Type 1 diabetes in children and adolescents is not associated with a reduced prevalence of atopy and allergic diseases

Jasser-Nitsche, Hildegard; Varga, Eva‐Maria; Borkenstein, Helmuth Martin; Höntzsch, Julia; Suppan, Elisabeth; Weinhandl, Gudrun; Pieringer, Lisa; Avian, Alexander; Fröhlich‐Reiterer, Elke

doi:10.1111/pedi.12504

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…In contrast to previous theories, other studies have shown no differences in asthma prevalence between T1DM subjects and the general population [ 26 , 71 , 72 , 73 ]. A survey of individuals with pediatric-onset T1DM in a large German/Austrian population [ 26 ] showed that the frequency of asthma in individuals with T1DM (3,4%) was similar to the prevalence of asthma in the general population (4.7% in the German population from the German KIGGS study [ 74 ] and 5.1–7.3% in the Austrian one from the ISAAC study [ 75 ]).…”

Section: Studies Reporting No Association Between Asthma and Type 1 Diabetescontrasting

confidence: 74%

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Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review

Sgrazzutti

Sansone

Attanasi

et al. 2021

IJMS

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Asthma and type 1 diabetes mellitus (T1DM) are two of the most frequent chronic diseases in children, representing a model of the atopic and autoimmune diseases respectively. These two groups of disorders are mediated by different immunological pathways, T helper (Th)1 for diabetes and Th2 for asthma. For many years, these two groups were thought to be mutually exclusive according to the Th1/Th2 paradigm. In children, the incidence of both diseases is steadily increasing worldwide. In this narrative review, we report the evidence of the potential link between asthma and T1DM in childhood. We discuss which molecular mechanisms could be involved in the link between asthma and T1DM, such as genetic predisposition, cytokine patterns, and environmental influences. Cytokine profile of children with asthma and T1DM shows an activation of both Th1 and Th2 pathways, suggesting a complex genetic-epigenetic interaction. In conclusion, in children, the potential link between asthma and T1DM needs further investigation to improve the diagnostic and therapeutic approach to these patients. The aim of this review is to invite the pediatricians to consider the potential copresence of these two disorders in clinical practice.

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Section: Studies Reporting No Association Between Asthma and Type 1 Diabetescontrasting

confidence: 74%

“…Jasser-Nitsche et al [ 73 ], in an Austrian survey of 104 T1DM children and 104 healthy controls, showed no differences in allergen sensitization rate and in the number of patients reporting allergy symptoms [ 73 ].…”

Section: Studies Reporting No Association Between Asthma and Type 1 Diabetesmentioning

confidence: 99%

Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review

Sgrazzutti

Sansone

Attanasi

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…A recent study conducted in Austria showed an allergen sensitization rate that was not significantly different between T1DM children and healthy controls (p = 0.625). Furthermore, a comparable number of patients in both groups reported allergic symptoms (p = 0.43) [61].…”

Section: T1d and Asthmamentioning

confidence: 81%

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

et al. 2021

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Historically, the lung was not listed and recognized as a major target organ of diabetic injury. The first evidence of diabetic lung involvement was published fifty years ago, with a study conducted in a population of young adults affected by type 1 diabetes (T1D). In recent years, there has been mounting evidence showing that the lung is a target organ of diabetic injury since the beginning of the disease—at the pediatric age. The deeply branched vascularization of the lungs and the abundance of connective tissue, indeed, make them vulnerable to the effects of hyperglycemia, in a way similar to other organs affected by microvascular complications. In this review, we focus on pulmonary function impairment in children and adolescents affected by T1D. We also cover controversial aspects regarding available studies and future perspectives in this field.

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“…[95-97] T1DM appears to be associated with SIgAD, although individuals with T1DM have a similar prevalence of allergy and atopy when compared with the general population. [98] Compared to 0.34%the highest estimated prevalence of T1DM among the general population of Caucasians, 11 studies have found a prevalence ranging from 0% to 6.35% among SIgAD individuals, with a weighted average of 5.12%. [1,14,20,40,66,67,81,82,87,93,94] (Table 9) Two studies made use of a control population.…”

Section: Type 1 Diabetes Mellitusmentioning

confidence: 99%

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

Odineal

Gershwin

2019

Clinic Rev Allerg Immunol

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Selective Immunoglobulin A Deficiency (SIgAD) is the most common primary immunodeficiency, defined as an isolated deficiency of IgA (less than 0.07 g/L). Although the majority of people born with IgA deficiency lead normal lives without significant pathology, there is nonetheless a significant association of IgA deficiency with mucosal infection, increased risks of atopic disease, and a higher prevalence of autoimmune disease. To explain these phenomena, we have performed an extensive literature review to define the geoepidemiology of IgA deficiency and particularly the relative risks for developing Systemic Lupus Erythematosus, hyperthyroidism, hypothyroidism, type 1 diabetes mellitus, Crohn's Disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and vitiligo; these diseases have strong data to support an association. We also note weaker associations with scleroderma, celiac disease, autoimmune hepatitis, immune thrombocytopenic purpura, and autoimmune hemolytic anemia. Minimal if any associations are noted with myasthenia gravis, lichen planus, and multiple sclerosis. Finally, more recent data provide clues on the possible immunologic mechanisms that lead to the association of IgA deficiency and autoimmunity; these lessons are important for understanding the etiology of autoimmune disease. 2 3 Introduction:

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Type 1 diabetes in children and adolescents is not associated with a reduced prevalence of atopy and allergic diseases

Abstract: The present cohort study shows the same prevalence of allergy and atopy in a pediatric diabetes population compared to healthy controls. Diabetes per se does not seem to influence the development of allergies.

Cited by 10 publications

References 25 publications

Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review

Coaggregation of Asthma and Type 1 Diabetes in Children: A Narrative Review

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency

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