2014
DOI: 10.1073/pnas.1414661111
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Type IV pili interactions promote intercellular association and moderate swarming of Pseudomonas aeruginosa

Abstract: Pseudomonas aeruginosa is a ubiquitous bacterium that survives in many environments, including as an acute and chronic pathogen in humans. Substantial evidence shows that P. aeruginosa behavior is affected by its motility, and appendages known as flagella and type IV pili (TFP) are known to confer such motility. The role these appendages play when not facilitating motility or attachment, however, is unclear. Here we discern a passive intercellular role of TFP during flagellar-mediated swarming of P. aeruginosa… Show more

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Cited by 73 publications
(75 citation statements)
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“…In many instances hyper-swarmers are poor twitchers [3739] arguing that these two processes are inversely regulated. We thus tested HsbD impact on twitching motility (Fig 5).…”
Section: Resultsmentioning
confidence: 99%
“…In many instances hyper-swarmers are poor twitchers [3739] arguing that these two processes are inversely regulated. We thus tested HsbD impact on twitching motility (Fig 5).…”
Section: Resultsmentioning
confidence: 99%
“…The adhesion of Gram-negative bacteria to surfaces is largely dependent on the presence of cellular appendages such as flagella, pili and fimbriae [34,35]. Functional flagella enable the bacterium to swim and this ability is often required for surface colonization.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, a detailed computational model was used to study how quickly outer membrane (OM)-protein could spread throughout the populations of M. xanthus A+S− mutants with different physical and behavioral properties of individual cells at the swarm edge. Cells at the swarm edge are monolayered, exposed to a maximum level of nutrient and oxygen and behave distinctively compared to the interior cells [13, 46, 47]. The optimal rate of cell-cell connections and efficiency of protein transfer was obtained for reversal periods in the range from 4 to 12 minutes observed in experiments.…”
Section: Discussionmentioning
confidence: 99%