Two-photon absorption-induced drug delivery from polymers for medical applications

Kim, Hee Cheol; Kreiling, Stefan; Haertner, Sebastian; Hesse, Lutz; Greiner, Andreas; Hampp, Norbert

doi:10.1117/12.523588

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,109,110 For instance, two-photon absorption has proven useful in the context of solid-state optical data storage. 71 By focusing an intense laser beam (3 mJ over 10 ns) onto twophoton absorbing dyes, aggregation and de-aggregation of the excimer-forming cyano-oligophenylene vinylenes in poly-(ethylene terephthalate glycol) allowed us to alternate between ''on'' and ''off'' states.…”

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

“…The utilization of TTA-UC as a photochemical route still remains an oddity in comparison to several other UC methodologies, such as two-photon absorption or energy transfer upconversion, which have been vastly developed over the years for nanofabrication and other drug release methodologies. 6,109,110 For instance, two-photon absorption has proven useful in the context of solid-state optical data storage. 71 By focusing an intense laser beam (3 mJ over 10 ns) onto twophoton absorbing dyes, aggregation and de-aggregation of the excimer-forming cyano-oligophenylene vinylenes in poly-(ethylene terephthalate glycol) allowed us to alternate between ''on'' and ''off'' states.…”

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

“…Moreover, in biological systems where polymeric drug delivery systems (e.g. micelles) offer the possibility to optically trigger the release of the drug payload, 109,111 operating at lower power densities would minimize the damage elicited by high power lasers. In the following paragraphs, several attempts to perform photochemical reactions by means of TTA-UC are reviewed.…”

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

See 2 more Smart Citations

Low-power photon upconversion through triplet–triplet annihilation in polymers

2012

View full text Add to dashboard Cite

Low-power upconversion via sensitized triplet-triplet annihilation (TTA-UC) is a useful and versatile process that allows for the conversion of optical radiation into photons of higher energy. While this effect had been known to occur in solution for some 50 years, it was only very recently realized for the first time in polymers. The possibility to realize the TTA-UC process in solid materials is important for a variety of applications that range from the optimization of photovoltaic devices to bioimaging. This article provides a brief introduction to the field, summarizes the underlying photophysical aspects, reviews the design concepts for TTA-UC in polymers, and summarizes the recent advances in the development of such materials.

show abstract

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

Section: Photochemistry: Using Tta-uc To Induce Chemical Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

Low-power photon upconversion through triplet–triplet annihilation in polymers

2012

View full text Add to dashboard Cite

show abstract

“…In a mixture of 9-ml chloroform-acetone ͑1:2 v/v͒ 0.2-g PB-MAOC, 1.16-g ͑4.8-mmol͒ H5FU and 0.18-g ͑0.96-mmol͒ benzophenone were dissolved and irradiated in a Rayonettype photoreactor ͑12 Eversun L40W / 79K, Osram, Munich, Germany, concentrically installed͒ under continuous stirring for 20 h. Precipitating the crude product twice in methanol returned 0.18 g of the PBMAOCH5FU polymer ͑yield 91%͒. 74…”

Section: H5fu Loaded Polymer ͑Pbmaoch5fu͒mentioning

confidence: 99%

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

et al. 2006

Self Cite

View full text Add to dashboard Cite

Tens of millions of cataract surgeries are done every year and the number is increasing heavily. Posterior capsule opacification is the major postoperative complication with an incidence of 10 to 50% within 5 years, depending on the age of the patient. We present a novel approach for secondary cataract treatment in a noninvasive manner. Photochemically triggered drug release from a polymer enables repeated drug applications for cataract treatment years after implantation of the intraocular lens, just when needed. However, light in the visible spectral range must pass through the lens but must not induce drug release. We demonstrate that two-photon absorption photochemistry is a powerful tool to overcome this problem. With wavelengths in the visible regime, a photochemical reaction that requires energies in the UV is triggered. The high intensities needed for this process never occur in any lighting condition in daily lives, but may be easily obtained with focused laser beams routinely used in ophthalmology. The properties of the therapeutic system are specified and the function is demonstrated by in-vitro cell tests. Noninvasive multidose photochemically triggered drug release from implanted intraocular lenses carrying a drug depot may be a therapeutic as well as an economic choice to established treatments of secondary cataracts.

show abstract

Short Electrospun Fibers by UV Cutting Method

Stoiljkovic

Agarwal

2008

Macro Materials & Eng

View full text Add to dashboard Cite

Short electrospun fibers were obtained by using UV cutting method. Either polymers with double bonds with a photocross‐linker (CL) and photoinitiator (PI) or known photochemistry of coumarin ([2 + 2] cycloaddition reaction) without the addition of CL and PI is utilized for making short electrospun fibers. The electrospun fibers were irradiated by UV light in the presence of a mask with a defined width of slits. The uncovered parts of fibers were cross‐linked and therefore became insoluble. The non‐cross‐linked parts were removed by immersion of the fibers into an appropriate solvent. The length of obtained short fibers can be controlled by changing the width of the slits of the employed mask.magnified image

show abstract

Two-photon absorption-induced drug delivery from polymers for medical applications

Cited by 5 publications

References 0 publications

Low-power photon upconversion through triplet–triplet annihilation in polymers

Low-power photon upconversion through triplet–triplet annihilation in polymers

Two-photon absorption-controlled multidose drug release: a novel approach for secondary cataract treatment

Short Electrospun Fibers by UV Cutting Method

Contact Info

Product

Resources

About