Two New Quinochalcone Yellow Pigments from Carthamus tinctorius and Ca2+ Antagonistic Activity of Tinctormine.

Meselhy, Meselhy R.; Kadota, Shigetoshi; Momose, Yasunori; Hatakeyama, Noboru; Kusai, Akihiko; Hattori, Masao; Namba, Tsuneo

doi:10.1248/cpb.41.1796

Cited by 88 publications

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“…Hydroxysafflor yellow A (HSYA) is one of the major compounds isolated from C. tinctorius L. [19,20]. It has been reported that HSYA antagonizes platelet-activating factor receptor binding, inhibits platelet aggregation, and reduces thrombosis [21,22].…”

Section: Introductionmentioning

confidence: 99%

Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway

Chen¹,

Chen

Pang

et al. 2016

J Vasc Res

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Background: The flowers of Carthamus tinctorius L. are widely used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of C. tinctorius L. flowers, is known for its multiple biological activities. The present study investigated the effects of HSYA on angiogenesis in vitro and in a mouse hindlimb ischemia model. Methods: Using human umbilical vein endothelial cells (HUVEC) in vitro and a mouse hindlimb ischemia model in vivo, the angiogenic role of HSYA was evaluated. Results: HSYA significantly increased the capillary-like tube formation and migration of HUVEC. HSYA not only induced a rise in the expression of angiopoietin 1 and Tie-2 but it also increased phosphorylation of Tie-2, Akt, and extracellular signal-regulated kinase 1/2. Furthermore, an anti-Tie-2 neutralizing antibody significantly inhibited HSYA-induced HUVEC tube formation and migration. In vivo, the recovery of perfusion of ischemic hindlimb tissue after femoral artery interruption was significantly increased in HSYA-treated mice compared to vehicle controls. Consistent with these results, the arteriole and capillary densities in ischemic gastrocnemius muscles were significantly increased in HSYA-treated mice. Conclusions: These results indicate the potential utility of HSYA for the treatment of ischemic diseases.

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Section: Introductionmentioning

confidence: 99%

Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway

Chen¹,

Chen

Pang

et al. 2016

J Vasc Res

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“…SY is a natural yellow pigment and mixtures of water-soluble chalcone component, in which hydroxysafflor yellow A, safflower yellow A and safflower yellow B are the main components (Meselhy et al 1993;Takahashi et al 1982). All of these compounds have been classified within the quino chalcone family of flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Safflower yellow ameliorates cognition deficits and reduces tau phosphorylation in APP/PS1 transgenic mice

et al. 2016

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Alzheimer's disease (AD), the most common cause of dementia worldwide, is mainly characterized by the aggregated β-amyloid (Aβ) and hyperphosphorylated tau. Safflower yellow (SY) is a novel water extract of natural safflower and has been suggested to ameliorate memory deficits in several animal models of dementia. In this study, we aimed to investigate the effect and mechanism of SY on deficits of learning and memory and hyperphosphorylation of tau in APP/PS1 double transgenic mice. APP/PS1 mice were administered with SY (10, 30, 100 mg/kg) by oral gavage for three months at the age of six months. The ability of learning and memory was investigated using the step-down test and Morris water maze test, and protein level in the brain was evaluated using western blot. Here, we found that SY treatment can improve spatial learning and memory ability, and reduce tau hyperphosphorylation at Ser199, Thr205, Ser396, Ser404 sites in APP/PS1 mice. In addition, the activity the of cyclin-dependent kinase 5 (CDK-5) and glycogen synthase kinase 3β (GSK-3β), major kinases involved in tau phosphorylation, was siginificantly decreased in APP/PS1 mice by SY treatment. These results support SY can serve as a promising multitarget neuronal therapeutic agent for the treatment of AD.

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“…In our opinion, the flavonoids are of interest with respect to the manifestation of antioxidant and hepatoprotective activity by C. tinctorius flowers. According to the literature [4][5][6][7], flowers of this plant contain acacetin, luteolin, quercetin,…”

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confidence: 99%

Flavonoids of Carthamus tinctorius Flowers

Куркин

Kharisova

2014

Chem Nat Compd

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Two New Quinochalcone Yellow Pigments from Carthamus tinctorius and Ca2+ Antagonistic Activity of Tinctormine.

Cited by 88 publications

References 0 publications

Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway

Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway

Safflower yellow ameliorates cognition deficits and reduces tau phosphorylation in APP/PS1 transgenic mice

Flavonoids of Carthamus tinctorius Flowers

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