Two-step synthesis of high aspect ratio gold nanorods

Mortier, Tom; Persoons, André; Verbiest, Thierry

doi:10.1007/s11532-005-0012-y

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Effective formation of nanorods by increasing pH was due to the increased formation of ascorbate ions, which possess greater reducibility in the presence of CTAB [15,28,33]. A simpler two-step approach for the formation of nanorods of aspect ratios >20 was demonstrated in another study [35]. The two-step procedure was economic compared to previously reported multi-step approaches.…”

Section: Seed-mediated Methodsmentioning

confidence: 98%

“…The two-step procedure was economic compared to previously reported multi-step approaches. Furthermore, the effect of concentration of stabilizing surfactant (CTAB) on nanorod size and aspect ratio was studied by this group [35]. A few other stabilizing surfactants utilized for AuNR preparation were hexadecyltrimethylammonium bromide (HTAB) and ooctadecyltrimethylammonium bromide (OTAB) (figure 10).…”

Section: Seed-mediated Methodsmentioning

confidence: 99%

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An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

Lakhani

Rompicharla²,

Ghosh³

et al. 2015

Nanotechnology

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Photothermal therapy, also referred to as optical hyperthermia or photothermal ablation, is an emerging strategy for treating solid tumours. Colloidal gold converts the absorbed light into localized heat via a non-radiative mechanism, surface plasmon resonance, which ablates the solid tumours. Several plasmon resonating nanostructures, including gold nanoparticles (AuNPs), gold nanorods (AuNRs), gold nanoshells, gold nanocages, copper sulphide and carbon nanotubes, have shown potential for photo-activated cancer therapy. Generally, spherical AuNPs display absorption maxima between 500-550 nm, making them inefficient due to low tissue penetration. On the other hand, AuNRs absorb light in the near-infrared (NIR) region that penetrates deeper with higher spatial precision, and causes no damage to the surrounding healthy tissues due to the low energy absorption of NIR light by normal tissue. Moreover, the absorption range of light can be fine-tuned to the NIR region by adjusting the aspect ratios of AuNRs. However, large-scale synthesis and stability of this colloidal system still poses challenges for clinical translation. In this review, we discuss various strategies applied up to now for the synthesis of AuNRs. Current trends in the pre-clinical development of multifunctional AuNRs with emphasis on preparation and application strategies in cancer therapy have been delineated.

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Section: Seed-mediated Methodsmentioning

confidence: 98%

Section: Seed-mediated Methodsmentioning

confidence: 99%

An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

Lakhani

Rompicharla²,

Ghosh³

et al. 2015

Nanotechnology

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show abstract

“…This citrate layer can easily be displaced by other capping agents that interact more strongly with the gold surface. Traditional capping agents for colloidal GNPs are molecules such as polymers [46], surfactants [47], dendrimers [48] and even peptides [49]. In our approach, mercapto alkanes were used.…”

Section: Citrate Versus Mercapto Alkanesmentioning

confidence: 99%

Increased stability of mercapto alkane functionalized Au nanoparticles towards DNA sensing

et al. 2010

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The use of gold nanoparticles (GNPs) in bioassays is often hampered by their colloidal stability. In this study, gold nanoparticles coated with different mercapto alkanes were investigated towards their stability. Hereto, the effects of the alkane chain length (5-11 methylene groups), the type of functional end-group (-OH or -COOH) and the amount of incorporated poly-ethylene oxide units (none, 3 or 6) on the GNP stabilization was evaluated. Based on these results, an optimal mercapto alkane (HS(CH(2))(11)PEO(6)COOH) was selected to increase the colloidal stability up to 2 M NaCl. Furthermore, it was proved that this mercapto alkane is ideally suited to enhance the stability of DNA functionalized GNPs in high electrolytic hybridization buffers. The effectiveness of these DNA functionalized GNPs was demonstrated in a sandwich assay using a surface plasmon resonance biosensor. The superior stability of these nanoparticles during hybridization may lead to enhanced biosensor technologies.

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Seedless synthesis of gold nanorods employing isopropyl radicals generated using gamma radiolysis technique

Biswal

Ramnani

Shirolikar

et al. 2010

IJNT

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Two-step synthesis of high aspect ratio gold nanorods

Cited by 3 publications

References 22 publications

An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

An overview of synthetic strategies and current applications of gold nanorods in cancer treatment

Increased stability of mercapto alkane functionalized Au nanoparticles towards DNA sensing

Seedless synthesis of gold nanorods employing isopropyl radicals generated using gamma radiolysis technique

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