Two New Glycosides from the Whole Plants of Glechoma hederacea L.

Abstract

Two new glycosides, 7S,7S,8R,8R-icariol

Chemical Constituents from the Leaves and Stems of Schisandra lancifolia

“…From these functionalities, the aglycone suggested a 2,5-diaryltetrahydrofuranoid-type lignan. 29,30) In addition, HMBC correlations from the protons of one methoxyl group (d H 3.83, 3H, s) to C-3 (d C 148.4) showed that the methoxyl group was located at C-3, which was further confirmed by the ROESY correlation of the methoxyl group protons with H-2. HMBC correlations of protons of one methylenedioxy group with C-3Ј and C-4Ј determined the methylenedioxy group was located between C-3Ј and C-4Ј.…”

“…Compound 1 gave a quasi-molecular ion at m/z 599 [MϩNa] ϩ in its positive electrospray ionization (ESI)-MS spectrum and possessed a molecular formula of C 29 C-NMR data of 1 revealed that they are similar to those reported for micrandilactone D (4), 18,19) which was also isolated in this plant. Comparison of 1D NMR data, together with detailed HMBC and The relative stereochemistry of 1 was established by analysis of its ROESY NMR data and chemical shift comparison with those of micrandilactone D. 18,19) Biogenetically, H-C(5) was a-and Me(18) was b-oriented.…”

“…HMBC correlations of protons of one methylenedioxy group with C-3Ј and C-4Ј determined the methylenedioxy group was located between C-3Ј and C-4Ј. The hexose was deduced to be glucose by the comparison of chemical shifts of sugar unit with those of 7S,7ЈS,8R,8ЈR-icariol A 2 -9-O-b-D-glucopyranoside, 29) and was further confirmed by acid hydrolysis of 2, which afforded D-glucose. The glucose was unambiguously assigned to C-9 (d C 69.4) due to the obvious 1 H-…”

Anti-Melanogenesis Effect ofGlechoma hederaceaL. Extract on B16 Murine Melanoma Cells

“…Several studies have reported that the chemical composition of G. hederacea includes alkaloids, sesquiterpenoids, triterpenoids, flavonoid glycosides, and rosmarinic acid, [20][21][22][37][38][39] but there is no report on the active constituent of G. hederacea as to anti-melanogensis. Further work is needed to define it.…”

“…20) It has been used as a folk medicine for centuries in the treatment of various ailments, e.g., asthma, bronchitis, colds, diabetes, and inflammation. 21) In addition, it has been reported that G. hederacea extract has anti-oxidant activity, 22) but no report on melanin biosynthesis or tyrosinase activity has been demonstrated. Hence we focused on the whitening effect y To whom correspondence should be addressed.…”