Two sets of monozygotic twins after intracytoplasmic sperm injection and transfer of two embryos on day 2

Carrillo-Vadillo, Raquel; García-Lozano, Juan Carlos; Arana, María Dolores Lozano; Rivera, Juan Luis Moliní; Martín, Pascual Sánchez; Antiñolo, Guillermo

doi:10.1016/j.fertnstert.2007.01.110

Cited by 20 publications

(18 citation statements)

References 21 publications

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“…The zona is considered to act as a barrier that limits the degree in which the inner cell mass can divide and disruption of this barrier may contribute to the twinning process [20]. Knopman et al state that the delayed implantation time seen for blastocyst transfer may contribute to the increased risk whereas Carrillo-Vadillo et al [21] and Franasiak et al [17] declare that the prolonged culture exposure may cause a decline in the integrity of the zona pellucida leading to an increased chance of the embryo dividing due to the herniation of the blastomeres. Milki et al [22] suggests from animal studies, that biochemical mechanism such as low calcium levels in the blastocyst before implantation could possibly lead to the weakening of the inner cell mass making splitting of the embryo more likely.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer

Z¹,

Shah²

2016

Human Genet Embryol

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To determine if prolonged time in embryo culture has an effect on the rate, sex ratio, and perinatal outcomes of monozygotic twins (MZT) following either cleavage stage or blastocyst embryo transfer after assisted conception. This is a retrospective study of 2,316 consecutive clinical pregnancies resulting from cleavage stage transfer (CT) and blastocyst transfer (BT). Criteria examined included (i) incidences (ii) sex ratios (iii) gestational age and birth weight; (iv) perinatal outcomes of these pregnancies from cleavage stage and blastocyst transfer procedures. Monozygotic twin pregnancies were identified by (i) presence of a gestational sac containing more than one fetal pole with cardiac activity, (ii) the number of gestational sacs or fetal hearts exceeds the number of embryos transferred and (iii) twin pregnancies following a single embryo transfer.Overall the incidence of twinning was 1.64% (38 out of 2,316 pregnancies). The frequency of twinning was 2.3 × higher following BT (18 out of 649) compared to CT (20 out of 1,667). IVF techniques skewed the sex ratio in favour of males while ICSI significantly favoured females. There was no statistically significant difference between transfer type and gestational age, birth weight and perinatal outcome. All pregnancies resulted in the birth of 86 infants. In our experience, BT more than doubles the chances of conceiving a monozygotic twin pregnancy, however IVF techniques lead to a greater likelihood of male birth(s) if twins are conceived. Appropriate pre-conception counselling should be given to advise the potential risks associated with both types of transfer as well as using alternative methods such as single embryo transfer to reduce the risk of multiple gestations.

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Section: Discussionmentioning

confidence: 99%

Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer

Z¹,

Shah²

2016

Human Genet Embryol

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“…The last report of two sets of MZG twins after ICSI was by Carrillo-Vadillo et al (16). After counseling, the couple decided to proceed to a nonselective reduction of a set of monozygotic twins.…”

Section: Discussionmentioning

confidence: 99%

“…After counseling, the couple decided to proceed to a nonselective reduction of a set of monozygotic twins. The remaining set of twins died at 13 th week of pregnancy (16).…”

Section: Discussionmentioning

confidence: 99%

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Successful pregnancy and delivery of two sets of monozygotic twins after intracytoplasmic sperm injection and embryo transfer: case report and literature review

Grgić

Ivanišević

Đelmiš

et al. 2009

Fertility and Sterility

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“…Numerous articles have reported a significantly higher incidence of MZT following assisted reproduction cycles than after natural conception [1,[3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Monozygotic twins with discordant karyotypes following preimplantation genetic screening and single embryo transfer: case report

Tauwinklova¹,

Gaillyová

Trávník³

et al. 2010

J Assist Reprod Genet

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Two sets of monozygotic twins after intracytoplasmic sperm injection and transfer of two embryos on day 2

Cited by 20 publications

References 21 publications

Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer

Incidence, Sex Ratio and Perinatal Outcomes of IVF and ICSI Monozygotic Twin Pregnancies Following either Cleavage or Blastocyst Stage Embryo Transfer

Successful pregnancy and delivery of two sets of monozygotic twins after intracytoplasmic sperm injection and embryo transfer: case report and literature review

Monozygotic twins with discordant karyotypes following preimplantation genetic screening and single embryo transfer: case report

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