Two New Phenylpropanoid Derivatives from <i>Codonopsis tangshen</i><scp>Oliv</scp>.

Song, Dan; Chou, Gui‐Xin; Zhong, Guoyue; Wang, Zhengtao

doi:10.1002/hlca.200890213

Cited by 19 publications

(8 citation statements)

References 7 publications

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“…The phenylpropanoids tangshenosides I ( 21 ), II ( 22 ), III ( 23 ) and IV ( 24 ) were first isolated from C. tangshen [ 23 , 25 ]. Tangshenoside V ( 25 ), tangshenoside VI ( 26 ) and codonosides A ( 27 ) and B ( 28 ), considered to be the characteristic components, were isolated from C. tangshen [ 13 , 26 ]. Tangshenoside VI ( 26 ) was also isolated from the aerial parts of C. nervosa [ 27 ].…”

Section: Phenylpropanoidsmentioning

confidence: 99%

The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control

et al. 2014

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Codonopsis, in the family Campanulaceae, is a genus containing 42 species of dicotyledonous herbaceous perennial plants, predominantly found in Central, East and South Asia. Several Codonopsis species are widely used in traditional medicine and are considered to have multiple medicinal properties. Among the Codonopsis species, Codonopsis pilosula (Franch.) Nannf. and C. lanceolata (Sieb. et Zucc.) Benth. & Hook. f. ex Trautv. are more popular than others according to the findings, especially phytochemical and bioactive studies. Phytochemical research shows that Codonopsis species contain mainly polyacetylenes, phenylpropanoids, alkaloids, triterpenoids and polysaccharides, which contribute to multiple bioactivities. However, the mechanisms of their bioactivities need to be further elucidated. The less popular Codonopsis species remain to be studied and exploited. In addition, although a series of methods for the quality evaluation of Codonopsis species have been developed, a feasible and reliable approach to the efficacious and safe use of various Codonopsis species is still needed, with considering botanical origin, chemical constituents and bioactive effects. This review aims to provide up-to-date and comprehensive information on the phytochemistry, bioactivity and quality control of medicinal plants in the genus Codonopsis and to highlight current gaps in knowledge, which is useful for the wider development of the Codonopsis genus.

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Section: Phenylpropanoidsmentioning

confidence: 99%

The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control

et al. 2014

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“…The other components were tentatively identified according to their MS fragmentation pattern, and also by studying their UV spectral characteristics and reported literatures. Accordingly, the peaks were ascribed to cytidine (1) [27,28], uracil (2) [29,30], guanosine (4) [31,32], adenine nucleoside (6) [17,18], syringoside (7) [33,34] (10) [35], isomucronulatol-7,2′-di-O-glucoside (11) [36], biochanin-7-glucoside (12) [37,38], 9,10-dimethoxypterocarpan-3-O-xylosylglucoside (15) [39], 9,10-dimethoxypterocarpan-3-O-β-D-glucoside (16) [39], isomucronulatol-7-O-glucoside (17) [36,40], astragaloside VI (1′) [26,39,41], astragaloside VII (2′) [26,39,41], and astragaloside II (4′) [39,[41][42][43]. However, they still need to be further confirmed with the reference compounds and structural analysis by nuclear magnetic resonance (NMR) method.…”

Section: Identification Of Constituents In Sfi In Fingerprint Chromatmentioning

confidence: 99%

Chromatographic Fingerprint Analysis and Characterization of Constituents in Shenqi Fuzheng Injection by HPLC-DAD-ELSD and UFLC-DAD-Q-TOF Tandem Mass Spectrometry Techniques

Wang

Liu

Tong

et al. 2015

Acta Chromatographica

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Summary. Shenqi Fuzheng Injection (SFI) is a traditional Chinese medicine injection, widely used to enhance immune function of clinical cancer patients undergoing chemotherapy. In this study, a high-performance liquid chromatography-diode array detection-evaporative light scattering detection (HPLC-DAD-ELSD) method was established for quality control of SFI, which could simultaneously semiquantitatively reflect the constituents displayed in the chromatographic profile of SFI. The relative retention time and relative peak areas of the 21 common peaks related to the reference peak were calculated. The validity and advantage of this method were validated by systematically comparing chromatograms of 10 batches of SFI samples with the analytical methods of principal component analysis and angle cosine method recommended by the State Food and Drug Administration of China. Moreover, a total of 21 constituents of SFI were identified or tentatively characterized in the fingerprint via ultrafast liquid chromatography-diode array detection-quadrupole time-of-flight (UFLC-DAD-Q-TOF) tandem mass spectrometry technique on the basis of the retention time, ultraviolet spectra, fragmentation patterns, and reported literatures. All the results proved that the technique was useful in comprehensive quality evaluation of SFI and further study.

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“…in Chinese Pharmacopoeia (Chinese Pharmacopoeia Commission, ). The roots of C. pilosula and C. tangshen as well as Codonopsis Radix have been reported to contain polysaccharides, polyacetylenes, phenylpropanoids, alkaloids and triterpenoids (Wang and Wang, ; Zhu et al ., ; He et al ., ; Song et al ., ; Tsai and Lin, ; Wakana et al ., ). Pharmacological studies have shown that: polyacetylene lobetyolin played a protective role in gastric mucosa injury (Song et al ., ); total saponins from Codonopsis Radix have a protective effect on ischaemia‐reperfusion injury in rats after kidney transplantation (He et al ., ); total alkaloids from Codonopsis Radix caused a significant enhancement of nerve growth factor‐induced neurite outgrowth in PC12 cells as well as an increase of the phosphorylation of mitogen‐activated protein kinase (MAPK) (Liu et al ., ).…”

Section: Introductionmentioning

confidence: 99%

HPLC/UV Analysis of Polyacetylenes, Phenylpropanoid and Pyrrolidine Alkaloids in Medicinally UsedCodonopsisSpecies

Zhu

Komatsu

2014

Phytochem. Anal.

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Two New Phenylpropanoid Derivatives from Codonopsis tangshenOliv.

Cited by 19 publications

References 7 publications

The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control

The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control

Chromatographic Fingerprint Analysis and Characterization of Constituents in Shenqi Fuzheng Injection by HPLC-DAD-ELSD and UFLC-DAD-Q-TOF Tandem Mass Spectrometry Techniques

HPLC/UV Analysis of Polyacetylenes, Phenylpropanoid and Pyrrolidine Alkaloids in Medicinally UsedCodonopsisSpecies

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