Two-generational effects and recovery of arsenic and arsenate on Daphnia magna in the presence of nano-TiO2

Fan, Wenhong; Liang, Dingyuan; Wang, Xiangrui; Ren, Jinqian; Xiao, Shengtao; Zhou, Tingting

doi:10.1016/j.ecoenv.2019.01.072

Cited by 27 publications

(10 citation statements)

References 39 publications

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“…Yang et al [24] observe that exposure of nSiO 2 significantly increases the cardiac toxicity of methylmercury (MeHg) in human cardiomyocytes and rat heart tissue. Besides, toxicity of As in Daphnia magna and fresh-water algae ( Microcystis aeruginosa and Scenedesmus obliquus ) was enhanced by TiO 2 nanoparticles [20,21].…”

Section: Resultsmentioning

confidence: 99%

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Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells

Ahamed

Akhtar

Alhadlaq

2019

IJERPH

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Widespread application of silica nanoparticles (nSiO2) and ubiquitous metalloid arsenic (As) may increase their chances of co-exposure to human beings in daily life. Nonetheless, studies on combined effects of nSiO2 and As in human cells are lacking. We investigated the co-exposure effects of nSiO2 and As in human liver (HepG2) and human fibroblast (HT1080) cells. Results showed that nSiO2 did not cause cytotoxicity. However, exposure of As caused oxidative stress and apoptosis in both types of cells. Interesting results were that co-exposure of a non-cytotoxic concentration of nSiO2 significantly augmented the As induced toxicity in both cells. Intracellular level of As was higher in the co-exposure group (nSiO2 + As) than the As group alone, suggesting that nSiO2 facilitates the cellular uptake of As. Co-exposure of nSiO2 and As potentiated oxidative stress indicated by pro-oxidants generation (reactive oxygen species, hydrogen peroxide and lipid peroxidation) and antioxidants depletion (glutathione level, and glutathione reductase, superoxide dismutase and catalase activities). In addition, co-exposure of nSiO2 and As also potentiated mitochondria-mediated apoptosis suggested by increased expression of p53, bax, caspase-3 and caspase-9 genes (pro-apoptotic) and decreased expression of bcl-2 gene (anti-apoptotic) along with depleted mitochondrial membrane potential. To the best of our knowledge, this is the first study showing that co-exposure of nSiO2 and As induced augmentation of oxidative stress and mitochondria-mediated apoptosis in HepG2 and HT1080 cells. Hence, careful attention is required for human health assessment following combined exposure to nSiO2 and As.

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Section: Resultsmentioning

confidence: 99%

“…However, toxicity of As might largely be affected by several environmental factors including organic matters, colloids and presence of nanoparticles [18,19]. Therefore, these factors should be taken account while evaluating the toxicity of As [20,21].…”

Section: Introductionmentioning

confidence: 99%

Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells

Ahamed

Akhtar

Alhadlaq

2019

IJERPH

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“…It is well known that, in reality, species can be exposed to contaminants not only throughout their entire life but also over many generations, which may have a greater impact on the population [121]. Thus, despite many short-term studies assessing NPs and/or HMs exposure outcomes [69,79,80], several studies have evaluated the impacts of the individual or mutual NP and HM long-term or multigenerational exposure [122][123][124][125]. It was evident that the outcomes of the co-exposure to NPs and HMs during the parental generation can affect the health of offspring in various ways.…”

Section: Discussionmentioning

confidence: 99%

Effects of Co-Exposure of Nanoparticles and Metals on Different Organisms: A Review

Abd‐Elhakim

Hashem

Abo‐EL‐Sooud

et al. 2021

Toxics

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Wide nanotechnology applications and the commercialization of consumer products containing engineered nanomaterials (ENMs) have increased the release of nanoparticles (NPs) to the environment. Titanium dioxide, aluminum oxide, zinc oxide, and silica NPs are widely implicated NPs in industrial, medicinal, and food products. Different types of pollutants usually co-exist in the environment. Heavy metals (HMs) are widely distributed pollutants that could potentially co-occur with NPs in the environment. Similar to what occurs with NPs, HMs accumulation in the environment results from anthropogenic activities, in addition to some natural sources. These pollutants remain in the environment for long periods and have an impact on several organisms through different routes of exposure in soil, water, and air. The impact on complex systems results from the interactions between NPs and HMs and the organisms. This review describes the outcomes of simultaneous exposure to the most commonly found ENMs and HMs, particularly on soil and aquatic organisms.

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“…Acute and chronic exposure of Tigriopus japonicus to mixtures of ZnONPs and Cd(II) or Pb(II) resulted in the contrasting effects [104]. However, chronic exposure of Daphnia magna to mixture of TiO 2 NPs and As(III)/As(V) led to comparable toxicity [105].…”

Section: Toxicity Of Mixtures Of Enps and Metallic Pollutants To Aquamentioning

confidence: 99%

Effects of Mixtures of Engineered Nanoparticles and Metallic Pollutants on Aquatic Organisms

Liu

Slaveykova

2020

Environments

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In aquatic environment, engineered nanoparticles (ENPs) are present as complex mixtures with other pollutants, such as trace metals, which could result in synergism, additivity or antagonism of their combined effects. Despite the fact that the toxicity and environmental risk of the ENPs have received extensive attention in the recent years, the interactions of ENPs with other pollutants and the consequent effects on aquatic organisms represent an important challenge in (nano)ecotoxicology. The present review provides an overview of the state-of-the-art and critically discusses the existing knowledge on combined effects of mixtures of ENPs and metallic pollutants on aquatic organisms. The specific emphasis is on the adsorption of metallic pollutants on metal-containing ENPs, transformation and bioavailability of ENPs and metallic pollutants in mixtures. Antagonistic, additive and synergistic effects observed in aquatic organisms co-exposed to ENPs and metallic pollutants are discussed in the case of “particle-proof” and “particle-ingestive” organisms. This knowledge is important in developing efficient strategies for sound environmental impact assessment of mixture exposure in complex environments.

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Two-generational effects and recovery of arsenic and arsenate on Daphnia magna in the presence of nano-TiO2

Cited by 27 publications

References 39 publications

Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells

Co-Exposure to SiO2 Nanoparticles and Arsenic Induced Augmentation of Oxidative Stress and Mitochondria-Dependent Apoptosis in Human Cells

Effects of Co-Exposure of Nanoparticles and Metals on Different Organisms: A Review

Effects of Mixtures of Engineered Nanoparticles and Metallic Pollutants on Aquatic Organisms

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