Type 1 Diabetes and Autism

Freeman, Sloane; Roberts, Wendy; Daneman, Denis

doi:10.2337/diacare.28.4.925

Cited by 47 publications

(40 citation statements)

References 14 publications

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“…16 Like PDD, type 1 diabetes comprises complex genetic disorders with multiple contributing genes, 22 and recently published data suggest that the prevalence of autism spectrum disorders in type 1 diabetes may be greater than in the general population. 23 However, the significance of our observations, like the marginal frequency of ulcerative colitis in mothers, must be evaluated considering the number of significance tests performed in our study, as one statistically significant result may be a mere chance finding.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune diseases in parents of children with infantile autism: a case—control study

Mouridsen

Rich²,

Isager

et al. 2007

Develop Med Child Neuro

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This register study compared the rates and types of autoimmune disease in the parents of 111 patients (82 males, 29 females; mean age at diagnosis 5y 5mo [SD 2y 6mo]) with infantile autism (IA) with a matched control group of parents of 330 children from the general population. All parents were screened through the nationwide Danish National Hospital Register. We inquired about 35 autoimmune diseases during an observation period of 27 years. At follow‐up the case and control mothers were identical in age (65y 7mo [SDs 9y 7mo and 9y respectively]). For case and control fathers the figures were 70 years 2 months (SD 10y 2mo) and 69 years 1 month (SD 10y 1mo) respectively. A similar proportion of case and control mothers had a diagnosis of any autoimmune disease: 10.8% versus 9.1%. For case fathers the proportion was 8.6% versus 4.6%. Two autoimmune conditions were associated with IA: ulcerative colitis in mothers (p=0.05) and type 1 diabetes in fathers (p=0.02). Additional studies are required to determine whether there is a true association between a parental history of autoimmune disease and pervasive developmental disorder in their offspring.

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Section: Discussionmentioning

confidence: 99%

Autoimmune diseases in parents of children with infantile autism: a case—control study

Mouridsen

Rich²,

Isager

et al. 2007

Develop Med Child Neuro

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show abstract

“…Metabolic effects of metformin include enhanced hepatic insulin sensitivity and reduced hepatic glucose output (2). Metfomin might reduce insulin resistance in pregnancy, decrease maternal weight gain, reduce maternal glucose levels and fetal hyperinsulinemia, and, as a consequence, reduce neonatal adiposity and birth trauma.…”

Section: Metformin In Pregnancymentioning

confidence: 99%

“…discussed metformin in pregnancy. Dr. Clifford Bailey reviewed cellular mechanisms of metformin in nonpregnant patients (2) and suggested applications in pregnancy. Professor Gerald Briggs discussed how to determine the teratogenic risk of drugs and suggested that metformin use in the first trimester may be low risk based on animal and human data.…”

Section: Metformin In Pregnancymentioning

confidence: 99%

“…The data were linked to the nationwide Hospital Discharge Register (HDR) by the end of the year 2003 using the unique personal identity number that is assigned to all residents of Finland. We included autism, Asperger disorder, pervasive developmental disorder-not otherwise specified, Rett's syndrome, and childhood disintegrative disorder in the diagnosis of ASD (2). We also linked the data of mothers of ASD cases to the HDR and reviewed hospital records in order to find out pregnancy and delivery complications related as potential risk factor for subsequent ASD in the child.…”

mentioning

confidence: 99%

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Type 1 Diabetes and Autism: Is there a link?

Harjutsalo¹,

Tuomilehto

2006

Diabetes Care

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“…In addition, adenylosuccinate lyase deficiency, Duchenne muscular dystrophy, and mitochondrial cytopathies are associated with autism (Caglayan, 2010). Some data suggest a link between Type 1 diabetes and autism (Freeman et al, 2005). In addition, autoimmunity is very prevalent in autistic subjects and in their parents and close relatives (Megson, 2000).…”

Section: Co-morbiditiesmentioning

confidence: 99%