Two hands, one brain, and aging

Maes, Celine; Gooijers, Jolien; Xivry, Jean-Jacques Orban de; Swinnen, Stephan P.; Boisgontier, Matthieu P.

doi:10.1016/j.neubiorev.2017.01.052

Cited by 104 publications

(103 citation statements)

References 145 publications

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“…Further, the relatively small number of participants in each group may have contributed to low statistical power and an inability to detect significant group differences. While results reported here are consistent with previous fMRI and EEG studies with larger sample sizes (Maes et al, ; Sala‐Llonch, Bartrés‐Faz, & Junqué, ), reproducibility of our findings should be assessed in a similar, but larger, cohort of young and elderly individuals. Lastly, our choice of processing pipeline may have precluded the identification of modulatory effects that were not time‐locked to the production of isometric handgrips.…”

Section: Discussionsupporting

confidence: 92%

“…Advancing age is associated with decreased cognitive and motor performance in humans (Enoka et al, ; Seidler et al, ). Motor decline often affects skills that are necessary to perform many daily life tasks as, for instance, hand motor control (e.g., reaching and grasping objects), bimanual coordination (e.g., tying shoelaces), as well as gait and balance (e.g., walking; Maes, Gooijers, de Xivry, Swinnen, & Boisgontier, ; Seidler et al, ). With an ever‐increasing aging society (Krueger et al, ), identifying the neural correlates underpinning the deterioration of motor control has become a primary focus of research (Song et al, ; Tomasi & Volkow, ).…”

Section: Introductionmentioning

confidence: 99%

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Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements

Larivière

Xifra‐Porxas

Kassinopoulos

et al. 2019

Human Brain Mapping

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Motor performance decline observed during aging is linked to changes in brain structure and function, however, the precise neural reorganization associated with these changes remains largely unknown. We investigated the neurophysiological correlates of this reorganization by quantifying functional and effective brain network connectivity in elderly individuals (n = 11; mean age = 67.5 years), compared to young adults (n = 12; mean age = 23.7 years), while they performed visually‐guided unimanual and bimanual handgrips inside the magnetoencephalography (MEG) scanner. Through a combination of principal component analysis and Granger causality, we observed age‐related increases in functional and effective connectivity in whole‐brain, task‐related motor networks. Specifically, elderly individuals demonstrated (i) greater information flow from contralateral parietal and ipsilateral secondary motor regions to the left primary motor cortex during the unimanual task and (ii) decreased interhemispheric temporo‐frontal communication during the bimanual task. Maintenance of motor performance and task accuracy in elderly was achieved by hyperactivation of the task‐specific motor networks, reflecting a possible mechanism by which the aging brain recruits additional resources to counteract known myelo‐ and cytoarchitectural changes. Furthermore, resting‐state sessions acquired before and after each motor task revealed that both older and younger adults maintain the capacity to adapt to task demands via network‐wide increases in functional connectivity. Collectively, our study consolidates functional connectivity and directionality of information flow in systems‐level cortical networks during aging and furthers our understanding of neuronal flexibility in motor processes.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Functional and effective reorganization of the aging brain during unimanual and bimanual hand movements

Larivière

Xifra‐Porxas

Kassinopoulos

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

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“…This finding is partly consistent with previous research that has found little age-related slowing in synchronous bimanual reaching movements (Maes et al, 2017). This finding is partly consistent with previous research that has found little age-related slowing in synchronous bimanual reaching movements (Maes et al, 2017).…”

Section: Age-related Differences In the Bimanual Tasksupporting

confidence: 92%

“…A search in the literature shows that most studies of bimanual movements have used tasks like circle tracing or finger tapping (Maes, Gooijers, de Xivry, & Swinnen, 2017), which are of little relevance for daily actions that require manipulation of objects. Therefore, it is beneficial to combine both approaches to thoroughly characterize possible agerelated declines in hand function associated with daily activities.…”

Section: Introductionmentioning

confidence: 99%

“…At present, there are limited investigations of bimanual object manipulation relevant for real life activities. A search in the literature shows that most studies of bimanual movements have used tasks like circle tracing or finger tapping (Maes, Gooijers, de Xivry, & Swinnen, 2017), which are of little relevance for daily actions that require manipulation of objects.…”

Section: Introductionmentioning

confidence: 99%

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Manual dexterity in young and healthy older adults. 1. Age‐ and gender‐related differences in unimanual and bimanual performance

Vasylenko

Gorecka

Rodríguez‐Aranda

2018

Developmental Psychobiology

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This study aimed to better characterize age-related differences in dexterity by using an integrative approach where movement times and kinematics were measured for both hands. Forty-five young (age 19-31) and 55 healthy older adults (age 60-88) were evaluated during unimanual and bimanual performance of the Purdue Pegboard Test. Gender effects were also assessed. From video-recorded data, movement times and kinematics were obtained for reaching, grasping, transport, and inserting. Results showed that older adults had longer movement times for grasping and inserting with the right hand, and across all movements with the left hand. Kinematic differences were found in path length, linear, and angular velocity. The patterns of slowing were similar in unimanual and bimanual tasks. Gender effects showed more slowing in older males than older females. Age differences in dexterity not only comprise slowing of movements but also kinematic alterations. The importance of gender in hand function was demonstrated.

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