Two new guaiane sesquiterpene lactones from the aerial parts of Artemisia vulgaris

Abstract

Two new guaiane sesquiterpene lactones, vulgarolides A and B (1 and 2), were isolated from Artemisia vulgaris aerial parts using various chromatographic separations. The structure elucidation was performed by combination of spectroscopic experiments including 1D and 2D NMR, HR ESI MS, and CD. Their in vitro cytotoxic activities against five human cancer cell lines were also evaluated using SRB method.

Перспективные Источники Природных Терпеноидов

“…Similarly, two new guaiane sesquiterpene lactones were isolated from Artemisia vulgaris aerial parts. A combination of spectroscopic tests, including 1D and 2D NMR, CD, and HR ESI MS, were used to deduce the structure of sesquiterpene lactones, vulgarolides A (20) and B (21), in Figure 7. The sulforhodamine B colorimetric assay was used to assess theirs in vitro cytotoxic capabilities against five human cancer cell lines [21].…”

“…A combination of spectroscopic tests, including 1D and 2D NMR, CD, and HR ESI MS, were used to deduce the structure of sesquiterpene lactones, vulgarolides A (20) and B (21), in Figure 7. The sulforhodamine B colorimetric assay was used to assess theirs in vitro cytotoxic capabilities against five human cancer cell lines [21]. It is known that this herb is widely grown in Vietnam and has been used in folk medicine to treat metrorrhagia, the threat of pregnancy loss, menstrual abdominal pain, and irregular menstruation [22].…”