Two immune-enhanced molecular subtypes differ in inflammation, immune checkpoints, mutations and outcome in Stage I-II colonic carcinoma.

Abstract

Background: The purpose of this paper is to investigate the immune function of the tumor microenvironment and its clinical correlation with colonic carcinoma. Methods : Immune genes were downloaded from the The Cancer Genome Atlas （TCGA）database. Five subtypes are obtained by cluster screening based on immune gene expression data. Results: The C3 and C4 subtypes show stronger immune activity. In addition, the C4 subtype has the largest number of gene mutations and the worst prognosis. Most of the immune signatures are upregulated in the C4 subtype, while most of the immune infiltration-related cells are upregulated in the C3 and C4 subtypes. Conclusions: The different immune microenvironments between these subtypes may provide new ideas for immunotherapy strategies in colon carcinoma.