Two Sources of the Russian Patrilineal Heritage in Their Eurasian Context

Balanovsky, Oleg; Rootsi, Siiri; Pshenichnov, Andrey; Kivisild, Toomas; Churnosov, Mikhail; Evseeva, Irina; Pocheshkhova, Elvira; Boldyreva, M N; Yankovsky, N. K.; Balanovska, Elena; Villems, Richard

doi:10.1016/j.ajhg.2007.09.019

Cited by 142 publications

(115 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Notably, genetic boundaries were determined to a greater extent by geographic rather than linguistic boundaries, ie, genetic boundaries between Hungary and its neighbors were not significant relative to continental geographic boundaries (Rosser et al, 2000). In separate studies, Poles and Ukrainians were found to share a common patrilineal heritage together with southwestern Russians (Balanovsky et al, 2008) while Poles and Germans were genetically separated according to the present political boundary (Kayser et al, 2005). Nevertheless, intraEuropean selection signatures on AVPR1B have not been studied and thus any correlation with patrilineal boundaries is speculative.…”

Section: Consortium 2010mentioning

confidence: 99%

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Ben-Efraim

Wasserman

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

The cortisol response to psychosocial stress may become dysregulated in stress-related disorders. It is potentiated by pituitary secretion of adrenocorticotropic hormone (ACTH), which is, in part, regulated by arginine vasopressin receptor-1B (AVPR1B). AVPR1B variants were previously reported to associate with mood and anxiety disorders. This study aims, for the first time, to investigate association of AVPR1B genetic variants with mood and anxiety outcomes in suicidal behavior.Using a family-based study design of 660 complete nuclear family trios with offspring who have made a suicide attempt (SA), we tested the direct association and linkage of AVPR1B single nucleotide polymorphisms (SNPs) with SA, as well as with depression and anxiety in SA. Main findings were the association and linkage of AVPR1B exon 1 SNP rs33990840 and a major 6-SNP haplotype representative of all common AVPR1B-SNPs, on the outcome of high Beck Depression Inventory scores in SA. By contrast, genetic associations with lifetime diagnoses of depression and anxiety in SA or gene-environment interactions between AVPR1B variants and stressful life events (SLEs) were not significant. An exploratory screen of interactions between AVPR1B and CRHR1 (corticotropin-releasing hormone receptor-1), the principal pituitary regulator of ACTH secretion, showed no support for gene-gene interactions on the studied outcomes. The results suggest that AVPR1B genetic variation, eg, non-synonymous SNP rs33990840 mediating putative consequences on ligand binding, has a role in SA etiology characterized by elevated depression symptoms, without involving AVPR1B-moderation of SLEs.

show abstract

Section: Consortium 2010mentioning

confidence: 99%

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Ben-Efraim

Wasserman

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…This is reflected in the haplogroup distribution: the Scandinavian haplogroup I occurs with frequencies 430% only in western Finland. 4 Haplogroup N3, typical for Fenno-Ugric populations of north-eastern Europe, 48,50 is observed in all parts of Finland but reaches high frequencies (B79%) only in eastern Finland. The interregional dichotomy results in large F ST estimates between eastern and western Finland and, consequently, in the clustering of populations (Figures 3 and 4).…”

Section: Gene Flow From Scandinaviamentioning

confidence: 99%

Genetic markers and population history: Finland revisited

et al. 2009

View full text Add to dashboard Cite

The Finnish population in Northern Europe has been a target of extensive genetic studies during the last decades. The population is considered as a homogeneous isolate, well suited for gene mapping studies because of its reduced diversity and homogeneity. However, several studies have shown substantial differences between the eastern and western parts of the country, especially in the male-mediated Y chromosome. This divergence is evident in non-neutral genetic variation also and it is usually explained to stem from founder effects occurring in the settlement of eastern Finland as late as in the 16th century. Here, we have reassessed this population historical scenario using Y-chromosomal, mitochondrial and autosomal markers and geographical sampling covering entire Finland. The obtained results suggest substantial Scandinavian gene flow into south-western, but not into the eastern, Finland. Male-biased Scandinavian gene flow into the south-western parts of the country would plausibly explain the large interregional differences observed in the Y-chromosome, and the relative homogeneity in the mitochondrial and autosomal data. On the basis of these results, we suggest that the expression of 'Finnish Disease Heritage' illnesses, more common in the eastern/north-eastern Finland, stems from long-term drift, rather than from relatively recent founder effects.

