Two new bisindole alkaloids from the seeds of Strychnos nux-vomica

Yang, Guangming; Tu, Xia; Liu, Liangjing; Pan, Yang

doi:10.1016/j.fitote.2010.06.009

Cited by 7 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nux vomica has been used as a traditional Chinese medicine for a long history, which is reported to have a remarkable effect in improving circulatory system and relieving arthritic and traumatic pains (Fu et al, ). The research shows that the main active ingredients of nux vomica are alkaloids, such as strychnine and brucine, and which are widely used in clinical treatment of various of tumors (Rao, Ramanadham, & Prasad, ; Saraswati & Agrawal, ; Yang, Tu, Liu, & Pan, ). However, the mechanism underlying the antitumor property of the alkaloids remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β‐catenin signaling pathway

Ren

Zhao

Fan

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Brucine and Strychnine are alkaloids isolated from the seeds of Strychnos nux vomica L., which have long been used as a traditional medicine for the treatment of tumor. However, the effect of Brucine and Strychnine on colorectal cancer (CRC) and the underlying molecular mechanism remain unclear. In the present study, Brucine and Strychnine displayed profound inhibitory effects on the growth of human colon cancer cells. The results of flow cytometric analysis demonstrated that the two alkaloids induced cellular apoptosis. Moreover, the growth of DLD1 xenografted tumors in nude mice was significantly suppressed in the Brucine or Strychnine treated group. Mechanistically, the Wnt/β‐catenin is involved in this phenomenon, which is characterized by significantly increased expression of DKK1 and APC, whereas decreased expression of β‐catenin, c‐Myc, and p‐LRP6 in CRC cells as well as tumor tissues. Collectively, Brucine and Strychnine have targeted inhibition for colon cancer proliferation both in vitro and in vivo, and it is valuable for future exploitation and utilization as an antitumor agent of CRC.

show abstract

Section: Introductionmentioning

confidence: 99%

Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β‐catenin signaling pathway

Ren

Zhao

Fan

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…1) take up about 70%. Recently, another two new bisindole alkaloids, named 4-N-hydroxymethyl strychnidin-17-acetic acid and 10, 11-dimethoxy-4-N-hydroxymethyl strychnidin-17-acetic acid, have been identified from nux vomica (Yang et al, 2010). Strychnine, the most abundant alkaloid constituent of nux vomica (40-50%), is well known to be a deadly poison.…”

Section: Introductionmentioning

confidence: 99%