Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practice

Tadić, Marijana; Cuspidi, Cesare

doi:10.1016/j.acvd.2015.01.009

Cited by 112 publications

(92 citation statements)

References 63 publications

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“…Studies on T2DM and risk of atrial fibrillation have reported equivocal results [6,7,20]. The disparate findings may partly be due to limited statistical power and residual confounding as few studies adjusted for other major risk factors such as obesity [7], which was a strong confounder in the present study.…”

Section: Discussioncontrasting

confidence: 46%

“…However, less is known about the relationship of T2DM with other CVD outcomes, such as aortic valve stenosis, abdominal aortic aneurysm, and intracerebral hemorrhage, and studies on T2DM and atrial fibrillation are inconclusive [6,7]. Most data on type 1 diabetes mellitus (T1DM) in relation to risk of CVD derive from retrospective medical record review studies (cohorts of T1DM patients exclusively), with standardized mortality or incidence ratio of any CVD, coronary heart disease, or stroke as the outcome [8].…”

Section: Introductionmentioning

confidence: 99%

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Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases

Larsson

Wallin

Håkansson

et al. 2018

International Journal of Cardiology

165

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Background:The association between type 1 diabetes mellitus (T1DM) and specific cardiovascular diseases (CVD) is uncertain. Furthermore, data on type 2 diabetes mellitus (T2DM) in relation to risk of aortic valve stenosis, atrial fibrillation, abdominal aortic aneurysm, and intracerebral hemorrhage are scarce and inconclusive. We examined the associations of T1DM and T2DM with incidence of seven CVD outcomes. Methods: This study comprised 71,483 Swedish adults from two population-based prospective cohorts. T1DM and T2DM diagnosis and incident CVD cases were ascertained through linkage with the population-based registers. Results: T1DM was associated with myocardial infarction (hazard ratio [HR] 3.26; 95% confidence interval [CI] 2.47-4.30), heart failure (HR 2.68; 95% CI 1.76-4.09), and ischemic stroke (HR 2.61; 95% CI 1.80-3.79). Increased risk of myocardial infarction, ischemic stroke, and heart failure was also observed in T2DM patients and the magnitude of the associations increased with longer T2DM duration. T2DM was also associated with an increased risk of aortic valve stenosis (HR 1.34; 95% CI 1.05-1.71) and with lower risk of abdominal aortic aneurysm (HR 0.57; 95% CI 0.40-0.82) and intracerebral hemorrhage (HR 0.51; 95% CI 0.30-0.88). Only long-term T2DM (≥20 years) was associated with an increased risk of atrial fibrillation (HR 1.44; 95% CI 1.02-2.04). Conclusion: T1DM and T2DM are associated with increased risk of major CVD outcomes. Trial registration: The Cohort of Swedish Men and the Swedish Mammography Cohort are registered at clinicaltrials.gov as NCT01127711 and NCT01127698, respectively.

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Section: Discussioncontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases

Larsson

Wallin

Håkansson

et al. 2018

International Journal of Cardiology

165

View full text Add to dashboard Cite

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“…According to other studies AF was less common in women [1,4,11,12,13,14]. The mean age of our AF population was significantly higher (69.6 years) compared to patients in sinus rhythm (64.4 years), a finding confirmed also by other authors [1,10,11,12,13].…”

Section: Discussionsupporting

confidence: 90%

Risk Factors, Co-Morbidities and Treatment of In-Hospital Patients with Atrial Fibrillation in Bulgaria

et al. 2018

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Background and objectives: Atrial fibrillation (AF) is the most common arrhythmia worldwide and a major risk factor for cardiovascular complications. Our study aimed to investigate the prevalence, risk factors, demographics, co-morbidities and treatment of AF among in-hospital Bulgarian patients. Materials and Methods: A cross-sectional study including 1027 consecutive patients (n = 516, 50.2% males) with a mean age of 67.6 ± 11.3 years, hospitalized for any reason from 1 May until 31 December 2016 in one of the largest internal clinics in Bulgaria, was carried out. Results: Atrial fibrillation was diagnosed in 634 (61.7%) patients. The prevalence of modifiable AF risk factors was as follows: heart failure, 98.9%; arterial hypertension (HTN), 93.5%; valvular heart disease, 40.9%; chronic lung disease, 26.7%; type 2 diabetes mellitus, 24.9%; thyroid disease, 16.9%; and ischemic heart disease, 11.2%. Univariate logistic regression analysis identified the following risk factors with strongest impact on AF: left ventricular ejection fraction <40% (odds ratio (OR) = 1.951, 95% confidence interval (CI) 1.208–3.151), valvular heart disease (OR = 1.926, 95% CI 1.134–3.862), left ventricular ejection fraction 40–49% (OR = 1.743, 95% CI 1.248–3.017), HTN (OR = 1.653, 95% CI 1.092–3.458). History of ischemic stroke was present in 14.4% of the patients with AF. Oral antithrombotic drugs were prescribed to 85.7%: direct oral anticoagulants to 37.9%, vitamin K antagonists to 43.2%, and antiplatelets to 4.6%. Heart rate control medications and antiarrhythmics were prescribed to 75.4% and 40.2%, respectively. Conclusions: Atrial fibrillation was highly prevalent among our study population. Reduced and mid-range left ventricular ejection fraction, valvular heart disease, and HTN were the risk factors with the strongest association with AF. Although a large number of our AF patients were administered antithrombotic treatment, the prescription rate of oral anticoagulants should be further improved.

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“…All of these metabolic changes lead to endothelial dysfunction, abnormal activation of the renin-angiotensin-aldosterone system, and acceleration of atherogenesis, which could be responsible for AF occurrence. Diabetes could also cause structural, electrical, electromechanical, and autonomic remodeling [9]. These abnormalities may lead to the development of AF in diabetic people [10].…”

Section: Discussionmentioning

confidence: 99%

Assessment of atrial electromechanical delay and P-wave dispersion in patients with type 2 diabetes mellitus

Demir

Avcı

Kaya

et al. 2016

Journal of Cardiology

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Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practice

Cited by 112 publications

References 63 publications

Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases

Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases

Risk Factors, Co-Morbidities and Treatment of In-Hospital Patients with Atrial Fibrillation in Bulgaria

Assessment of atrial electromechanical delay and P-wave dispersion in patients with type 2 diabetes mellitus

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