Two New Lactones with Mosquito Larvicidal Activity from Three <i>Hortonia</i> Species

Ratnayake, Rukmal; Karunaratne, Veranja; Bandara, B. M. Ratnayake; Kumar, Vijaya; MacLeod, John K.; Simmonds, P. M.

doi:10.1021/np000371t

Cited by 43 publications

(33 citation statements)

References 7 publications

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“…Lactones, organic cyclic esters, have been also investigated as mosquito larvicides. Two lactones isolated from Hortonia species were able to kill A. aegypti larvae (Ratnayake et al, 2001) and a dehydrocostus lactone isolated from Saussurea lappa essential oil showed strong larvicidal activity (LC50: 2.34 μg/mL) against Aedes albopictus (Liu et al, 2012). Some lactones have been reported as oviposition attractants such as the erythro-6-acetoxy-5-hexadecanolide, which is the major component of oviposition pheromone released in egg droplets of Culex quinquefasciatus .…”

Section: Introductionmentioning

confidence: 99%

Effects of α,β-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti

Barros

Freitas

Santos

et al. 2015

Experimental Parasitology

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Lactones are organic cyclic esters that have been described as larvicides against Aedes aegypti and as components of oviposition pheromone of Culex quinquefasciatus. This work describes the effect of six α,β-unsaturated lactones (5a-5f) on survival of A. aegypti fourth instar larvae (L4). It is also reported the effects of the lactones on L4 gut trypsin activity and oviposition behavior of A. aegypti females. Five lactones were able to kill L4 being the lactones 5a (LC50 of 39.05 ppm), 5e (LC50 of 36.30 ppm) and 5f (LC50 of 40.46 ppm) the most promising larvicides. Only the lactone 5a inhibited L4 gut trypsin activity, with an IC50 of 115.15 µg/mL. Lactones 5a, 5c, 5d and 5e did not exert deterrent or stimulatory effects on oviposition, whereas lactone 5b exhibited a strong deterrent oviposition activity. In conclusion, this work introduces new α,β-unsaturated lactones as promising alternatives to control A. aegypti dissemination. The larvicidal mechanism of the lactone 5a can involve the disruption of proteolysis at larval gut.

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Section: Introductionmentioning

confidence: 99%

Effects of α,β-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti

Barros

Freitas

Santos

et al. 2015

Experimental Parasitology

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“…Naturally derived biocides, such as plant extracts, have received increased attention, and nowadays, more than 2,000 plant species have already been screened as potent insecticides, providing possible candidates to replace the synthetic chemical insecticides particularly for controlling mosquito larvae (El Hag et al 1999;Rahuman et al 2000;Ratnayake et al 2001;Mongelli et al 2002;Trabousli et al 2002Trabousli et al , 2005Yang et al 2002Yang et al , 2003Jeyabalan et al 2003;Cheng et al 2004;Joseph et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens

et al. 2008

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Concentration-dependent mortality effects were observed for three pure synthetic natural products (alkannin, shikonin, and shikalkin) and three acetylated derivatives of shikonin against Culex pipiens (Culicidae: Diptera) for the first time. The larvicidal properties of all naphthoquinones were evaluated under laboratory conditions against the larvae of the mosquito species C. pipiens biotype molestus, the anthropophilic biotype of the C. pipiens mosquito species. Experimental data of the tested toxicity of quinones revealed generally high efficacy where shikonin (3.9 mg/L) was the most active followed by shikalkin (8.73 mg/L) and alkannin (12.35 mg/L). The insecticidal performance of shikonin-acetylated derivatives was also investigated, aiming at the same time in the establishment of the relationships between the structure and the activity of shikonin-type compounds with larvicidal activity against C. pipiens. Results indicated that naphthoquinones, compared with other natural compounds with larvicidal activity, are very toxic against mosquito larvae and could be a potential source of natural larvicidal substances. Finally, bioassays with shikonin derivatives also revealed that although hydroxylic groups seem to play a secondary role in efficacy, the quinone moiety is essential.

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“…On 1991 Sukumar et al [12] reviewed the use of natural products derived from 344 different plant species to control mosquito populations. Thus, the plant derived products have received increased attention from scientists and nowadays more than 2,000 plant species have already been screened as potent insecticides providing possible lead candidates to replace synthetic chemical insecticides for controlling mosquito larvae [13][14][15][16][17][18][19][20][21][22][23]. In this regard, plant extracts of the Lamiaceae family present an intriguing case, since they comprise a significant source of potential mosquito control agents [12,21].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

Michaelakis

Theotokatos²,

Koliopoulos

et al. 2007

Molecules

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Abstract:The chemical composition of the essential oils of the wild growing plants of Greek S. spinosa L., S. parnassica subsp. parnassica Heldr.& Sart ex Boiss., S. thymbra and S. montana were determined by GC and GC/MS analysis. The larvicidal activities of the essential oils were assayed against Culex pipiens biotype molestus. The analytical data indicated that various monoterpene hydrocarbons and phenolic monoterpenes constitute the major constituents of the oils, but their concentration varied greatly among the oils examined. The bioassay results indicated that the oils possess significant larvicidal activities and represent an inexpensive source of natural substances mixture that exhibit potentials for use to control the mosquito larvae.

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Two New Lactones with Mosquito Larvicidal Activity from Three Hortonia Species

Cited by 43 publications

References 7 publications

Effects of α,β-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti

Effects of α,β-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti

Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens

Essential Oils of Satureja Species: Insecticidal Effect on Culex pipiens Larvae (Diptera: Culicidae)

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