Two new thymol derivatives from
            <i>Eupatorium fortunei</i>

From the aerial parts of Eupatorium fortunei, four thymol derivatives (1-4) were isolated and structurally elucidated by NMR and mass spectroscopic methods. Of which, a new thymol derivative (1) was characterized and its absolute configuration was established by electronic circular dichroism quantum method. In addition, the 1D and 2D NMR as well as HR-ESI mass spectral data of 2 were provided for the first time. Compounds 2-4 were evaluated for their inhibitory effects against α-glucosidase and acetylcholinesterase enzymatic activities. All tested compounds showed weak inhibition at the concentration range of 1-256 μg/mL in both enzymatic assays.

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Sesquiterpenoids and steroids from Eupatorium fortunei and their inhibitory effects on NO production

Miao,

Pan,

Wang

et al. 2024

Natural Product Research

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Seven sesquiterpenoids, including a clovane-phenylpropanoid hybrid (1), a clovane-menthane hybrid (2) and five linear ones incorporating a tetrahydrofuran ring (36 & 8), along with four steroids (7 & 911), were obtained from the ethanolic extract of a well-known aromatic and medicinal herb Eupatorium fortunei. Their structures were characterized by detailed analyses of spectroscopic data and comparison with known analogues, with seven (17) of them being described for the first time. Compounds 1 and 2 represent the first examples of clovane type sesquiterpenoids hybridizing with other class of natural products, and this is also the first record of linear sesquiterpenyl constituents (36 & 8) from the title species. All the isolates were evaluated for their inhibitory effect on NO production induced by LPS in murine RAW264.7 macrophage cells, and 1, 7, 10 and 11 exhibited moderate activity with IC50 values in the range of 24.443.5 M.

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Two new thymol derivatives from Eupatorium fortunei

Cited by 4 publications

References 17 publications

Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches

Chemical constituents from Eupatorium fortunei and their anti-inflammatory evaluation by in silico and experimental approaches

Characterization of thymol derivatives from Eupatorium fortunei Turcz. aerial parts

Sesquiterpenoids and steroids from Eupatorium fortunei and their inhibitory effects on NO production

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