Types of fatigue in sarcoidosis patients

Kleijn, Willemien P. E. De; Drent, Marjolein; Vermunt, Jeroen K.; Shigemitsu, Hide; Vries, Jolanda De

doi:10.1016/j.jpsychores.2011.09.006

Cited by 26 publications

(30 citation statements)

References 35 publications

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“…Fatigue was the most frequent symptom reported by patients with sarcoidosis of different degrees of activity [3]. Research carried out in Germany on 1,197 patients showed that nearly 62% of men and 74% of women complained of fatigue [18]. Korenromp et al in the Netherlands examined 75 patients with sarcoidosis, and 76% of them reported fatigue in the course of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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Fatigue in patients with inactive sarcoidosis does not correlate with lung ventilation ability or walking distance. Pilot StudyZmęczenie u chorych z nieaktywną sarkoidozą nie koreluje ze zdolnością wentylacyjną płuc oraz z dystansem chodu. Badanie pilotażoweThe work has been conducted under a grant from the Silesian Medical University: project No. KNW-1-025/D/2/0 Abstract Introduction: Fatigue is one of many symptoms reported by patients with sarcoidosis. It is believed that fatigue may be the cause of exercise intolerance and reduced quality of life in patients with sarcoidosis. The purpose of the work was to present the frequency of fatigue prevalence in patients with sarcoidosis and to investigate the correlation between fatigue and the results of pulmonary function tests and walking distance. Material and methods: A total of 74 patients with sarcoidosis in a stable phase of the disease, not treated in the past with glucocorticoids or immunosuppressive drugs, and without indications for treatment at the time of the study were examined. In all patients fatigue evaluation was carried out with the use of the Fatigue Assessment Scale questionnaire (FAS); dyspnoea was assessed with the use of the Medical Research Council scale (MRC). Body Mass Index (BMI), spirometry, and a 6-minute walk test were additionally performed. The control group included 30 healthy volunteers who completed the FAS. Results: In the examined group of patients fatigue was diagnosed in 36 patients (50%), and in 5 (6.94%) -strong fatigue was observed. The remaining 31 (43.06%) patients felt no fatigue. The average value of points obtained by FAS questionnaire in sarcoidosis patients was significantly higher than the respective value in the control group (p = 0.02). A significantly higher number of points by FAS questionnaire was observed in female patients with sarcoidosis (p = 0.04) in comparison to men. No significant statistical correlation between fatigue index FAS and BMI (r = 0.22, p = 0.11), FEV 1 (r = -0.11, p = 0.3), FEV 1 % pred. (r = 0.01, p = 0.9), FVC (r = −0.03, p = 0.77), FEF 25−75 (r = −0.23, p = 0.1) and the distance in the six-minute walk test (6MWT) (r = −0.01, p = 0.9) was observed. However, there was a weak negative correlation between the age of the patients and the FAS index (r = −0.29, p = 0.01). Conclusions: Fatigue in patients with sarcoidosis does not correlate with the results of lung function tests or with walking distance in 6MWT.

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Section: Discussionmentioning

confidence: 99%

“…In the research by Miller [18,24], 67% of patients stopped during the test due to "weakness of the lower extremities", www.pneumonologia.viamedica.pl…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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“…It has been determined that depressive symptoms are negatively associated with and affect patients' fatigue scores [11,14,15]. In addition, the relationship between fatigue and depressive symptoms parallels the findings of other chronic illness, such as diabetes, chronic obstructive lung disease, cardiac disease and rheumatoid arthritis [41].…”

Section: Fatigue and Depressive Symptomsmentioning

confidence: 94%

“…Small fibre neuropathy SFN, a frequently bothersome symptom in a substantial number of sarcoidosis patients, can be linked to fatigue [11,56]. Although SFN may be difficult to diagnose, its identification can lead to possible targeted treatments, including TNF inhibitors [7,63] or intravenous immunoglobulin [64].…”

Section: Sleep Disturbancesmentioning

confidence: 99%

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Sarcoidosis-associated fatigue

Drent¹,

Lower²,

Vries³

2012

Eur Respir J

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221

182

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Sarcoidosis-associated fatigue is globally recognised as a disabling symptom. Fatigue has been reported in up to 50-70% of sarcoidosis patients, causing impaired quality of life. The aetiology of this troublesome problem remains elusive and is usually multifactorial. Fatigue can be a consequence of treatment itself, including as a complication of corticosteroid therapy. The diagnosis of sarcoidosis-associated fatigue requires an extensive evaluation to identify and treat potentially reversible causes. Granuloma formation and cytokine release may be involved in its aetiology. However, despite adequate sarcoidosis treatment, many patients continue to experience fatigue. Comorbidities associated with sarcoidosis, including depression, anxiety, hypothyroidism and altered sleep patterns, may all contribute to fatigue. Despite an exhaustive search for treatable clinical causes of fatigue, most patients' complaints of fatigue are not correlated with clinical parameters of disease activity. Recent studies have demonstrated the effectiveness of various neurostimulants, including methylphenidate, for the treatment of sarcoidosis-associated fatigue. These and other agents may be useful adjuncts for the treatment of sarcoidosis-associated fatigue. Obviously, there is a need for studies evaluating the causes and new therapeutic options of sarcoidosis-associated fatigue. Psychological interventions should also be examined.

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Physical Functioning and Symptoms of Chronic Fatigue in Sarcoidosis Patients

Pilzak

Żebrowska

Sikora

et al. 2017

Advances in Experimental Medicine and Biology

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Scientific reports underscore the importance of measuring the health-related quality of life in sarcoidosis patients. The present study seeks to define how sarcoidosis patients' quality of life, daily physical activity, and physical performance are related to each other. Seventeen patients (mean age 46.8 ± 8.8 years) suffering from sarcoidosis completed the following questionnaires: the fatigue assessment scale (FAS), the quality of life scale (SF-36 questionnaire), and the Borg dyspnea scale. Physical activity (PA) was assessed using accelerometry. Respiratory function, consisting of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory volume in one second as a percentage of vital capacity (FEV1/%FVC), and diffusing capacity of the lungs for carbon monoxide (DL), were assessed. In addition, performance in 6-min walk test (MWT), aerobic capacity assessed from maximal oxygen uptake (VOmax), and the metabolic equivalent of task (MET) were evaluated. We found that daily PA (4566 ± 2378 steps/day) and VOmax (21.8 ± 5.9 ml/kg/min) were lower in sarcoidosis patients than the known predicted values in healthy age-matched individuals. There were significant inverse associations between the FAS score and 6MWT (r = -0.62; p < 0.01), and between SF-36 score and 6MWT (r = -0.55; p < 0.03). In contrast, SF-36 scores associated with fatigue and dyspnea scores (r = 0.72; p < 0.001 and r = 0.85; p < 0.001). These findings imply that sarcoidosis patients are less active compared with healthy subjects. The FAS and SF-36 scales seem to be effective tools for assessing the severity of fatigue in sarcoidosis patients.

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Types of fatigue in sarcoidosis patients

Cited by 26 publications

References 35 publications

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Sarcoidosis-associated fatigue

Physical Functioning and Symptoms of Chronic Fatigue in Sarcoidosis Patients

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