Two new sesquiterpenes derivatives from marine fungus Leptosphaerulina Chartarum sp. 3608

Abstract

Two new sesquiterpenes, leptoterpenes A (1) and B (2) were isolated from the fungus Leptosphaerulina Chartarum sp. 3608, derived from a crinoid. It's the first chemical study on this species. The structures of these compounds were elucidated by spectroscopic methods including NMR and MS spectrometry. The absolute configurations of the new compounds were determined on the basis of the single-crystal X-ray diffraction and electronic circular dichroism data analysis. All compounds were tested for their antiinflammatory activity and the inhibitory effects on Tyrosyl DNA phosphodiesterase II (TDP2).

Characterization of Nuclear and Mitochondrial Genomes of Two Tobacco Endophytic Fungi Leptosphaerulina chartarum and Curvularia trifolii and Their Contributions to Phylogenetic Implications in the Pleosporales

“…In the process of agelong coevolution with host plants, endophytic fungi could produce various secondary metabolites with kinds of biological activities to assist tobacco in resisting biotic or abiotic stress, promote tobacco growth, and improve their bacteriostatic activities [28]. With the rapid development of modern analytical chemistry and bioinformatics, increasing secondary metabolites from C. trifolii and L. chartarum with excellent activities were exploited [29,30]. Currently, two endophityc fungi C. trifolii and L. chartarum were isolated from tobacco.…”

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

“…Three relatively rare nitrobenzoyl sesquiterpenoids in nature, including two new compounds insulicolide B (32) and insulicolide C (34), and one novel natural product, 14-O-acetylinsulicolide A (33), were isolated from Aspergillus ochraceus Jcma1F17, which is related to the marine alga Coelarthrum sp. [23].…”

“…An investigation of extracts from the crinoid-derived fungus Leptosphaerulina chartarum sp. 3608 afforded two new sesquiterpenes, leptoterpenes A (106) and B (107) [34].…”

Total Synthesis of Leptochartamides A and B: Two Enantiomeric Pairs of Hydroxybenzyl Dimers from a Deep-Sea Fungus Leptosphaerulina chartarum

“…The research on MNPs from deep-sea-derived fungi mainly focuses on the genus of Aspergillus and Penicillium. Although 66 species have been described for the genus Leptosphaerulina, the previous reports in the chemical literature from the species Leptosphaerulina chartarum isolating from a crinoid only detailed the new isolation of two sesquiterpenes, two benzothiazinones, and five naphthalenones . As part of our ongoing research on discovering new metabolites from marine microorganisms, L.…”

“…20 The research on MNPs from deep-sea-derived fungi mainly focuses on the genus of Aspergillus and Penicillium. Although 66 species have been described for the genus Leptosphaerulina, 21 the previous reports in the chemical literature from the species Leptosphaerulina chartarum isolating from a crinoid only detailed the new isolation of two sesquiterpenes, 22 two benzothiazinones, 23 and five naphthalenones. 24 As part of our ongoing research on discovering new metabolites from marine microorganisms, L. chartarum MCCC 3A00935, a fungus isolated from the deep-sea (−5842 m) sediment layer of the Western Pacific Ocean, came into our sight, which led to the isolation of two pairs of enantiomers, leptochartamides A (1a and 1b, Figure 1) and B (2a and 2b, Figure 1).…”