Type 2 Diabetes in Asians: Prevalence, Risk Factors, and Effectiveness of Behavioral Intervention at Individual and Population Levels

Weber, Mary Beth; Oza-Frank, Reena; Staimez, Lisa R.; Ali, Mohammed K.; Narayan, K.M. Venkat

doi:10.1146/annurev-nutr-071811-150630

Cited by 62 publications

(50 citation statements)

References 159 publications

(172 reference statements)

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“…39 Such estimates are broadly comparable with ours, the lower estimate for Asia being likely caused by a lower prevalence of diabetes in those populations. 40 Heavy alcohol drinking, but not low to moderate consumption, has been associated with an increased risk of pancreatic cancer. [17][18][19] A meta-analysis of 21 case-control and 11 cohort studies reporting a 22% excess risk for pancreatic cancer for heavy drinkers (≥3 drinks per day) indicated that only 2% to 3% of all pancreatic cancer cases could be attributed to alcohol consumption in a population with 10% to 15% of heavy drinkers.…”

Section: Discussionmentioning

confidence: 99%

Population Attributable Risk for Pancreatic Cancer in Northern Italy

Rosato¹,

Polesel²,

Bosetti³

et al. 2015

Pancreas

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Section: Discussionmentioning

confidence: 99%

Population Attributable Risk for Pancreatic Cancer in Northern Italy

Rosato¹,

Polesel²,

Bosetti³

et al. 2015

Pancreas

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“…Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and environment factors [1]. Diabetes mellitus is generally classified into 4 groups based on their pathogenesis with T2DM as the most frequent group (90-95%).…”

Section: Introductionmentioning

confidence: 99%

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Sunita

Sadewa

Farmawati

2015

Egyptian Journal of Medical Human Genetics

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KEYWORDST2DM; E23K polymorphism of KCNJ11; HOMA-b; Individuals with family history of T2DM; Individuals without family history of T2DM Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and also environmental factors. Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, an ATP-sensitive potassium channel-coding gene, contributes to insulin secretion.Objectives: This research aimed to investigate E23K polymorphism in KCNJ11 gene and insulin secretion in individuals with family history of T2DM (cases) and without family history of T2DM (controls).Method: This research was a case-control study involving 34 cases and 34 controls. E23K polymorphism of KCNJ11 was detected with PCR-RFLP. All of the obtained data were statistically analyzed with T-test, Mann-Whitney U-test, Chi-Square and One-Way ANOVA.Result: Frequency of AA genotype in individuals with family history of T2DM (41%) was higher than in individuals without family history of T2DM (6%) (p = 0.001). Frequency of A allele in individuals with family history of T2DM (68%) was higher than in individuals without family history of T2DM (38%) (p = 0.001). The risk of A allele in individuals with family history of T2DM was 3 times higher than in individuals without family history of T2DM (p = 0.001, OR 3.38, CI 95% 1.67-6.84). Homeostasis Model Assessment b (HOMA-b) values of AA genotype (85.44% ± 39.55) were lower than that of GA (212.20% ± 79.30) and GG (254.00% ± 61.98) genotypes (p = 0.000).Conclusion: The risk of having A allele in individuals with family history of T2DM is higher than that in individuals without family history of T2DM. HOMA-b values of AA genotype are lower than that of GA and GG genotypes.

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“…Besides the rapid growth of the Non-Hispanic Asian population in the U.S., the urgent need of assessing metabolic dysfunction in this population also lies in the observation that Non-Hispanic Asian populations around the world are at increased risk for metabolic symptoms that may contribute to the development of type 2 diabetes [7,8] . Cross-sectional studies that compare Non-Hispanic Asian populations to other racial/ethnic groups in North America suggest that Non-Hispanic Asians experience an elevated prevalence of metabolic risk relative to other racial/ethnic groups [9][10][11] . Nativity to the U.S. has important effects on the development of metabolic dysfunction and type 2 diabetes among Non-Hispanic Asians.…”

Section: Introductionmentioning

confidence: 99%

Risk of Type 2 Diabetes Among Us and Foreign Born Non-Hispanic Asians: Evidence From Nhanes

Jackson¹

2015

JDO

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Aims/Introduction: The purpose of this study was to compare risks for metabolic dysfunction and type 2diabetes among Non-Hispanic Asian and Non-Hispanic white adults using new nationally representative data in the U.S. We compared the metabolic profiles of U.S.-born vs. foreign -born Non-Hispanic Asian adults. Materials and Methods: This study used NHANES 2011-2012 adult data for Non-Hispanic Asians (n=827) and Non-Hispanic Whites (n=2,108). Standardized risk threshold cutoffs for blood pressure, lipids, and glucose were used to determine metabolic dysfunction. Logistic regression models were used to estimate odds of metabolic dysfunction. Covariates included age, sex, education level, marital status, BMI, serum cotinine exposure (for smoking), and nativity. Results: Compared to Non-Hispanic Whites, Non-Hispanic Asians were at increased risk for HDL≤40 mg/dL (men) and≤50 mg/dL (women) (OR=1.78, 95% CI=1.02-3.11), HbA1c≥ 5.6 % (OR=3.23, 95% CI= 1.79-5.90), and HbA1c≥6.5 % (OR=3.32, 95% CI=1.58-6.98). Relative to U.S.-born Non-Hispanic Asians, foreign-born Non-Hispanic Asians had elevated risk for HbA1c ≥ 6.5 % (OR=1.94, 95% CI=1.24-3.02), total cholesterol ≥ 200 mg/dL (OR= 1.77, 95 %CI = 1.31-2.39) and LDL ≥ 100 mg/dL (OR=1.79, 95% CI=1.23-2.59). Conclusions: This is the first analysis of metabolic dysfunction and type 2 diabetes between U.S vs foreign-born Non-Hispanic Asians using nationally representative data. Non-Hispanic Asian immigrants appear to be the most at risk. Independent of BMI, Non-Hispanic Asians were at significantly higher risk for low HDL and type 2 diabetes compared to Non-Hispanic white adults.

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Type 2 Diabetes in Asians: Prevalence, Risk Factors, and Effectiveness of Behavioral Intervention at Individual and Population Levels

Cited by 62 publications

References 159 publications

Population Attributable Risk for Pancreatic Cancer in Northern Italy

Population Attributable Risk for Pancreatic Cancer in Northern Italy

Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Risk of Type 2 Diabetes Among Us and Foreign Born Non-Hispanic Asians: Evidence From Nhanes

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