Typhlitis in Children With Malignancy

Abstract

In a case-control study, medical records of all children (below 18 y of age) who were diagnosed with any malignancy between January 1988 and December 2008 were reviewed. Children who developed typhlitis during the course of their malignancy were identified. Age and sex-matched controls who were diagnosed with malignancy during the same time period but did not develop typhlitis were identified (1:4 ratio). The variables that were examined included underlying malignancy, chemotherapy, and final outcome. A total of 410 children (226 males, mean age of 87.29 ± 56.8 mo) with malignancy were recruited. Nine children (0.22%) (4 boys, mean age of 87.56 ± 60.48 mo) developed typhlitis during the course of their disease. In the control group, 36 age and sex-matched children were included (mean age of 87.67 ± 57.91 mo). Children who had Clostridium difficile infection within 8 weeks before developing typhlitis were more likely to develop typhlitis compared with controls (odds ratio 7.99, 95% confidence interval 1.46-43.7, P=0.01). One patient died from typhlitis. Clostridium difficile infection is a risk factor for developing typhlitis in children with cancer. Larger multicenter trials are needed to confirm our conclusions.

Neutropenic Enterocolitis: Case report and literature review

“…Those are Neutropenia < 500/mm 3 , fever > 38 degrees, wall thickness (ultrasound or CT) more than 4 mm, and abdominal pain. (16) Patients with neutropenic enterocolitis can present different degrees of neutropenia. In the study by Bautista it was observed that 80% of cases of neutropenic enterocolitis presented severe neutropenia (Less than 500 mm 3 ), 15% moderate neutropenia (Less than 1000 mm3) and the remaining 5% mild neutropenia (Less than 1500 mm 3 ) (5) .…”

Outcome and Determinants of Neutropenic Enterocolitis in Pediatric Cancer Patients

“…The incidence of NEC has varied greatly across the studies 8–10. There were no studies regarding NEC in India.…”

“…The incidence of NEC has varied greatly across the studies. [8][9][10] There were no studies regarding NEC in India. Hence, a pilot study was planned to include the eligible population receiving chemotherapy at the center during the study period as the study population, which served as the denominator for the calculation of incidence.…”

“…Hence, ultrasonography and computed tomography abdomen have been used to supplement the diagnosis. Most retrospective analyses report the incidence of NEC from 1.7% to 16.2% 8–14. However, there is scant literature regarding the incidence of NEC in developing nations.…”

“…Most retrospective analyses report the incidence of NEC from 1.7% to 16.2%. [8][9][10][11][12][13][14] However, there is scant literature regarding the incidence of NEC in developing nations.…”