Two phases of the contingent negative variation in humans: Association with motor and mental functions

Lukhanina, E. P.; Karaban, I. N.; Burenok, Yu. A.; Melnyk, N. A.; Berezetskaya, N. M.

doi:10.1007/s11055-006-0025-9

Cited by 10 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CNV amplitude increased after the start of the dopaminergic medication. This was replicated in other studies (Lukhanina et al , 2006). These results are, therefore, similar to the results for BP indicating dependence of the CNV generation on dopaminergic processes.…”

Section: Contingent Negative Variation In Pdsupporting

confidence: 89%

Movement-related potentials in Parkinson’s disease

Georgiev

Lange

Seer

et al. 2016

Clinical Neurophysiology

View full text Add to dashboard Cite

To date, many different approaches have been used to study the impairment of motor function in Parkinson's disease (PD). Event-related potentials (ERPs) are averaged amplitude fluctuations of the ongoing EEG activity that are time locked to specific sensory, motor or cognitive events, and as such can be used to study different brain processes with an excellent temporal resolution. Movement-related potentials (MRPs) are ERPs associated with processes of voluntary movement preparation and execution in different paradigms. In this review we concentrate on MRPs in PD. We review studies recording the Bereitschaftspotential, the Contingent Negative Variation, and the lateralized readiness potential in PD to highlight the contributions they have made to further understanding motor deficits in PD. Possible directions for future research are also discussed.

show abstract

Section: Contingent Negative Variation In Pdsupporting

confidence: 89%

Movement-related potentials in Parkinson’s disease

Georgiev

Lange

Seer

et al. 2016

Clinical Neurophysiology

View full text Add to dashboard Cite

show abstract

“…The level of activation of these structures is determined, to a considerable extent, by postural/tonic impulsation from receptors of the trunk muscles, including respiratory intercostal muscles [2][3][4][5]23]. The negative correlations between the CNV area and the level of postural disorders in PD (r = -0.36, P < 0.05), as well as the level of postural instability (r = -0.55, P < 0.001) found in our study, confirm the hypothesis proposed earlier [8] on the significant influence of the neuronal systems responsible for coordination of muscular interactions on generation of the CNV.…”

Section: Discussionsupporting

confidence: 89%

“…It was also found that there is a dependence between the parameters of endogenous motor potentials and the state of both the mechanisms of direct motor control and the mechanisms responsible for higher integral nerve processes, levels of attention and motivation, and voluntary efforts [8][9][10]. Information on the effects of the autonomic nervous system on motor EEG potentials remains rather limited.…”

Section: Introductionmentioning

confidence: 99%

Correlation between the parameters of contingent negative variation and characteristics of variational pulsometry in Parkinsonian patients

Lukhanina

Karaban²,

Melnyk³

et al. 2008

Neurophysiology

Self Cite

View full text Add to dashboard Cite

In patients suffering from Parkinson's disease (PD), we analyzed correlations between the parameters of contingent negative variation (CNV) and data of variational pulsometry (according to the measurements of R-R ECG intervals). Studies were carried out on 35 patients (group PD), 49 to 74 years old, with the stage of disease of 1.5 to 3.0 according to the Hoehn-Yahr international classification. In the course of CNV recording (i.e., in the state of a certain functional loading), we observed significant negative correlations between the integral magnitude (area) of this potential and indices of variational pulsometry (RMSSD, SDNN, C. var, and HF) that characterize the intensity of parasympathetic (respiratory) influences on the cardiovascular system. In the control group, such correlations were absent. We found significant correlations between the autonomic balance, CNV magnitude, and stage of PD reflecting the level of generalization of the pathological process. In the subgroup of patients with the PD stage 1.5 to 2.0, significant changes in the mean values of indices of parasympathetic influences during recording of the CNV were not observed, while in another subgroup (the PD stage 2.5 to 3.0), these values increased significantly (P < 0.05 and P < 0.01). If the estimates of the PD stage were low, the CNV area demonstrated greater values (P < 0.01). The disturbance of coordination of muscle-to-muscle interactions in the PD group is, probably, an important factor responsible for parasympathetic dysregulation and suppression of the CNV generation. We found positive correlation between the intensity of parasympathetic influences in the course of CNV recording and the level of postural disorders (r = 0.37, P < 0.05). On the contrary, the CNV magnitude demonstrated a negative correlation with the intensity of these disorders (r = -0.36, P < 0.05), as well as with the level of postural instability (r = -0.55, P < 0.001). We hypothesize that alterations of the autonomic balance and the activity of those cerebral structures, which are responsible for the motor readiness, result, to a significant extent, from weakening of the activity of the noradrenergic system due to degenerative processes developing in cells of the locus coeruleus. The impairment of the latter structure, together with degeneration of neurons of the substantia nigra and a decrease in the level of nigro-striatal dopamine, underlies the pathomorphological pattern of PD.