show abstract

“…R1a was identified in excavated DNA in Germany with the dating of 4600 ybp (Haak et al, 2008), in Siberia, with the dating of 3800 -3400 ybp (Keyser et al, 2009), in Tarim Basin, Xinjiang, China, with the dating of ~4000 ybp (Li et al, 2010). Its distribution was described in various parts of Eurasia (e.g., Wells et al, 2001;Behar et al, 2003;Cinnioglu et al, 2004;Kharkov et al, 2004;Sengupta et al, 2006;Balanovsky et al, 2008;Sharma et al, 2009;Underhill et al, 2009;Abu-Amero et al, 2009). However, only in the last few years, thank mainly to efforts of Dr. Peter Underhill's laboratory at Stanford University, Dr. Thomas Krahn of Family Tree DNA's Genomics Research Center, and researchers of 1000 Genomes Project, many new SNPs in haplogroup R1a have been discovered; as indicated by beginning letters M, L, and Z, respectively, in the SNPs below.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, most of descendants of the ancient peoples who carry European R1a live in Eastern Europe, primarily in Russia (up to 63% of the population) and Poland, Ukraine, Belarus (up to 57% of the population in the last three countries) Balanovsky et al, 2008;Kayser et al, 2005;Kharkov et al, 2004Kharkov et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%

Haplogroup R1a, Its Subclades and Branches in Europe During the Last 9,000 Years

Rozhanskii¹,

Klyosov²

2012

View full text Add to dashboard Cite

This study identifies and describes 38 branches of the haplogroup R1a STR haplotypes which currently exist in Europe or which migrated from Europe to areas in the east, south, and southeast between 6000 and 4500 years before the present (ybp). The study is based on 2471 haplotypes which have been tested for either 67-or 111-markers; it essentially creates a unified robust system, which assembles dozens of R1a-SNPs and thousands of STRs and assigned haplotypes to branches, some of which do not have SNP assignments as yet. The assembled system consists of base (deduced ancestral) haplotypes, one for each STR branch and for each SNP-assigned subclade, each with its characteristic (ancestral) set of alleles, arranged in the chronological space from ~9000 ybp to 1300 ybp. We found that the most ancient R1a subclades (R1a1-M198− and R1a1a-M198+/M417−) bearers of which currently live in Europe (the present day haplotypes are scattered between England and the Balkans) appeared in Europe at least 7300 ybp, and possibly 9000 ybp. R1a's three principal downstream subclades, L664 (North-Western branch), Z93 (South-Eastern branch), and Z283 (Eurasian branch), split from their common European ancestor at about the same time, around 7000 -6000 ybp. L664 apparently stayed in North-Western Europe; its lineage recovered and began expanding ~4575 ybp. The Z93 subclade began to expand during the Aryan migrations, on the Aryan's journey to India and the Middle East in the 3rd-2nd millennia BC. The Z283 subclade split ~5500 ybp into three branches. One of them, Z280 (the Central Eurasian branch) moved east to the Russian Plain in 4800 -4600 ybp, and formed at least 16 sub-branches there and in the course of the later westward repopulation of Europe in the 1st millennium BC-1st millennium CE. Some of the older branches, like the Russian Plain branch, largely stayed in the present Russia-Ukraine-Belarus-PolandBaltic countries region, and were described by early historians as the Scythians, Antes, Veneti, and a multitude of different proto-Slavic tribes (though many of them belonged to haplogroups other than R1a, primarily I1 and I2). Those R1a branches which are "older" than 3000 years, such as the Russian Plain branch (4600 ybp), the Western Eurasian (4300 ybp), and the Balto-Carpathian (4300 ybp), did not move en mass to Europe but stayed behind at the Russian Plain. In the middle of 1st millennium CE, the time of the collapse of the Roman Empire, multiple migrations of R1a were taking place eastward and westward; these migrations gradually formed the current landscape of R1a in Europe. All 38 branches and their datings are listed in the Appendix of this paper; current distribution maps are shown in the body of the paper.

show abstract

Two Sources of the Russian Patrilineal Heritage in Their Eurasian Context

Cited by 142 publications

References 53 publications

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Family-Based Study of AVPR1B Association and Interaction with Stressful Life Events on Depression and Anxiety in Suicide Attempts

Genetic markers and population history: Finland revisited

Haplogroup R1a, Its Subclades and Branches in Europe During the Last 9,000 Years

Contact Info

Product

Resources

About