Type 2 Diabetes Increases Risk for Obesity Among Subsequent Generations

Chathurvedi, Deepti; Khadgawat, Rajesh; Kulshrestha, Bindu; Gupta, Nidhi; Joseph, Angela Ann; Diwedi, Sadanand; Ammini, Ariachery C.

doi:10.1089/dia.2008.0126

Cited by 16 publications

(11 citation statements)

References 39 publications

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“…In an earlier study from Delhi [10], abnormal glucose tolerance of 24.8% has been reported amongst overweight and obese children in 5-18 years of age and is comparable to present study where impaired glucose tolerance was present in 20% of combined overweight and obese adolescents.…”

Section: Discussionsupporting

confidence: 90%

Glucose Tolerance in Overweight and Obese North Indian Adolescents

et al. 2011

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The present analytic study was planned to study the impact of overweight and obesity on glucose tolerance in adolescents. Thirty overweight (BMI analogue ≥ 25-29.9 kg/m(2)) and 30 obese (BMI analogue ≥ 30 kg/m(2)) adolescents were included as cases and 30 healthy age and sex matched adolescents comprised the control group. All the study participants were subjected to oral glucose tolerance test (OGTT) as a measure of glucose tolerance.Means of fasting blood glucose levels in normal, overweight and obese groups were 84.5 mg/dl, 86.7 mg/dl and 94.8 mg/dl respectively. Means of two hourly blood glucose levels in normal, overweight and obese groups were 105.8 mg/dl, 117 mg/dl and 127.1 mg/dl respectively. Oral Glucose tolerance test (OGTT) was normal in all the participants from control group but was impaired in four overweight adolescents. In obese group, OGTT was impaired in eight subjects and one obese child had fasting and 2 hourly blood glucose levels in diabetic range.

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Section: Discussionsupporting

confidence: 90%

Glucose Tolerance in Overweight and Obese North Indian Adolescents

et al. 2011

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“…[33] Hyperinsulinemia itself may be a primary metabolic defect and obesity may be a consequence of hyperinsulinemia. [634]…”

Section: Discussionmentioning

confidence: 99%

“…[2–5] There seems to be a vicious cycle, where obesity increases risk for T2DM and a family history of T2DM increasing the risk for obesity. [16] Parental history of T2DM is one of the dominant risk factors for development of T2DM. [7] The phenotype varies depending on which parent is affected and if the child was exposed to hyperglycemia in utero.…”

Section: Introductionmentioning

confidence: 99%

Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance

Praveen

Sahoo

Khurana

et al. 2012

Indian J Endocr Metab

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Aims:The aim was to study the effect of family history of type 2 diabetes mellitus (T2DM) on insulin sensitivity and β-cell function in normoglycemic offspring.Material and Methods:Offspring of T2DM patients (cases) and individuals without family history of T2DM (controls) were the subjects for this cross-sectional study. All participants underwent 75 g OGTT and samples were collected for plasma insulin, C-peptide, and proinsulin at 0, 30, 60, and 120 minutes.Results:A total of 271 cases (age 22 ± 10 years; 53% males) and 259 controls (28 ± 10 years, 66% males) were enrolled for the study. BMI, plasma insulin, C-peptide, proinsulin, HOMA-IR, and insulinogenic index (0-120) were significantly higher and whole-body insulin sensitivity (WBISI) and disposition index (0-120) [DI 120] were lower in cases compared to controls. After adjusting for BMI, proinsulin at 120 minutes, area under the curve (AUC) of proinsulin (during OGTT) and AUC proinsulin/AUC C-peptide were significantly higher in cases. Cases were subdivided into four groups according to inheritance pattern; paternal DM (PDM), maternal DM (MDM), grandparental DM (GPDM), and both parents DM (BPDM). The magnitude of differences varied with relationship (greater when both parents and grandparents were affected). Mean HOMA-IR was higher by 127% and 50% and DI 120 was lower by 33% and 18% (adjusted for age and gender) in the BPDM and GPDM groups respectively compared to controls.Conclusions:We observed higher BMI, plasma insulin, C-peptide, and proinsulin and lower insulin sensitivity and β-cell compensation in normoglycemic offspring of T2DM subjects compared to controls. Differences were greater when both parents and grandparents had T2DM.

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“…Seventy-five of the 109 children and adolescents attending our hospital for overweight or obesity had one or more family members with diabetes mellitus. 3 Insulin remedication, and patients on weight loss medication were excluded.…”

Section: Introductionmentioning

confidence: 99%