Two new polyhydroxysterols produced byFusarium solani, an endophytic fungus fromChloranthus multistachys

Abstract

A highly antagonistic endophytic fungus, designated strain CL39, was originated from the leaves of Chloranthus multistachys collected in Wulong of Chongqing municipality of China in November 2015. The strain was identified as Fusarium solani based on morphological characteristics, 5.8S gene and internal transcribed spacer sequence analysis. Two new compounds, 2β, 9α-dihydroxy-5α-methoxyergosta-7, 22-diene (1), 2β, 6β-dihydroxy-5α-methoxyergosta-7, 22-diene (2) have been isolated from the culture broth of the strain. Structures of the new compounds were elucidated by detailed analysis of their spectroscopic data aided by the comparison with reported data of related derivatives, and found to belong to the polyhydroxylated steroids with a hydroxyl at C-2 instead of C-3, a rare structure among the steroids. The extract of this strain and all isolated compounds were evaluated for their antagonistic activities.

Ability of endophytic fungi associated with Withania somnifera L. to control Fusarium Crown and Root Rot and to promote growth in tomato

“…isolated from the Taxus baccata bark was able to produce an antifungal metabolite identified as hydrocarbon which strongly inhibited F. oxysporum, Aspergillus niger, and Rhizopus stolonifera [61]. Additionally, two polyhydroxysterols were produced by F. solani, an endophytic fungus from Chloranthus multistachys which significantly reduced the mycelial growth of Penicillium digitatum, Alternaria brassicae, and Botrytis cinerea [62].…”

Two New Prenylated Glycine Derivatives from the Marine‐Derived Fungus Fusarium sp. TW56‐10

“…The genus, Fusarium , one of the most bioactive compound producers, was first described and defined as endophytic fungus on Malamaceae plants, and more than 1000 species have been found in plants and marine sediments by now [3,4] . Large number of researches have proved that Fusarium owned potential ability to produce diverse secondary metabolites like polyketides, [5–7] alkaloids, [8–10] terpenoids, [11–14] peptides, [15,16] and steroids, [17,18] a majority of which possessed multiple bioactivity, such as cytotoxic, [13,17] antifungal, [15,17] anti‐inflammatory, [14] antiproliferative [16] and so on.…”