Type I Fiber Atrophy and Internal Nuclei

Peyronnard, Jean‐Marie

doi:10.1001/archneur.1982.00510200062014

Cited by 8 publications

(1 citation statement)

References 26 publications

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“…An extreme example of this phenomenon is observed in centronuclear myopathy, where 20-100% of fibers demonstrate this abnormality. (24-25) Internal nuclei may also be significantly increased in myotonic muscular dystrophy and has been previously reported to affect approximately15% of fibers. In myotonic musclar dystrophy type I fibers show a predominance of internal nuclei as opposed to myotonic muscular dystrophy type II where internal nuclei are more commonly seen in type II fibers.…”

Section: Interpreting Muscle Biopsy Resultsmentioning

confidence: 96%

Muscle Biopsy Evaluation in Neuromuscular Disorders

Joyce

Oskarsson

Jin

2012

Physical Medicine and Rehabilitation Clinics of North America

141

107

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Synopsis Muscle biopsy is a commonly ordered diagnostic procedure, used by clinicians who evaluate patients with weakness suspected to be caused by muscle disease. This article reviews the indications for a muscle biopsy, and then serves as a step-by-step guide reviewing the processes of muscle selection through to interpreting the biopsy report. The goal of this article is to aid the clinician in preparing for a muscle biopsy procedure so that they may avoid common pitfalls and obtain optimal results from this minimally invasive procedure. We review the basic anatomical structure of normal muscle to provide a foundation for understanding common patterns of pathologic change observed in muscle disease, and then present both common and disease-specific histopathologic findings, focused for illustrative purposes on a select group of neuromuscular diseases.

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Section: Interpreting Muscle Biopsy Resultsmentioning

confidence: 96%