Two New Polyacetylenes fromArtemisia eriopoda

Abstract

The aerial parts of Artemisia eriopoda (Compositae) afforded two new C (17)-polyacetylenes. Based on their IR, UV, EIMS, (1)H- and (13)C-NMR (DEPT) spectral data, the structures were elucidated to be (1,8 E,13 Z,16)-heptadecatetraene-4,6-diyne-3,11,12-triol and (1,8 E,12 E,14 Z)-heptadecatetraene-4,6-diyne-3,11-diol.

Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway

“…Artemisia eriopoda has been used as a folk medicine to treat rheumatoid arthritis, edema, and thanatophidia. 3 However, neither the sesquiterpenoid dimers nor the antihepatoma activity has been reported from A. eriopoda . Continuing research of the genus Artemisia revealed that the ethanol extract of A. eriopoda demonstrated cytotoxicity against HepG2, Huh7 and SK-Hep-1 cells (Supplementary Table 1 ).…”

Artemeriopolides A–D, two types of sesquiterpenoid dimers with rare carbon skeletons from Artemisia eriopoda and their antihepatoma cytotoxicity

“…During a continuing pursuit of complex and bioactive SDs from Artemisia species, [9][10][11][12][13] artemeriopolides A-D (1-4), four novel sesquiterpenoid dimers belonging to two carbon skeleton types, were isolated and characterized from A. eriopoda, which has been considered as an alternative traditional Chinese herb to A. annua in southern China and used to treat rheumatoid arthritis, edema, and thanatophidia in folk medicine. 16,17 To the best of our knowledge, artemeriopolides A (1) and B (2) feature a novel 5/6/7/5/6/6 hexacyclic scaffold composed of a 5(4→3)-abeo-12-nor-cadinane and a normal cadinane linked by a rare 2-oxaspiro [4.6]undecan-1,7-dione ring system. Artemeriopolides C (3) and D (4) with 6/6/5/6/5(6)/6/6 heptacyclic scaffolds were the first examples of sesquiterpenoid dimers, incorporating two normal cadinane sesquiterpenoid monomers and featuring a rare fused 2-oxaspiro [4.5]decan-1-one in 3 and 2-oxaspiro [5.5]undecan-1one in 4.…”

Chemical Composition and Insecticidal Activity of the Essential Oil of Artemisia eriopoda against Maize Weevil, Sitophilus zeamais

“…eriopoda is an herbaceous plant distributed mainly in the north of China and it was used as a substitute for the traditional medicinal herb (Folium Artemisiae Annuae) in some area of China. Previous phytochemical analysis had found polyacetylenes and eudesmane sesquiterpenes from the aerial parts of A. eriopoda [6][7][8][9]. However, the chemical composition of A. eriopoda essential oil has not been reported.…”