show abstract

“…The dependence between the parameters of the other endogenous potential, contingent negative variation (CNV), and the indices of HRV was also observed [23]. The parameters of CNV reflect the readiness of cerebral neuronal structures to control the corresponding actions and are directly related to the processes of orientation, memory, and attention [24,25].…”

Section: Discussionmentioning

confidence: 99%

Correlations between indices of P300 EEG potential, cognitive tests, and variational pulsometry in Parkinsonian patients

Lukhanina

Melnyk²,

Berezetskaya³

et al. 2008

Neurophysiology

Self Cite

View full text Add to dashboard Cite

The parameters of an event-related EEG potential (ERP), Р300 wave, are now extensively used as objective neurophysiological indices of the state of cognitive functions. At the same time, information on the effects of the autonomic nervous system on the parameters of Р300 is limited. In Parkinson's disease clinics, in addition to the leading motor disorders, more or less clear psychoemotional, cognitive, and autonomic (in particular cardiovascular) impairments are usually observed. This allows one to study the dependence between the cardiovascular dysfunction and intensity of cognitive disorders in Parkinsonian patients. In our study on this contingent, we analyzed correlations between the parameters of P300 potential, indices of the state of the cognitive sphere (determined using a questionnaire, Mini Mental State Examination, MMSE, and a Luriya's test), and indices of variational pulsometry. Thirty-five Parkinsonian patients (49 to 74 years, severity of disease 1.5 to 3.0 by the international classification) were examined. We found a negative influence of excessive sympathetic tonus in cardiovascular control on the state of cognitive functions. The latency of Р300 potential was longer in patients with greater intensities of sympathetic influences on the cardiovascular system. The coefficients of correlation of the latency of Р300 with the amplitude of mode of R-R intervals (AMo), index of tension in the regulatory systems by Baevskii (IT), and index of autonomic balance by Baevskii (IAB) were 0.52 (P < 0.01), 0.36 (P < 0.05), and 0.37 (P < 0.05), respectively. The above autonomic indices demonstrated significant negative correlations with the volume of short-term memory measured by Luriya's test. The Р300 latency, in turn, showed negative correlations with the memory volume estimated by the MMSE scale and Luriya's test. With increase in the age of patients, the degree of the above-mentioned correlations between the Р300 latency, memory volume (by Luriya's test), and parameters of variational pulsometry increased. Our data emphasize the expedience of "routine" studies of the balance of sympathetic and parasympathetic control in pathological states accompanied by clear or subclinical cognitive disorders. Early recognition of cardiovascular dysfunction and its corresponding therapeutic correction should improve the state of brain functions and quality of life in patients suffering from neurodegenerative diseases, in particular from Parkinson's disease.

show abstract

Two phases of the contingent negative variation in humans: Association with motor and mental functions

Cited by 10 publications

References 16 publications

Movement-related potentials in Parkinson’s disease

Movement-related potentials in Parkinson’s disease

Correlation between the parameters of contingent negative variation and characteristics of variational pulsometry in Parkinsonian patients

Correlations between indices of P300 EEG potential, cognitive tests, and variational pulsometry in Parkinsonian patients

Contact Info

Product

Resources

About