Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0-20 years

Neu, Andreas; Feldhahn, Lutz; Ehehalt, Stefan; Hub, R.; Ranke, Michael B.

doi:10.1111/j.1399-5448.2009.00528.x

Cited by 54 publications

(51 citation statements)

References 11 publications

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“…Although the Princeton study recently showed that undiagnosed type 2 diabetes is very uncommon in adolescents and that this has not changed over the last decades [49], the findings from the Princeton study probably cannot be extrapolated to countries in which patients have only limited access to healthcare and/or the healthcare system has a suboptimal quality. Second, the quality of detection and classification of type 2 diabetes might differ between healthcare providers [29,32,35,36]. The Netherlands (1998) [37] Turkey, Ankara (not specified) [18] UK (2000) [27] UK (1998) [41]Fig.…”

Section: Discussionmentioning

confidence: 99%

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

et al. 2013

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Aims/hypothesis This study aimed to systematically review what has been reported on the incidence and prevalence of type 2 diabetes in children and adolescents, to scrutinise the methodological issues observed in the included studies and to prepare recommendations for future research and surveillances. Methods PubMed, the Cochrane Database of Systematic Reviews, Scopus, EMBASE and Web of Science were searched from inception to February 2013. Population-based studies on incidence and prevalence of type 2 diabetes in children and adolescents were summarised and methodologically evaluated. Owing to substantial methodological heterogeneity and considerable differences in study populations a quantitative meta-analysis was not performed. Results Among 145 potentially relevant studies, 37 population-based studies met the inclusion criteria. Variations in the incidence and prevalence rates of type 2 diabetes in children and adolescents were mainly related to age of the study population, calendar time, geographical regions and ethnicity, resulting in a range of 0-330 per 100,000 personyears for incidence rates, and 0-5,300 per 100,000 population for prevalence rates. Furthermore, a substantial variation in the methodological characteristics was observed for response rates (60-96%), ascertainment rates (53-99%), diagnostic tests and criteria used to diagnose type 2 diabetes. Conclusions/interpretation Worldwide incidence and prevalence of type 2 diabetes in children and adolescents vary substantially among countries, age categories and ethnic groups and this can be explained by variations in population characteristics and methodological dissimilarities between studies.

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Section: Discussionmentioning

confidence: 99%

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

et al. 2013

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“…Studies of populationbased childhood diabetes registries in Norway, Poland and Germany estimated the minimum prevalence of monogenic diabetes as 3.1/100 000 in Norwegian children, 14 4.2-4.6/100 000 in Polish children, 15 2.39/100 000 in German children 16 and 2.1/100 000 in American children. 17 The frequency of the different genetic subtypes is variable and greatly depends on the clinical recruitment (either paediatric or adult) and on the geographic origin of tested patients.…”

Section: Analytical Validationmentioning

confidence: 99%

Clinical utility gene card for: Maturity-onset diabetes of the young

et al. 2014

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“…The minimum prevalence of MODY was reported to be 1.1-4.2% of patients with diabetes or 2.4-4.6 cases per 100,000 [9][10][11][12][13][14][15][16]. In Russian population the frequency of MODY 2 and MODY 3 possibly are the same unlike in other countries [17].…”

Section: Mody Incidence and Prevalencementioning

confidence: 99%

Maturity onset diabetes of the young: Diagnosis and treatment options

Covanţev¹,

Chiriac²,

Perciuleac³

et al. 2016

Russ. Open Med. J.

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Diabetes is a complicated disease, so multiple factors are involved in its development. Nevertheless some of the patients with type 1 and 2 diabetes mellitus have a monogenic form of this disease which has different treatment options and usually fewer complications. It is estimated that about 5% of patients with type 2 diabetes melitus (T2DM) and about 10% of type 1 diabetes melitus (T1DM) are misdiagnosed and have maturity onset diabetes of the young (MODY). We present a review study of the management of most frequent monogenic forms of diabetes such as MODY 1, 2 and 3 and the possibilities of their diagnosis including in resource limited situations.

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Type 2 diabetes mellitus in children and adolescents is still a rare disease in Germany: a population-based assessment of the prevalence of type 2 diabetes and MODY in patients aged 0-20 years

Abstract: The prevalence of T2DM and MODY is considerably lower than the prevalence of type 1 diabetes. Type 2 diabetes thus continues to be a rare disease in children and adolescents in Germany, as is also the case in other European countries.

Cited by 54 publications

References 11 publications

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches

Clinical utility gene card for: Maturity-onset diabetes of the young

Maturity onset diabetes of the young: Diagnosis and treatment options

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