Two new glucoside derivatives of truxinic and cinnamic acids from <i>Lavandula angustifolia</i> mill

Ablikim, Gulnigar; Бобакулов, Х. М.; Li, Jun; Yadikar, Nigary; Aisa, Haji Akber

doi:10.1080/14786419.2019.1684283

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Hydroxycinnamic acids are common phenolic acids within plant species and are generally derived from cinnamic acid [30]. These natural compounds can be found as their esters, glycosides, and/or conjugated with proteins [31,32]. The utmost common hydroxycinnamic acids derivatives are caffeic acid, ferulic acid, and coumaric acid, as shown in their chemical structure in Figure 1 [25].…”

Section: Simple Phenols and Phenolic Acidsmentioning

confidence: 99%

Preventing Microbial Infections with Natural Phenolic Compounds

Ecevit

Barros

Silva

et al. 2022

Future Pharmacology

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The struggle between humans and pathogens has taken and is continuing to take countless lives every year. As the misusage of conventional antibiotics increases, the complexity associated with the resistance mechanisms of pathogens has been evolving into gradually more clever mechanisms, diminishing the effectiveness of antibiotics. Hence, there is a growing interest in discovering novel and reliable therapeutics able to struggle with the infection, circumvent the resistance and defend the natural microbiome. In this regard, nature-derived phenolic compounds are gaining considerable attention due to their potential safety and therapeutic effect. Phenolic compounds comprise numerous and widely distributed groups with different biological activities attributed mainly to their structure. Investigations have revealed that phenolic compounds from natural sources exhibit potent antimicrobial activity against various clinically relevant pathogens associated with microbial infection and sensitize multi-drug resistance strains to bactericidal or bacteriostatic antibiotics. This review outlines the current knowledge about the antimicrobial activity of phenolic compounds from various natural sources, with a particular focus on the structure-activity relationship and mechanisms of actions of each class of natural phenolic compounds, including simple phenols, phenolic acids, coumarin, flavonoids, tannins, stilbenes, lignans, quinones, and curcuminoids.

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Section: Simple Phenols and Phenolic Acidsmentioning

confidence: 99%

Preventing Microbial Infections with Natural Phenolic Compounds

Ecevit

Barros

Silva

et al. 2022

Future Pharmacology

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“…Furthermore, trans-GMCA, GMPPA as well as 4,4 -dimethoxy-2,2 -di-O-hexoside-truxinate were previously identified in n-butanol fraction from aerial parts of Lavandula angustifolia Mill. [19] HIh-PE contained a variety of 3-hydroxy-3-methylglutaric (HMG) acid conjugates with quercetin (peak 22), 7-O-methylquercetin (peak 31), kaempferol (peaks 24, 28), and 7-Omethylkaempferol (peaks [33][34][35][36][37]. Three non-phenolic metabolites: maltol derivative (LB), N-malonyl-tryptophan (peak 14), and a trace amount of blumenin isomer (peak 23) were also identified in these extracts.…”

Section: Phytochemical Profiles and The Content Of Individual Phenoli...mentioning

confidence: 99%

Comparison of Phenolic Metabolites in Purified Extracts of Three Wild-Growing Herniaria L. Species and Their Antioxidant and Anti-Inflammatory Activities In Vitro

