaiping; Liao, Min

doi:10.1016/j.ejvs.2009.07.005

Cited by 13 publications

(17 citation statements)

References 6 publications

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“…15,[22][23][24][25][26] Most of the reported models had a limited dissection to the thoracic aorta 7,8,11,13 or did not specify the extension of the dissection (Table III). 6,9,12 In a dog model reported by Tang et al, three dissections out of 20 (15%) reach the renal aorta. Furthermore, this model was complex and time-consuming with a 25% rate of procedural failure as well as requiring an adrenaline injection with the risk of renal failure or intestinal necrosis.…”

Section: Discussionmentioning

confidence: 91%

“…Lately, several animal or physical models [5][6][7][8][9][10][11][12][13][14][18][19][20] of aortic dissection have been created to assess or improve current and new treatment methods for TBAD. However, these models have some limitations.…”

Section: Discussionmentioning

confidence: 99%

“…With this aim, several swine and dog models have been reported. [4][5][6][7][8][9][10][11][12][13][14] These models may have limitations, especially regarding the aortic diameter and distal extension of the dissection. Actually, in animal models, the dissection uncommonly reaches the infraceliac aorta, 10,14 whereas in humans, the infrarenal aorta is involved in up to 70% of the cases of TBAD.…”

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confidence: 99%

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Human ex-vivo model of Stanford type B aortic dissection

Faure

Canaud

Cathala

et al. 2014

Journal of Vascular Surgery

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This human ex vivo model of TBAD is reproducible, since, in all the aortas, extended dissection was achieved and provides the first model of human aortic dissection with infrarenal aorta extension allowing future assessment of endovascular devices developed for human use. Furthermore, it allows clarification of the patterns of aortic dissection propagation and visceral and renal artery involvement according to the site of the primary entry tear.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Human ex-vivo model of Stanford type B aortic dissection

Faure

Canaud

Cathala

et al. 2014

Journal of Vascular Surgery

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“…We are considering future studies that are based on proper animal models of aortic disease. In our preliminary studies, the model of descending aorta dissection has been achieved successfully in animals 17 . In principle, the application of this technique can be expanded to endovascular repair of the total aortic arch, leading to a wide range of therapeutic indications 4,5,18 .…”

Section: Discussionmentioning

confidence: 99%

Endovascular repair of the aortic arch in pigs by improved double-branched stent grafts

Chen

Wang

et al. 2013

annals

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IntroductionThis study aimed to evaluate the feasibility of total endovascular repair of the aortic arch in pigs using improved integrated double-branched stent grafts.MethodsImproved self-expandable stent grafts with a main body and two integrated branches were prepared for the repair of the aortic arch in six pigs. The feasibility of using these stent grafts was evaluated with arteriography, computed tomography (CT), computed tomography angiography (CTA) and autopsy three months following the procedure.ResultsThe double-branched stent grafts were placed successfully in the aortic arch in all six pigs. All pigs survived for at least three months and their biological behaviour was normal. Arteriography, CTA and animal necropsy revealed good fixation in all cases. Aortic valve function and coronary ostia remained intact, and CT of the head did not detect any lesion of cerebral infarction.ConclusionsEndovascular repair of the aortic arch with an integrated double-branched stent graft is safe and feasible in animal studies.

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“…In our preliminary studies, the model of descending aorta dissection has been successfully achieved in animals. 18,19 The presence of the dynamic forces in the thoracic aorta and aortic arch calls for further investigations on the long-term durability of our stent graft, although our autopsy did not reveal any stent graft fracture three months after the procedures.…”

Section: Limitations and Further Improvementsmentioning

confidence: 95%

Endovascular repair of the half aortic arch in pigs with an improved, single-branched stent graft system for the brachiocephalic trunk

Chen

Liao

et al. 2011

Vascular

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The objective of this study was to evaluate the feasibility of endovascular repair of half of the aortic arch in pigs using an improved, integrated, single-branched stent graft for the ascending aorta and brachiocephalic trunk (BCT). We designed an improved stent graft in an integrated fashion and deployed the stent grafts into the ascending aortas and BCT of eight pigs. The feasibility of the stent graft deployments was evaluated three months after the procedures using arteriography, computed tomography angiography (CTA) and animal autopsy. The stent grafts were successfully deployed in eight pigs. All animals survived for at least three months. Arteriography, CTA and animal necropsy revealed good stent fixation in eight cases. Their head CT scans found no evidence of cerebral infarction. In conclusion, endovascular repair of the half aortic arch with the integrated single-branched stent graft system appears to be safe and feasible in pigs.

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Two-End Intimal Flap Suturing Method for Establishing Stanford B Type Aortic Dissection in a Canine Model

Abstract: This model of aortic dissection using the two-end aortic intimal flap suturing method is similar to human Stanford type B aortic dissection.

Cited by 13 publications

References 6 publications

Human ex-vivo model of Stanford type B aortic dissection

Human ex-vivo model of Stanford type B aortic dissection

Endovascular repair of the aortic arch in pigs by improved double-branched stent grafts

Endovascular repair of the half aortic arch in pigs with an improved, single-branched stent graft system for the brachiocephalic trunk

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