Two New Ring <i>A</i>‐Cleaved Lanostane‐Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus <i>Glomerella</i> sp. F00244

Guo, Kaizhong; Fang, Huiqin; Gui, Fu; Wang, Yuezhou; Xu, Qinyan; Deng, Xianming

doi:10.1002/hlca.201600039

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…The isolated compounds were subjected to antimicrobial evaluation with regards to the previous proved activities of Clitocybe species against various microorganisms [10,28]. The antibacterial activity of compounds 1-3 was investigated by agar disc diffusion method ( Table 1) Earlier studies demonstrated that cerevisterol (1) inhibited the growth of bacteria other than tested here (MIC value 25 µg/mL against S. typhi, S. aureus and A. niger, and MIC 50 μg/mL against E. faecalis) [29], while it was inactive against Bacillus subtilis, B. pumilus, S. aureus, M. luteus, C. albicans and A. niger at 20 µg/mL tested by disk diffusion method [30]. Similarly indol 3-carboxylic acid (3) was tested previously against a series of pathogenic fungi (Fusarium avenaceum, F. graminearum, F. culmorum and Pyricularia oryzae) and bacteria (S. aureus, E. coli and B. subtilis) but no antifungal or antibacterial activity was observed [31].…”

Section: Resultsmentioning

confidence: 99%

Isolation and characterization of chemical constituents from the mushroom Clitocybe nebularis

Yazdani¹,

Béni²,

Dékány³

et al. 2020

JRP

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In the course of our mycochemical studies the extract of Clitocybe nebularis was investigated with the aim to identify its bioactive secondary metabolites. Multistep chromatographic purification of the MeOH extract of C. nebularis resulted in the isolation of two steroids and an organic acid from the CHCl3 and ethyl acetate soluble fractions. The structures of the compounds were determined by NMR and MS spectroscopy as 5α-ergosta-7,22-diene-3β,5,6β-triol (cerevisterol) (1), (22E,24S)-5α-ergosta-7,22-diene-3β,5,6β,9α-tetraol (2), and indole-3-carboxylic acid (3). The antimicrobial activity of the compounds was analyzed by agar disc diffusion method against human pathogen strains of Streptococcus agalactiae, Staphylococcus epidermidis, Moraxella catarrhalis, Haemophilus influenzae, and Proteus mirabilis. The susceptibility assay revealed that compounds 2 and 3 have weak antimicrobial activity against M. catarrhalis. The current study represents the first isolation of compounds 1-3 from C. nebularis.

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Section: Resultsmentioning

confidence: 99%

Isolation and characterization of chemical constituents from the mushroom Clitocybe nebularis

Yazdani¹,

Béni²,

Dékány³

et al. 2020

JRP

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“…The 24-homo-30-nor-cycloartane triterpenoid 154 (Figure 11) was isolated from the endophytic fungus Mycoleptodiscus indicus FT1137. Compound 154 showed no activity against the human ovarian cancer cell line A2780 at a concentration of 20 µg/mL [83]. Three Lanostane-type triterpenes-sclerodols A-B 144-145 (Figure 11) and lanosta-8,23dien-3β,25-diol 146 (Figure 11)-were obtained from Eucalyptus grandis cultures derived from the endophytic fungus Scleroderma UFSMSc1, and the antifungal activities of compounds 144-146 against Candida albicans and Candida parapsolosis were evaluated by the agar diffusion method.…”

Section: Triterpenoidsmentioning

confidence: 99%

“…The cytotoxic activity of compounds 148-149 against the human ovarian cancer cell line HeLa was tested using the MTT assay. Compound 148 showed weak cytotoxic activity at a concentration of 10 µM with 21% inhibition [83]. Nine highly oxygenated schitriterpenoids-kadhenrischinins A-H 150-157 (Figure 11) and 7β-schinalactone C 158 (Figure 11)-were isolated from Penicillium sp.…”

Section: Triterpenoidsmentioning

confidence: 99%

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

Wen

Okyere

Wang

et al. 2022

JoF

111

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Plant-associated fungi (endophytic fungi) are a biodiversity-rich group of microorganisms that are normally found asymptomatically within plant tissues or in the intercellular spaces. Endophytic fungi promote the growth of host plants by directly producing secondary metabolites, which enhances the plant’s resistance to biotic and abiotic stresses. Additionally, they are capable of biosynthesizing medically important “phytochemicals” that were initially thought to be produced only by the host plant. In this review, we summarized some compounds from endophyte fungi with novel structures and diverse biological activities published between 2011 and 2021, with a focus on the origin of endophytic fungi, the structural and biological activity of the compounds they produce, and special attention paid to the exploration of pharmacological activities and mechanisms of action of certain compounds. This review revealed that endophytic fungi had high potential to be harnessed as an alternative source of secondary metabolites for pharmacological studies.

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“…Similar results with respect to antimicrobial activity of 60 were obtained by Zhou et al [ 213 ]. On the other hand, no antimicrobial activity for cerevisterol ( 60 ) was reported in works [ 214 , 215 ].…”

Section: Polyolsmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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Two New Ring A‐Cleaved Lanostane‐Type Triterpenoids and Four Known Steroids Isolated from Endophytic Fungus Glomerella sp. F00244

Cited by 9 publications

References 20 publications

Isolation and characterization of chemical constituents from the mushroom Clitocybe nebularis

Isolation and characterization of chemical constituents from the mushroom Clitocybe nebularis

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

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