In nanochannel flows, the thermal resistance at the fluid-solid interface may depend on the flow scenario. In this work, we study the interfacial thermal resistance R th in nanoscale force-driven flows at different temperatures and fluid-wall interactions. For Ar flows in Cu and Ag channels, the fluid-wall binding energy is strong and it is found that R th assumes a maximum value as the external force is varied. The maximum value is caused by the fluid adsorption on the solid surfaces and the temperature increase in the fluid due to viscous frictions. However, when the fluid-wall interaction is weak, the maximum value is not observed and the interfacial thermal resistance decreases monotonously with increasing external force. With the presence of fluid adsorption, it is also found that the peak in R th is more detectable at low temperature than high temperature. © 2010 American Institute of Physics. ͓doi:10.1063/1.3327931͔ Thermal management is a key issue in the design of electronic devices. Among the available techniques, the liquid-based cooling methods are quite promising in removing the heat in high-power devices. [1][2][3][4] In certain liquid-based cooling systems, liquid coolants are circulated through micro-or nanoscale channels, which are attached to the heat sources, such as chips. The cooling capacity of such methods depends on the flow rate and thermal resistance at the liquidsolid interface. The flow rate can be controlled by a pump and a high flow rate is usually desired to enhance the cooling capacity. The interfacial thermal resistance R th depends on many parameters, such as the fluid-wall interaction, surface structure, and temperature. 5-10 Our recently work indicates that R th is also associated with the flow rate and the effect of flow rate on the thermal resistance is coupled with the fluidwall interaction and temperature. 11 However, the detailed information about the dependence of R th on the flow rate is unavailable. The coupling of the flow rate, fluid-wall interaction, and R th could be nonlinear and may defy our intuitive understanding that high flow rate improves the cooling capacity. Therefore, it is necessary to explore the relationship between the flow rate and R th under various conditions. This is also important in the design and optimization of liquidbased cooling techniques.Compared with experiments, molecular dynamics ͑MD͒ simulations offer an easy way to investigate the effects of various parameters on the thermal resistance at the fluidsolid interface. 5-15 Most of the previous MD studies are mainly focused on how the surface wettability ͑or fluidsurface binding energy͒ and structure are related to R th . Little work has been carried out to understand the effect of flow rate on R th . In addition, how the thermal resistance is coupled with the flow rate may be affected by the fluid-surface interaction parameters and the fluid heating due to various sources of friction. 11 Although the relationship between the thermal and velocity slips has been numerically investigated, 7 ...