Type-II CdS/ZnSe core/shell heterostructures: UV–vis absorption, photoluminescence and Raman scattering studies

Ca, Nguyễn Xuân; Lien, Vu Thi Kim; Nghia, Nguyen Xuan; Chi, Thuy; Phan, The‐Long

doi:10.1016/j.mseb.2015.07.003

Cited by 16 publications

(1 citation statement)

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“…Colloidal quantum dots (QDs) with high photoluminescence quantum yields (PL QYs), high resistance to photobleaching and chemical and physical degradations, and excellent biocompatibility have proven to be unique optical materials in various bio-related applications, − including visualization of cellular processes, − in vitro and in vivo labeling and imaging, − targeted drug delivery, , gene sequencing, , and quantitative bio-molecule detection. , Particularly, colloidal QDs have been considered as ideal fluorescent labeling materials for high-sensitivity protein detections in clinical diagnosis . Since Goldman and co-workers’ pioneer work on the successful application of QDs to fluoroimmunoassays ( i .…”

Section: Introductionmentioning

confidence: 99%

Thick-Shell CdSe/ZnS/CdZnS/ZnS Core/Shell Quantum Dots for Quantitative Immunoassays

Yuan

et al. 2021

ACS Appl. Nano Mater.

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Colloidal quantum dots (QDs) have been broadly applied as fluorescent labeling materials in the fields of bio-imaging, sensing, and detection, in which the optical performances and stability of the utilized QDs are vital. Despite significant efforts in developing such materials, it is still challenging to fabricate QDs with high photoluminescence quantum yields (PL QYs) while concurrently possessing high particle and optical stabilities, limiting the further development of QD-based biological labeling and detection techniques. Herein, we report a synthesis of giant CdSe/ZnS/CdZnS/ZnS core/shell QDs with an ultrathick shell (∼36 monolayers) and high PL QYs (>80%). We further employ the as-synthesized QDs for C-reactive protein detection, which reach nearly a 3-fold enhancement in detection sensitivity (∼0.41 ng/mL) and a 2-fold increase in shelf life, in comparison to the traditional thick-shell QDs (i.e., CdSe/CdS/ZnS core/shell QDs) or commercially available core/shell QDs. We postulate that the performance improvements in protein detection are due to the use of the developed core/shell QDs with high particle stability and PL QYs and large surface area (facilitating surface antibody coupling). Our study demonstrates the viability of applying high-quality core/shell QDs for protein detection with high sensitivity and accuracy.

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