et al. 2022

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The work is aimed at phytochemical characterization and In Vitro evaluation of antioxidant actions, anti-inflammatory effects, and cytotoxicity of purified extracts from three rupturewort (Herniaria L.) species, i.e., Herniaria glabra (HG), H. polygama (HP), and H. incana herb (HIh). The total phenolic content established in the purified extracts (PEs) of HIh, HP, and HG was 29.6, 24.0, and 13.0%, respectively. Thirty-eight non-saponin metabolites were identified using LC-HR-QTOF-ESI-MS; however, only 9 were common for the studied Herniaria species. The most abundant phenolic compound in HG-PE was narcissin (7.4%), HP-PE shared 3 major constituents, namely cis-2-hydroxy-4-methoxycinnamic acid 2-O-β-glucoside (cis-GMCA, 5.8%), narcissin (5.4%), and rutin (5.3%). Almost half of HIh phenolic content (14.7%) belonged to oxytroflavoside A (7-O-methylkaempferol-3-O-[3-hydroxy-3-methylglutaryl-(1→6)]-[α-rhamnopyranosyl-(1®2)]-β-galactopyranoside). Antioxidant properties of the Herniaria PEs were evaluated employing an experimental model of human blood plasma, exposed to the peroxynitrite-induced oxidative stress. The assays demonstrated significant reduction of oxidative damage to protein and lipid plasma components (estimated by measurements of 3-nitrotyrosine, protein thiol groups, thiobarbituric acid-reactive substances), and moderate protection of its non-enzymatic antioxidant capacity. Anti-inflammatory properties of the Herniaria PEs were evaluated In Vitro as inhibitory effects against cyclooxygenases (COX-1 and -2) and concanavalin A-induced inflammatory response of the peripheral blood mononuclear cells (PBMCs). None of the studied plants showed inhibitory effects on COXs but all purified extracts partly reduced the release of interleukin 2 (IL-2) and tumor necrosis factor-alpha (TNF-α) from PBMCs, which suggested their prospective ability to up-regulate inflammatory response of the cells. The purified extract from H. glabra turned out to be the most efficient suppressor of PBMCs’ inflammatory response. Additionally, cytotoxicity of purified Herniaria extracts on PBMCs was ruled out based on In Vitro studies.

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“…These compounds are renowned for their pharmacological activities, such as D-glucose (anti-cancer and anti-diabetic activities) [ 24 , 25 ], hydroxyphenyl (reproduction and the endocrine system) [ 26 ], D-Ribofuranose (anti-inflammatory activity) [ 27 ] and myo-inositol (male and female fertility) [ 28 , 29 ]. Other studies revealed the presence of certain compounds in the hydro-ethanolic extract of lavender, such as malic acid [ 30 ], mannose and glucose [ 31 ], and cinnamic acid [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

The LC-MS/MS Identification and Analgesic and Wound Healing Activities of Lavandula officinalis Chaix: In Vivo and In Silico Approaches

Slighoua

Chebaibi

Mahdi

et al. 2022

Plants

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We earlier emphasized in vivo the lavender plant’s (Lavandula officinalis Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico. The analgesic activity was studied using two methods: acetic acid and formalin injections in mice. The wound-healing activity was carried out over 25 days using a burn model in rats. In the in silico study, the polyphenols identified in the plant were docked in the active sites of three enzymes: casein kinase-1, cyclooxygenase-2, and glycogen synthase kinase-3β. The LC-MS/MS identified some phenolic compounds, mainly apigenin, catechin, and myricetin, and the GC-MS analysis revealed the presence of 19 volatile compounds with triazole, D-glucose, hydroxyphenyl, and D-Ribofuranose as the major compounds. The HE and LOP extracts showed significant decreases in abdominal writhes, and the higher licking time of the paw (57.67%) was observed using the LOP extract at 200 mg/kg. Moreover, both extracts showed high healing percentages, i.e., 99.31 and 92.88%, compared to the control groups, respectively. The molecular docking showed that myricetin, amentoflavone, apigenin, and catechin are the most active molecules against the three enzyme receptors. This study sheds light on the potential of L. officinalis Chaix as a source of natural products for pharmaceutical applications for analgesic purposes as well as their utility in promoting burn-healing activity.

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Two new glucoside derivatives of truxinic and cinnamic acids from Lavandula angustifolia mill

Cited by 7 publications

References 19 publications

Preventing Microbial Infections with Natural Phenolic Compounds

Preventing Microbial Infections with Natural Phenolic Compounds

Comparison of Phenolic Metabolites in Purified Extracts of Three Wild-Growing Herniaria L. Species and Their Antioxidant and Anti-Inflammatory Activities In Vitro

The LC-MS/MS Identification and Analgesic and Wound Healing Activities of Lavandula officinalis Chaix: In Vivo and In Silico Approaches

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