Type 73 human papillomavirus in esophageal squamous cell carcinoma: A novel association

West, A. Brian; Soloway, Gregory; Lizarraga, Gail; Tyrrell, Lynda; Longley, Jack

doi:10.1002/(sici)1097-0142(19960615)77:12<2440::aid-cncr4>3.0.co;2-q

Cited by 24 publications

(7 citation statements)

References 26 publications

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“…HPV DNA-positive tumors contained, besides HPV 16 or 18, a spectrum of mucosal types such as HPV 6, 30, 51, 52, 57 or 73 [6,26,41]. Togawa et al [37] detected in 14% of esophageal SCC a DNA sequence related to HPV types associated with the skin disease epidermodysplasia verruciformis (ev), which was confirmed recently by the demonstration of HPV 9, 20, 24 and/or 25 that are all classical ev-associated HPVs [9].…”

Section: Introductionmentioning

confidence: 66%

Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses

Awerkiew

Bollschweiler

Metzger

et al. 2003

Medical Microbiology and Immunology

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Esophageal squamous cell carcinomas ( n=23) and adenocarcinomas ( n=14) from German patients were tested for the presence of human papillomavirus (HPV) and Epstein-Barr-Virus (EBV) DNA. No DNA for either genital HPV or epidermodysplasia verruciformis-associated HPV was detected in any tumor. In contrast, 35% of squamous cell carcinomas and 36% of adenocarcinomas were shown to contain EBV DNA by nested polymerase chain reaction.

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Section: Introductionmentioning

confidence: 66%

Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses

Awerkiew

Bollschweiler

Metzger

et al. 2003

Medical Microbiology and Immunology

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“…HPV 73 was initially found in SCC on digits but has also been observed in cervical carcinomas (0·7%), oral warts and oesophageal SCC. 26–28 …”

Section: Discussionmentioning

confidence: 99%

Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers

Forslund

Nordin

Hansson

2000

British Journal of Dermatology

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Human papillomavirus (HPV), especially type 16, is causally involved in the pathogenesis of anogenital cancer. There is an increasing number of reports of HPV infections in squamous cell carcinoma (SCC) of the fingers. A search of the Swedish cancer register covering the period 1958-94 inclusive for women with a history of genital and upper extremity SCC revealed 63 cases. Archival material from both cervical and cutaneous lesions was traced and analysed for the presence of HPV DNA in 32 of these patients. A newly developed 'neighbour primer' polymerase chain reaction (PCR) for HPV 16 DNA, aimed at overcoming the obstacle of cross-linked target DNA, was shown to be superior to conventional general and type-specific HPV PCR tests. HPV DNA was significantly more frequently found in digital tumours than in tumours at other cutaneous sites of the upper extremities [67% (10 of 15) vs. 7% (three of 43); P < 0.001]. Among 13 patients with a history of both cervical and finger SCC, HPV 16 was found in cervical samples from seven patients. From five of these seven patients, HPV 16 was also present in the corresponding finger lesions. The results support the hypothesis of a possible transmission of patients' genital HPV infections to fingers.

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“…9,11 HPV 73 has been reported to be the most common type of HPV found in benign and malignant esophageal tumors. 13,14 However, no serological study has examined the association between HPV 73 and the risk of ESCC.The effect of HPV on esophageal and gastric adenocarcinomas has not been as extensively studied. Four of the seroepidemiological studies that evaluated the association between HPV and ESCC also reported data on its association with esophageal adenocarcinomas, gastroesophageal junction adenocarcinomas, or gastric adenocarcinomas.…”

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confidence: 99%

mentioning

confidence: 99%

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Kamangar

Qiao

Schiller

et al. 2006

Intl Journal of Cancer

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Each year, esophageal and gastric cancers cause more than 900,000 deaths worldwide. Human papilloma virus (HPV), especially type 16, has been suggested to have a role in the etiology of esophageal cancer, however, the results of previous seroepidemiological studies have not been consistent. We conducted a large prospective study to examine the association between serum antibodies to HPV 16, HPV 18 and HPV 73 and subsequent development of esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and gastric noncardia adenocarcinoma (GNCA) in a high-risk population for these cancers in Linxian, China. Case and control subjects for this study were selected from the 29,584 participants of the Linxian General Population Trial. Prediagnostic serum samples from 99 cases of ESCC, 100 cases of GCA, 70 cases of GNCA, and 381 age-and sex-matched controls were selected for this study. The presence of antibodies to HPV virus-like particles was determined by type-specific enzyme-linked immunosorbent assays. Fewer than 15% of ESCC, GCA, or GNCA cases were positive for each HPV type, and no significant associations were found. The adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for HPV 16 seropositivity and ESCC, GCA, and GNCA risk were 1.6 (0.8-3.3), 1.3 (0.6-2.8) and 0.4 (0.1-1.6), respectively. The comparable ORs (95% CIs) for HPV 18 were 1.0 (0.4-2.2), 0.9 (0.4-2.1) and 1.5 (0.6-3.4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China. ' 2006 Wiley-Liss, Inc.Key words: esophageal cancer; human papillomavirus; serology Oncogenic types of human papillomavirus (HPV), most notably HPV 16 and HPV 18, are recognized as the most significant risk factors for cervical cancer. 1 The role of HPV in the etiology of cancers of vulva, anus, penis and oropharyngeal cavity has also been established. 2 The role of HPV in the etiology of esophageal cancer, however, remains controversial. Syrjanen first suggested a role for HPV in the etiology of esophageal squamous cell carcinoma (ESCC) in 1982, based on observing characteristic histological findings suggesting the presence of HPV in benign esophageal epithelia and malignant esophageal tumors. 3 During the past 20 years, several studies have used a variety of techniques, including detection of HPV DNA in esophageal tumor tissues and serologic methods, to examine the association between exposure to HPV and risk of ESCC. 4 The results of HPV DNA studies have not been consistent: case series using polymerase chain reaction (PCR) have found evidence for the presence of HPV in the tumor tissues varying from 0 to 67%. 4 Type-restricted serologic assays for different HPV types using virus-like particles were first developed in the mid-1990s, 5 and were subsequently shown to be relatively specific for each HPV type. 6 Seroreactivity to HPV 16 is a strong marker of continuous past exp...

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Type 73 human papillomavirus in esophageal squamous cell carcinoma: A novel association

Cited by 24 publications

References 26 publications

Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses

Esophageal cancer in Germany is associated with Epstein-Barr-virus but not with papillomaviruses

Mucosal human papillomavirus types in squamous cell carcinomas of the uterine cervix and subsequently on fingers

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

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