This contribution underscores the importance of selecting an appropriate interphase momentum transfer model for accurately predicting the distribution of the solid phase in a full-scale circulating fluidized bed (CFB) riser equipped with a smooth C-type exit. It also explores other critical factors such as domain configuration, grid size, the scope of time averaging, and turbulence modulation. The flow in a cold-CFB riser is simulated using the Eulerian–Eulerian two-fluid model within a commercial CFD package. Particle interactions in the rapid-flow regime are determined utilizing the kinetic theory of granular flow while enduring particle contacts are accounted for by incorporating frictional stresses. The turbulent dynamics of the continuous phase are described using two-equation turbulence models with additional modulation terms. The three-dimensional computational domain replicates an actual CFB riser geometry where experimental measurements are available for particulate phase axial and radial solid concentration. The simulation results reveal that the choice of drag model correlation significantly impacts both axial and radial solid distribution. Notably, the energy-minimization multi-scale drag model accurately depicts the dense solid region at the bottom and core–annular flow structure in the upper part. The solid-phase fluidization is overestimated in the lower riser section when a 2D domain is utilized. Neglecting turbulence modulation terms in the k-ω SST model results in nearly flat solid volume fraction radial profiles in the analyzed upper sections of the riser, resembling those obtained with the k-ϵ model.