Typing of herpes simplex virus from human periodontium

Contreras, Adolfo; Slots, J.

doi:10.1034/j.1399-302x.2001.160111.x

Cited by 26 publications

(23 citation statements)

References 14 publications

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“…When CMV was present, the copy numbers were low. The low prevalence and low copy number of CMV at periodontal sites in our patient population is consistent with the very low prevalence of CMV in chronic periodontitis (0%–0.3%) reported by others (Dawson et al, ; Nibali et al, ; Rotola et al, ) and questions the role of CMV in periodontal disease, despite the findings from several cross‐sectional studies indicating otherwise (Chalabi et al, ; Contreras & Slots, ; Grenier, Gagnon, & Grenier, ; Imbronito, Okuda, Maria de Freitas, Moreira Lotufo, & Nunes, ; Saygun, Kubar, Ozdemir, & Slots, ; Saygun, Yapar, Ozdemir, Kubar, & Slots, ; Slots, Kamma, & Sugar, ; Yapar, Saygun, Ozdemir, Kubar, & Sahin, ). It should be noted that a reason for the inconsistent prevalence of HHVs in periodontal sites described in the literature likely relates to the variability in the methodologies employed.…”

Section: Discussionsupporting

confidence: 91%

Relationship between herpesviruses and periodontal disease progression

Emecen‐Huja

Danaher

Dawson

et al. 2020

J Clinic Periodontology

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Aim To investigate the role of Epstein–Barr virus (EBV), cytomegalovirus (CMV), and anaerobic bacteria in the progression of periodontitis. Methods Eighty‐one adults with generalized moderate to severe periodontitis were randomly assigned to: oral hygiene or scaling and root planning ± placebo or polyunsaturated fatty acids fish oil. Subgingival plaque samples collected from three healthy and three disease sites at weeks 0, 16, and 28 and from sites demonstrating disease progression were analysed for EBV, CMV, P. gingivalis (Pg), T. forsythia (Tf), and T. denticola (Td) DNA using quantitative polymerase chain reaction. Results Cytomegalovirus was detected in 0.3% (4/1454) sites. EBV was present in 12.2% of healthy sites (89/728) and 27.6% disease sites (201/726; p < .0001), but was in low copy number. Disease progression occurred in 28.4% of participants (23/81) and developed predominantly at sites identified as diseased (75/78; 96.2%). CMV and EBV were not associated with disease progression (p = .13) regardless of treatment. In contrast, disease sites were associated with higher levels of Pg, Td, Tf, and total bacteria, and sites that exhibited disease progression were associated with an abundance of Td and Tf (p < .04). Conclusion Disease progression was associated with Gram‐negative anaerobic bacteria; not EBV or CMV.

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Section: Discussionsupporting

confidence: 91%

Relationship between herpesviruses and periodontal disease progression

Emecen‐Huja

Danaher

Dawson

et al. 2020

J Clinic Periodontology

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“…In our study, HSV-2 was not found to be statistically significant. Similar results were observed in the study by Contreras and Slots,[16] wherein presence of HSV-1 was seen in all the samples but HSV-2 was not detected in any of the samples. HSV-2 is usually transmitted through genital infection and is rarely found in the oral cavity.…”

Section: Discussionsupporting

confidence: 91%

“…In this study, EBV-1, HCMV, and HSV-2 have not shown any correlation with the clinical parameters of periodontal disease. However, studies conducted by Contreras and Slots et al .,[16] Ling et al .,[23] and Kamma et al .,[20] have found contradictory results.…”

Section: Discussionmentioning

confidence: 99%

Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters

Das

Krithiga

Gopalakrishnan

2012

J Oral Maxillofac Pathol

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Background and Aims:Recent microbiological researches have revealed the possible role of human cytomegalovirus (HCMV), Epstein barr virus (EBV), and herpes simplex virus (HSV-1 and HSV-2) in the etiopathogenesis of periodontal diseases. The present pilot study has been undertaken to detect the presence of these viruses in chronic periodontitis, aggressive periodontitis, and healthy individuals and to determine the relationship between these viruses and the clinical parameters.Materials and Methods:A total of 10 patients belonging to the age group of 18 to 55 years were included. The patients were randomly assigned into periodontally healthy (sulcus depth ≤ 3 mm), chronic periodontitis, and aggressive periodontitis with pockets measuring ≥6 mm. Seventy-five subgingival plaque samples (25 samples from each group) were collected and subjected to multiplex polymerase chain reaction for the detection of presence of HCMV, EBV, HSV-1, and HSV-2. The results were analyzed using one-way ANOVA for multiple group comparisons followed by Student's t-test for pair-wise comparisons. Categorical data was analyzed by Fisher's exact test.Results:HSV-1 was detected in 76% (P<0.001) of sites with chronic periodontitis and 80% (P<0.001) sites with aggressive periodontitis. EBV was detected in 32% (P<0.05) of sites with chronic periodontitis and aggressive periodontitis. The probing pocket depth and clinical attachment level was statistically significant in HSV-1 detected sites compared with undetected sites in aggressive periodontitis patientsConclusion:Among these viruses HSV-1 and EBV were found to be significantly associated with destructive periodontal disease, including chronic and aggressive periodontitis. Further, HSV-1 was found to be associated with severity and progression of destructive periodontal disease.

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“…In patients with periodontal disease, the herpes simplex virus was frequently detected in gingival crevicular fluid and in gingival biopsies of periodontal lesions (100,101). In patients with periodontal disease, the herpes simplex virus was frequently detected in gingival crevicular fluid and in gingival biopsies of periodontal lesions (100,101).…”

Section: Virusesmentioning

confidence: 99%

The endo‐perio lesion: a critical appraisal of the disease condition

Rotstein¹,

Simon²

2006

Endodontic Topics

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Endodontic–periodontal lesions present challenges to the clinician as far as diagnosis and prognosis of the involved teeth are concerned. Etiologic factors such as bacteria, fungi, and viruses as well as various contributing factors such as trauma, root resorptions, perforations, and dental malformations play an important role in the development and progression of such lesions. Treatment and prognosis of endodontic–periodontal diseases vary and depend on the cause and the correct diagnosis of each specific condition. This article will appraise the interrelationship between endodontic and periodontal diseases and provide biological and clinical evidence of significance for diagnosis, prognosis, and decision‐making in the treatment of these conditions.

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Typing of herpes simplex virus from human periodontium

Cited by 26 publications

References 14 publications

Relationship between herpesviruses and periodontal disease progression

Relationship between herpesviruses and periodontal disease progression

Detection of human herpes viruses in patients with chronic and aggressive periodontitis and relationship between viruses and clinical parameters

The endo‐perio lesion: a critical appraisal of the disease condition

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