Tyler Asbestos Workers Program*

Greenberg, S. Donald; Hurst, George A.; Matlage, W.T.; Miller, John M.; Hurst, Irby J.; Mabry, Linda C.

doi:10.1111/j.1749-6632.1976.tb23131.x

Cited by 19 publications

(2 citation statements)

References 6 publications

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“…possible that the use of induced sputum may have yielded fewer false negatives. Inducing sputum has been reported to significantly increase the number of positive specimens and the concentration of ABs [31,32]. However, the improvement was far lower than would be necessary to significantly improve the correlation between BAL and sputum AB counts noted here.…”

Section: Discussioncontrasting

confidence: 42%

Relevance of asbestos bodies in sputum

et al. 1996

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The presence of asbestos bodies (ABs) in sputum specimens of individuals with occupational asbestos exposure has been well-documented. The aim of this study was to determine their clinical relevance in comparison to the concentration of AB in bronchoalveolar lavage (BAL) and lung tissue.Subjects were included following a well-documented exposure of asbestos history (n=93) or BAL fluid analysis positive for ABs (n=42). The subjects with a well documented history of AB exposure were divided into three groups: heavy (Group 1, n=29); moderate (Group 2, n=31); or occasional exposure (Group 3, n=33). BAL fluid was available from all subjects, and lung tissue from 21 subjects. To assess the variability, 10 sputum positive subjects collected subsequent sputum on days 2, 7, 14, 30 and 90. ABs were determined by light microscopy after membrane filtration of specimen digests.The mean sputum AB content was highest in Group 1 (2.4±5.5 AB·mL -1 ), lower in Group 2 (0.2±0.3 AB·mL -1 ) and lowest in Group 3 (0.1±0.1 AB·mL -1 ) suggesting a correlation with cumulative exposure. However, many negative sputum samples were noted, when BAL specimens were positive. The AB content of sputum and BAL specimens did not correlate. ABs were found in sputum of all subjects with a tissue content of >1,000 AB·cm -3 , but in none with contents of <1,000 AB·cm -3 . Substantial variability of ABs was found in the five sequentially collected sputa of 10 initially positive patients (coefficient of variation 28-93%), but only two false negatives were found in these 50 samples.Thus, sputum analysis for asbestos bodies is an insensitive method for assessing the lung asbestos burden, much less sensitive than bronchoalveolar lavage fluid analysis. However, a sputum sample positive for asbestos bodies is suggestive of a high lung asbestos burden.

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Section: Discussioncontrasting

confidence: 42%

Relevance of asbestos bodies in sputum

et al. 1996

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“…1 In the 1970s, various scientific research, using newly developed techniques of cell biology, made great strides in broadening our knowledge of these cause-and effect relationships. 2 Both epidemiologic and scientific research studies point toward prevention as the single most important factor in controlling these asbestos associated diseases, [4][5][6] To accomplish the needed ongoing surveillance of workplaces where asbestos is used, the federal government in 1970 passed the Occupational Safety and Health Act (OSHA) and created the Occupational Safety and Health Administration to help support it.…”

Section: History Of Asbestos Associated Diseasesmentioning

confidence: 99%

Asbestos Lung Disease

Greenberg¹

1982

Semin Respir Crit Care Med

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Mesothelioma of childhood

Fraire

Cooper

Greenberg

et al. 1988

Cancer

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Malignant mesothelioma (MM) of childhood is a rare but important neoplasm. Eighty children with a previous diagnosis of MM were identified. Four of the 80 children had exposure to known risk factors (two had history of exposure to asbestos, one had received radiation therapy, and one had been exposed in utero to isoniazid). Tissue slides were available for independent and joint review by a panel of three pathologists in 22 of the cases. Ten were accepted as MM, nine were reclassified as other malignancies, and three were considered tumors of uncertain nature. Six of the ten children with MM were boys, and four were girls. Eight had pleural tumors, and two had peritoneal tumors. Four died at 7, 8, 18, and 48 months after diagnosis; three remained alive at 19, 20, and 59 months; and three had no follow-up. This review suggests that MM of childhood is a valid entity with a grave prognosis. The tissue diagnosis is difficult and is best made by a panel of pathologists. The available evidence does not support a causal relationship between MM and asbestos, radiation, or isoniazid.

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Tyler Asbestos Workers Program*

Abstract: It is concluded that sputum cytopathology is an excellent, simple, noninvasive, painless, and inexpensive means for early detection of malignant and premalignant lesions of the lung, and that no special techniques are necessary for the identification of ferruginous bodies.

Cited by 19 publications

References 6 publications

Relevance of asbestos bodies in sputum

Relevance of asbestos bodies in sputum

Asbestos Lung Disease

Mesothelioma of childhood

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