Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of H1-Receptor Antagonist (Olopatadine Hydrochloride)

Egami, Naoya; Kakigi, Akinobu; Takeda, Taizo; Takeda, Setsuko; Nishioka, Rie; Hyodo, Masamitsu; Yamasoba, Tatsuya

doi:10.1097/mao.0000000000000195

Cited by 11 publications

(4 citation statements)

References 19 publications

(20 reference statements)

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“…Although the immunological basis for the allergic origin of MD is not well understood, early studies in the field of otolaryngology demonstrate amelioration of vertigo, tinnitus, and hearing loss in response to the desensitization of patients to inhalant allergens and elimination diet containing food allergens (11). Animals actively sensitized with a specific Ag and subsequently exposed to the same develop endolymphatic hydrops in the inner ear (12). A clinical report has described the relationship between endolymphatic hydrops and an allergic response, which can be triggered by a food allergenIgE Ab reaction (13).…”

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confidence: 99%

Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere’s Disease

Zhang

Lyu

Guo

et al. 2022

The Journal of Immunology

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Meniere’s disease (MD) is a disorder of the inner ear characterized by episodes of spontaneous vertigo, fluctuating hearing loss, and tinnitus. Recent studies have demonstrated that IgE may play a role in the pathogenesis of MD. Patients with MD (n = 103), acoustic neuroma (n = 5), and healthy subjects (n = 72) were recruited into the study. Serum from the participants was analyzed for IgE and type 2–related cytokines. IgE and CD23 expression levels in vestibular end organs of patients, C57BL/6 mice, or mouse HEI-OC1 cells were analyzed. Finally, the role of CD23 in IgE transcytosis was assessed using HEI-OC1 cells. Serum IgE was elevated in patients with MD and positively correlated with clinical symptoms. IL-4, IL-5, IL-10, IL-13, and CD23 levels were increased in patients with MD compared with the control group. In the transcytosis assay, mouse IgE was found to be bidirectionally transported across the HEI-OC1 cell monolayer. Additionally, CD23 downregulation using a small interfering RNA approach significantly reduced the efficiency of IgE transcytosis, suggesting that IgE is transported by CD23. Furthermore, exposure to IL-4 increased CD23 expression and enhanced IgE transcytosis in the HEI-OC1 cells and primary vestibular end organs. Our study indicated that IgE may play a role in the pathophysiology of MD. In addition, CD23-mediated IgE transcytosis in the hair cells may play a critical role in initiating inflammation in the inner ear. Thus, reducing the level of IgE may be a potentially effective approach for MD treatment.

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confidence: 99%

Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere’s Disease

Zhang

Lyu

Guo

et al. 2022

The Journal of Immunology

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“…Although the notion of immune-mediated inflammation in idiopathic, sensorineural hearing loss has persisted for over six decades 16 , little progress has since been made on the nature of the participant cellular components and the mechanism through which they interact to bring about inflammatory reactions. That said, available evidences have pointed to ELS as a key immunologic interface 17 , 18 . The labyrinthine sac is believed to harbour inner ear antigens of various molecular weights 19 , which can invoke autoimmune response (type II hypersensitivity) from the host defense 20 .…”

Section: Discussionmentioning

confidence: 99%

A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo

Hahn

Kwak

Kim

et al. 2019

Sci Rep

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Ménière disease (MD), an idiopathic disorder of sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that MD may be related to or triggered by autoimmune conditions, notably Hashimoto thyroiditis and alopecia areata. These evidences led to the authors contemplating the possibility of immunological bridge between MD and the two skin conditions. The authors have tested this hypothesis with population-based cohort from the National Health Insurance Service Database of Korea. A cohort of 1.1 million patients was extracted from the database. Using χ2 tests, prevalence of the two skin disorders in relation to MD status was analysed. In MD patients, the odds ratios for having concurrent AD and vitiligo were 0.717 (95% CI, 0.535–0.962, p = 0.026) and 2.149 (95% CI, 1.396–3.308, p = 0.001), respectively. Females and older patients were more than twice likely to be affected by the two skin conditions. The relationship between vitiligo and MD was significant in younger subgroup only. Socio-economic subgroup analysis revealed the observed patterns are primarily a middle-upper class phenomenon. Uncertainty regarding temporal sequence of onset, and lack of detail on disease severity and subtype kept the study from more refined conclusion. In concluding, AD and vitiligo might be linked to MD through Treg-driven action of cellular immunity, but further big data-based investigations must follow.

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“…Immediate type of food allergy is mediated by type I hypersensitivity reaction, involving mast cells and food-specific IgE antibodies. In animal studies, Meneire's Disease could be induced by type 1 hypersensitivity which in turn, could be prevented by histamine H(1)-receptor antagonists [35]. Translated into clinical practice, a significant percentage of patients with Meniere's disease and allergy showed improvement in their symptoms of tinnitus and vertigo when receiving specific allergy therapy [34].…”

Section: Discussionmentioning

confidence: 99%

Inner Ear Disorders: Exploring Possible Links between the Endolymphatic Sac, Gall Bladder and Small Intestine

Low¹

2017

IJCAM

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Introduction: In Traditional Chinese Medicine (TCM), the gall-bladder (GB) and small intestine (SI) systems are closely associated with the ear. Acupuncture involving these meridians has been used with success in Meniere's disease where the endolymphatic sac of the inner ear plays a key role. This paper aimed to find out if the endolymphatic sac of the ear shared certain anatomical, physiological and pathological similarities with those of the GB and SI.Methods: A Medline search of the English literature with each of the words "endolymphatic sac", "gall bladder" and "small intestine", was carried out. Relevant English literature detailing the anatomy and physiology of the 3 structures were also reviewed. Results:The GB, SI & ES are found to share common anatomical features facilitating the absorption of fluid and electrolytes. In addition, physiological and pathological processes involving allergy, immune-defense, hormonal action and active transport of solutes are involved in all the 3 structures. Conclusion:If the GB, SI and ES are indeed linked functionally and/or pathologically by one or more of the common themes relating to immunity, the endocrine system as well as fluid and electrolyte homeostasis, plausible medical explanations could possibly be offered for the pathogenesis and treatment of ear disorders as perceived by TCM.

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Type 1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of H1-Receptor Antagonist (Olopatadine Hydrochloride)

Abstract: The systemic sensitization with DNP-As produced allergy-induced experimental EH by type 1 hypersensitivity allergic reaction, and the development of this EH was prevented by histamine H(1)-receptor antagonists.

Cited by 11 publications

References 19 publications

Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere’s Disease

Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere’s Disease

A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo

Inner Ear Disorders: Exploring Possible Links between the Endolymphatic Sac, Gall Bladder and Small Intestine

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