Type 1 diabetes and gut microbiota: Friend or foe?

Hu, C.; Wong, F. Susan; Li, Wen

doi:10.1016/j.phrs.2015.02.006

Cited by 48 publications

(36 citation statements)

References 110 publications

(144 reference statements)

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“…The altered gut microbiota, such as the increased abundance of Bacteroidetes, could promote increased intestinal permeability and precede the clinical onset of T1D in animal models and pre‐diabetic and diabetic patients . In fact, the role of the gut microbiota in T1D has been suggested since 1987, and the first study in humans was performed in Finland by using stool samples from four T1D children and four matched controls . They observed that children with T1D had decreased microbiota diversity compared with controls and had a reduction in the Firmicutes : Bacteroidetes ratio (Fig.…”

Section: Type 1 Diabetesmentioning

confidence: 99%

“…In fact, the role of the gut microbiota in T1D has been suggested since 1987, and the first study in humans was performed in Finland by using stool samples from four T1D children and four matched controls . They observed that children with T1D had decreased microbiota diversity compared with controls and had a reduction in the Firmicutes : Bacteroidetes ratio (Fig. ).…”

Section: Type 1 Diabetesmentioning

confidence: 99%

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Intestinal dysbiosis and probiotic applications in autoimmune diseases

Oliveira¹,

Leite²,

Higuchi³

et al. 2017

Immunology

274

201

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SummaryIn humans, a complex interaction between the host immune system and commensal microbiota is required to maintain gut homeostasis. In this symbiotic relationship, the microbiota provides carbohydrate fermentation and digestion, vitamin synthesis and gut-associated lymphoid tissue development, as well as preventing colonization by pathobionts, whereas the host offers a niche and nutrients for the survival of the microbiota. However, when this mutualistic relationship is compromised and an altered interaction between immune cells and microorganisms occurs, the gut microbiota may cause or contribute to the establishment of infectious diseases and trigger autoimmune diseases. Researchers have made efforts to clarify the role of the microbiota in autoimmune disease development and find new therapeutic approaches to treat immune-mediated diseases. However, the exact mechanisms involved in the dysbiosis and breakdown of the gut epithelial barrier are currently unknown. Here, we provide a general overview of studies describing gut microbiota perturbations in animal models of autoimmune diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. Moreover, we include the main studies concerning dysbiosis in humans and a critical discussion of the existing data on the use of probiotics in these autoimmune diseases.

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Section: Type 1 Diabetesmentioning

confidence: 99%

Section: Type 1 Diabetesmentioning

confidence: 99%

Intestinal dysbiosis and probiotic applications in autoimmune diseases

Oliveira¹,

Leite²,

Higuchi³

et al. 2017

Immunology

274

201

View full text Add to dashboard Cite

show abstract

“…More interestingly, if a patient's parent has T1DM, the risk for developing T1DM is 5% and it becomes higher if, among the parents, the father is the diabetic patient [30]. Reports have identified more than 50 genetic risk loci related to T1DM [31] whereas gene variants occurring in a major locus named major histocompatibility complex (MHC) region, also known as human leukocyte antigen (HLA) [32] have similarly been reported to confer between 50-60% of genetic risk associated with T1DM development [33]. The genetic risk is linked with the expression of the gene by affecting the HLA protein ability to bind to antigenic peptides and their antigen presentation to T cells [34].…”

Section: Genetic Factorsmentioning

confidence: 99%

“…Recent data indicate that altered gut microbiomes have also implications in the pathogenesis of T1DM as evident by the differences in the gut microbiome profile of T1DM versus healthy controls [33]. Previous studies have reported that as healthy infants approach the toddler stage their microbiomes are seen to be healthier and even more stable.…”

Section: Environmental Factorsmentioning

confidence: 99%

Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications

et al. 2020

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Objectives Glycoproteins are organic compounds formed from proteins and carbohydrates, which are found in many parts of the living systems including the cell membranes. Furthermore, impaired metabolism of glycoprotein components plays the main role in the pathogenesis of diabetes mellitus. The aim of this study is to investigate the influence of glycoprotein levels in the treatment of diabetes mellitus. Methods All relevant papers in the English language were compiled by searching electronic databases, including Scopus, PubMed and Cochrane library. The keywords of glycoprotein, diabetes mellitus, glycan, glycosylation, and inhibitor were searched until January 2019. Results Glycoproteins are pivotal elements in the regulation of cell proliferation, growth, maturation and signaling pathways. Moreover, they are involved in drug binding, drug transportation, efflux of chemicals and stability of therapeutic proteins. These functions, structure, composition, linkages, biosynthesis, significance and biological effects are discussed as related to their use as a therapeutic strategy for the treatment of diabetes mellitus and its complications. Conclusions The findings revealed several chemical and natural compounds have significant beneficial effects on glycoprotein metabolism. The comprehension of glycoprotein structure and functions are very essential and inevitable to enhance the knowledge of glycoengineering for glycoprotein-based therapeutics as may be required for the treatment of diabetes mellitus and its associated complications.

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“…Along with evidence especially in developed country suggested the development of T1D due to the direct involvement of gut microbiota in immune-mediated pathogenesis [18]. Research studies have proven the role of altered gut microbes in the immunopathogenesis of DM; on the other hand, probiotics which have beneficial role in making healthy gut, have been suggested in DM management [19].…”

Section: Jayaswal Et Almentioning

confidence: 99%

Gut Microbiota and Diabetes Mellitus - An Interlinkage

Vijayasimha

Prabhakar

2018

Asian J Pharm Clin Res

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In recent years, the curiosity to investigate the relationship between gut microbiota and diabetes development has increased. Evidence from previous studies suggests that gut microbiota manipulation may assure to prevent diabetes development in future, primarily in susceptible individuals. Here, we reviewed special gut microbiota types proposing development of Type 1 (T1D) and Type 2 diabetes (T2D) in humans and laboratory animals. The available data we found are still inconclusive and required more attention in discriminating specific groups of gut microbiomes strongly indicating T1D and T2D development or prevention. Further, we suggested for the first time to study the gut microbiota in different ways to find the root cause of diabetes development.

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Type 1 diabetes and gut microbiota: Friend or foe?

Cited by 48 publications

References 110 publications

Intestinal dysbiosis and probiotic applications in autoimmune diseases

Intestinal dysbiosis and probiotic applications in autoimmune diseases

Targeting Glycoproteins as a therapeutic strategy for diabetes mellitus and its complications

Gut Microbiota and Diabetes Mellitus - An Interlinkage

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