Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities

Lu, Fanghong; Wang, Nan; Zou, Xin; Rao, Jingjing

doi:10.1007/s11684-011-0127-9

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…WBV also observed to decrease in LC patients with more severe fibrosis. Among the three groups, patients with NAFLD had the highest blood viscosity, and this is consistent with the results of previous studies (1617192021). It is commonly known through many previous studies that increased blood viscosity is related to increased incidence and mortality of cardio-cerebrovascular disease (2223242526272829).…”

Section: Discussionsupporting

confidence: 92%

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

et al. 2016

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Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = −0.25, diastolic: r = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.

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Section: Discussionsupporting

confidence: 92%

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

et al. 2016

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“…Indeed, a fatty liver is associated with the metabolic syndrome, with insulin resistance being a prominent feature, regardless of BMI (26). Our observation that liver size was positively correlated with A1c levels within the diabetes group confirms the notion that an enlarged and fatty liver is associated with poor glucose control (48) and hemorheological abnormalities (12).…”

Section: Discussionsupporting

confidence: 81%

Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes

Davidson

Kelley

Heshka

et al. 2014

Journal of Applied Physiology

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Whether lean body mass (LBM) composition, especially skeletal muscle and abdominal organs, differs in adults with type 2 diabetes (T2DM) compared with nondiabetic healthy controls has not been investigated. A subset of African-American and Caucasian participants with T2DM from the Look AHEAD (Action for Health in Diabetes) trial had body composition assessed and compared with a sample of healthy controls. Skeletal muscle mass (SMM), liver, kidneys, and spleen mass were quantified using a contiguous slice magnetic resonance imaging (MRI) protocol. Cardiac mass was quantified by either a cardiac gated MRI protocol or by echocardiography. MRI volumes were converted to mass using assumed densities. Dual-energy X-ray absorptiometry assessed LBM. Using general linear models adjusted for height, weight, sex, age, race, and interactions of diabetes status with race or sex, persons with T2DM (n ϭ 95) had less LBM (49.7 vs. 51.6 kg) and SMM (24.1 vs. 25.4 kg) and larger kidneys (0.40 vs. 0.36 kg) than controls (n ϭ 76) (all P Ͻ 0.01). Caucasians with T2DM had larger livers (1.90 vs. 1.60 kg, P Ͻ 0.0001) and spleens (0.29 vs. 0.22 kg, P Ͻ 0.01), and T2DM men had less cardiac mass than controls (0.25 vs. 0.30 kg, P Ͻ 0.001). In this sample, T2DM is characterized by less relative skeletal muscle and cardiac mass in conjunction with larger kidneys, liver, and spleen. Further investigation is needed to establish the causes and metabolic consequences of these race-and sex-specific organ mass differences in T2DM. African American; Caucasian; magnetic resonance imaging; kidneys; liver; spleen THE CHARACTERIZATION OF BODY composition in persons with type 2 diabetes mellitus (T2DM) has been largely limited to fat distribution and its effects on metabolic disease (2,3,23,24,40,(43)(44)(45). Because skeletal muscle mass is the major site of glucose disposal and insulin uptake (52), it is of clinical importance to know whether this metabolically important tissue, which constitutes ϳ75% of total body lean mass in healthy adults (46), is preserved in persons with T2DM. Longitudinal data in older adults indicate that the age-associated reduction in thigh cross-sectional area and appendicular lean mass is accelerated in women with T2DM compared with healthy controls, but this difference was not found in men (35). Another possible contributor to the apparent differences in the quantity of lean tissue mass lost in individuals with T2DM may be the effect of race. Recent evidence links the established energy expenditure differences between African Americans and Caucasians (18, 29) to discrepancies in high-metabolic-rate organ masses such as liver, kidneys, heart, spleen, and brain (15). Whether these sex-and race-dependent effects on skeletal muscle or organ mass affect lean tissue preservation in persons with diabetes, a disease state that directly affects protein metabolism (19,37) and may influence the relative size of lean tissues and organs, is still unknown.The primary aim of this study was to assess lean body mass (LBM), skeletal muscl...

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“…It has been largely demonstrated that hemorheological disorders are linked to insulin resistance, type 2 diabetes mellitus, and obesity (10,11). Those metabolic disorders are strictly linked to the development and progression of NASH (19,20).…”

Section: Discussionmentioning

confidence: 99%

“…(MS), and cardiovascular disease (9)(10)(11). In particular RDW has been demonstrated to be a biomarker of cardiovascular disease, because it appears to reflect a state of chronic inflammation and oxidative stress, which are, as above mentioned, also physiopathologically involved in NAFLD development and progression (12).…”

Section: What Is Newmentioning

confidence: 99%

Elevated Hemoglobin Level Is Associated With Advanced Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease

Giorgio

Mosca

Alterio

et al. 2017

J. pediatr. gastroenterol. nutr.

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities

Cited by 7 publications

References 17 publications

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes

Elevated Hemoglobin Level Is Associated With Advanced Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease

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