Two New Compounds from the Leaves of Calocedrus microlepic var. formosana

Chien, Shih‐Chang; Liu, Han‐Kang; Kuo, Yueh‐Hsiung

doi:10.1248/cpb.52.762

Cited by 25 publications

(5 citation statements)

References 11 publications

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“…Like other phytochemicals, separation and isolation of amentoflavone were mainly performed with conventional thin layer chromatography [ 23 , 24 ] and column chromatography, in which silica gel [ 15 , 18 , 25 ], polyamide [ 16 ], macroporous adsorption resin [ 85 , 86 ], octadecyl silane [ 11 , 22 ], middle chromatogram isolation (MCI) gel [ 51 ], and gel (Sephadex LH-20) [ 12 , 13 , 27 ] were used as stationery phases. In most cases, some of the above methods were combined for use [ 51 , 63 , 82 , 88 , 115 , 137 ].…”

Section: Extraction and Isolationmentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.

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Section: Extraction and Isolationmentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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“…The NMR spectral data of 4 were similar to those of 3 except the additional signals of a methoxy group (δ C 57.0 and δ H 3.57) attached on C-15 (δ C 102.5). By means of the analysis of NMR spectra and comparing with the data in the reference [11] 1H, s, H-17b). These spectral characteristics revealed that compound 5 was a Δ 8,17labdane.…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents and their biological activity of Pinus dalatensis. Part 1. Terpenoids from the leaves

H.¹,

Tâm²,

Quân³

et al. 2017

VJChem

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Seven terpenoids were isolated from the dried leaves of Pinus dalatensis Ferré, including one caryolane sesquiterpenoid (1), five labdane diterpenoids (2, 3, 4, 5, 6) and one serratane triterpenoid (7). The structures of the isolated compounds were determined on the basic of spectroscopic methods (ESI-MS, NMR) and comparison with reported data. Among these compounds, the mixture of compounds 2 and 3 showed inhibitory effects on the growth of acute myeloid leukemia (OCI-AML) cells. This is the first report on the chemical compositions of Pinus dalatensis in Vietnam.

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“…The chemical structures of the pure compounds isolated from P. orientalis extract were determined by spectroscopic analyses and compared with the spectroscopic data of compounds previously described in the literatures [ 19 , 21 , 22 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. The NMR experiments were carried out on a Bruker Advance Spectrometer (Burker BioSpin, Rheinstetten, Germany) at 500 MHz for proton( 1 H) and 125 MHz for carbon-13 ( 13 C) in CDCl 3 (Cambridge Isotope Laboratories, Tewksbury, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Plant Disease Control Efficacy of Platycladus orientalis and Its Antifungal Compounds

Bae

Han

Dang³

et al. 2021

Plants

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Plants contain a number of bioactive compounds that exhibit antimicrobial activity, which can be recognized as an important source of agrochemicals for plant disease control. In searching for natural alternatives to synthetic fungicides, we found that a methanol extract of the plant species Platycladus orientalis suppressed the disease development of rice blast caused by Magnaporthe oryzae. Through a series of chromatography procedures in combination with activity-guided fractionation, we isolated and identified a total of eleven compounds including four labdane-type diterpenes (1–4), six isopimarane-type diterpenes (5–10), and one sesquiterpene (11). Of the identified compounds, the MIC values of compounds 1, 2, 5 & 6 mixture, 9, and 11 ranged from 100 to 200 μg/mL against M. oryzae, whereas the other compounds were over 200 μg/mL. When rice plants were treated with the antifungal compounds, compounds 1, 2, and 9 effectively suppressed the development of rice blast at all concentrations tested by over 75% compared to the non-treatment control. In addition, a mixture of compounds 5 & 6 that constituted 66% of the P. orientalis ethyl acetate fraction also exhibited a moderate disease control efficacy. Together, our data suggest that the methanol extract of P. orientalis including terpenoid compounds has potential as a crop protection agent.

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Two New Compounds from the Leaves of Calocedrus microlepic var. formosana

Cited by 25 publications

References 11 publications

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Chemical constituents and their biological activity of Pinus dalatensis. Part 1. Terpenoids from the leaves

Plant Disease Control Efficacy of Platycladus orientalis and Its Antifungal Compounds

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