Abstract:Helix N-capping motifs often form hydrogen bonds with terminal amide groups which otherwise would be free. Also, without an amide hydrogen, proline (trans) is over-represented at helix N-termini (N1 position) because this naturally removes the need to hydrogen bond one terminal amide. However, the preference of cisPro, vis-à-vis helix N-termini, is not known. We show that cisPro (α or PP ) often appears at the N-cap position (N0) of helices. The N-cap cisPro(α ) is associated with a six-residue sequence motif … Show more
Replacement of a single residue in a β-hairpin by Gly-Pro, a ‘united-residue' known to be overrepresented in protein β-sheets as Gly-cisPro without causing much structural distortion, and comparison of the...
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