Two unrelated episodes of Bacillus cereus bacteremia in a neonatal intensive care unit

Ramarao, Nalini; Belotti, Laure; Deboscker, Stéphanie; Ennahar-Vuillemin, Marylene; Launay, Jerôme de; Lavigne, Thierry; Koebel, Christelle; Escande, B; Guinebretière, Marie Helene

doi:10.1016/j.ajic.2014.01.025

Cited by 34 publications

(29 citation statements)

References 7 publications

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“…Our study, along with previous ones ( 3 , 4 , 11 – 13 ), reinforces the idea that B. cereus is an underestimated emerging pathogen that can be involved in fatal healthcare-associated infections in premature newborns. Our results indicate that all B. cereus strains display potentially pathogenic properties toward at-risk patients.…”

Section: Discussionsupporting

confidence: 90%

Virulence Analysis ofBacillus cereusIsolated after Death of Preterm Neonates, Nice, France, 2013

Lotte¹,

Hérissé²,

Berrouane³

et al. 2017

Emerg. Infect. Dis.

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Section: Discussionsupporting

confidence: 90%

Virulence Analysis ofBacillus cereusIsolated after Death of Preterm Neonates, Nice, France, 2013

Lotte¹,

Hérissé²,

Berrouane³

et al. 2017

Emerg. Infect. Dis.

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“…In addition, several cases of fulminant infections similar to anthrax, and affecting healthy persons, have also been reported [ 20 – 22 ]. Predisposing factors include intravenous drug use, surgical or traumatic wounds, intravascular catheters and prematurity due to an immature immune response and to the presence of indwelling devices in the intensive care environment of neonates [ 16 – 18 , 23 ]. Environmental reservoirs include air filtration/ventilation equipment, linen, medical devices and hands of the staff [ 9 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Bacillus cereus, a serious cause of nosocomial infections: Epidemiologic and genetic survey

Glasset

Herbin²,

Granier³

et al. 2018

PLoS ONE

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108

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Bacillus cereus is the 2nd most frequent bacterial agent responsible for food-borne outbreaks in France and the 3rd in Europe. In addition, local and systemic infections have been reported, mainly describing individual cases or single hospital setting. The real incidence of such infection is unknown and information on genetic and phenotypic characteristics of the incriminated strains is generally scarce. We performed an extensive study of B. cereus strains isolated from patients and hospital environments from nine hospitals during a 5-year study, giving an overview of the consequences, sources and pathogenic patterns of B. cereus clinical infections. We demonstrated the occurrence of several hospital-cross-contaminations. Identical B. cereus strains were recovered from different patients and hospital environments for up to 2 years. We also clearly revealed the occurrence of inter hospital contaminations by the same strain. These cases represent the first documented events of nosocomial epidemy by B. cereus responsible for intra and inter hospitals contaminations. Indeed, contamination of different patients with the same strain of B. cereus was so far never shown. In addition, we propose a scheme for the characterization of B. cereus based on biochemical properties and genetic identification and highlight that main genetic signatures may carry a high pathogenic potential. Moreover, the characterization of antibiotic resistance shows an acquired resistance phenotype for rifampicin. This may provide indication to adjust the antibiotic treatment and care of patients.

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“…B . cereus can also cause severe local or systemic non-gastrointestinal infections [ 5 – 10 ]. During infection, B .…”

Section: Introductionmentioning

confidence: 99%

The Bacterial Mfd Protein Prevents DNA Damage Induced by the Host Nitrogen Immune Response in a NER-Independent but RecBC-Dependent Pathway

et al. 2016

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Production of reactive nitrogen species is an important component of the host immune defence against bacteria. Here, we show that the bacterial protein Mfd (Mutation frequency decline), a highly conserved and ubiquitous bacterial protein involved in DNA repair, confers bacterial resistance to the eukaryotic nitrogen response produced by macrophage cells and during mice infection. In addition, we show that RecBC is also necessary to survive this stress. The inactivation of recBC and mfd genes is epistatic showing that Mfd follows the RecBC repair pathway to protect the bacteria against the genotoxic effect of nitrite. Surprisingly given the role of Mfd in transcription-coupled repair, UvrA is not necessary to survive the nitrite response. Taken together, our data reveal that during the eukaryotic nitrogen response, Mfd is required to maintain bacterial genome integrity in a NER-independent but RecBC-dependent pathway.

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Two unrelated episodes of Bacillus cereus bacteremia in a neonatal intensive care unit

Cited by 34 publications

References 7 publications

Virulence Analysis ofBacillus cereusIsolated after Death of Preterm Neonates, Nice, France, 2013

Virulence Analysis ofBacillus cereusIsolated after Death of Preterm Neonates, Nice, France, 2013

Bacillus cereus, a serious cause of nosocomial infections: Epidemiologic and genetic survey

The Bacterial Mfd Protein Prevents DNA Damage Induced by the Host Nitrogen Immune Response in a NER-Independent but RecBC-Dependent Pathway

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