Tyrosinase, elastase, hyaluronidase, inhibitory and antioxidant activity of Sri Lankan medicinal plants for novel cosmeceuticals

Liyanaarachchi, Gavini Dilkhushi; Samarasekera, Jayanetti Koralalage Ramani Radhika; Mahanama, K.R.R.; Hemalal, Kirihettiliyanage Don Patrick

doi:10.1016/j.indcrop.2017.11.019

Cited by 127 publications

(106 citation statements)

References 52 publications

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“…Quercetin is a flavonoid compound, widely available in various plants, which inhibits elastase activity. The resulting quercetin IC 50 of 200.003 µg/mL was slightly different compared to a previous study (221.69 µg/mL) [26]. This was due to different test conditions.…”

Section: Elastase Proteolytic Activity Inhibition Test On the Positivcontrasting

confidence: 73%

Elastase Activity Inhibition by the Most Active Fraction of Star Fruit (Averrhoa Carambola L.) Leaves From Three West Java Regions

2020

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Objective: Premature skin aging is caused by increased elastase proteolytic activity, which causes elastin breakdown and disorganization in connectivetissue, reducing elasticity and flexibility, and wrinkling skin. Natural compounds in plants, especially polyphenols, inhibit elastase proteolyticactivity and prevent premature skin aging. Star fruit (Averrhoa carambola L.) leaves contain many polyphenols with antioxidant, anti-inflammatory,hypoglycemic, and antimicrobial activities. However, no studies have shown that A. carambola leaves inhibit elastase proteolytic activity.Methods: This study tested the inhibition of elastase proteolytic activity by the water fractions (WF), ethyl acetate fractions, and n-hexane fractionsof A. carambola leaves from the Depok, Sukabumi, and Subang regions of West Java. Each fraction was tested using a microplate reader, and the totalphenolic and flavonoid content was determined for the most active fraction.Results: The WF of the A. carambola leaves from Depok was the most active fraction, with a half-maximal inhibitory concentration of 160.36 μg/mL.The total phenolic and flavonoid content in the WF was 115.68 mg gallic acid equivalent/g extract and 9.15 mg quercetin equivalent/g extract,respectively.Conclusion: The WF of A. carambola leaves is a natural material that may inhibit elastase proteolytic activity and prevents premature skin aging.

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Section: Elastase Proteolytic Activity Inhibition Test On the Positivcontrasting

confidence: 73%

Elastase Activity Inhibition by the Most Active Fraction of Star Fruit (Averrhoa Carambola L.) Leaves From Three West Java Regions

2020

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“…The cosmetics industry currently uses an array of plants, mostly belonging to the Asteraceae, Lamiaceae, Fabaceae, Poaceae, Malvaceae, and Rosaceae families [2]. Furthermore, studies are being conducted among native Canadian, Sri Lankan, and African plant species to find new ingredients [15][16][17].…”

Section: Cosmeceutical Developmentmentioning

confidence: 99%

Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications

Espinosa-Leal

García‐Lara

2019

Planta Med

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Cosmeceuticals are designed to serve a dual purpose: to provide desired esthetical effects and to treat dermatological conditions. Natural products derived from plants and marine organisms are a novel source of potential cosmeceutical active ingredients for incorporation into new formulations due to consumer demands. Contrary to common perceptions, most regulatory agencies do not view cosmeceuticals as being a separate category from cosmetics; thus, these products are not regulated accordingly, thereby forcing the consumer to rely on the self-regulatory policies of the cosmetics industry. Cosmeceuticals are advertised as having capabilities that include anti-aging, anti-acne, solar-protective, wound healing, and skin whitening. Such traits normally comprise several biological activities. In order to ensure the safety and efficacy of these products, active ingredients employed in the formulations must undergo a series of tests. In this review, in vitro (enzymatic and cellular) and in vivo tests employed to evaluate the potential of new cosmeceutical active ingredients are discussed, and new trends that are being explored by the cosmeceutical industry are described.

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“…The capacity of elastase and tyrosinase enzymatic inhibition of the studied extracted samples were conducted by an external service following the indications reported with slight modifications by Liyanaarachchi et al [31] and Chiari et al [32], respectively.…”

Section: Capacity Of Elastase and Tyrosinase Enzymatic Inhibitionmentioning

confidence: 99%

Microwave Hydrodiffusion and Gravity (MHG) Extraction from Different Raw Materials with Cosmetic Applications

et al. 2019

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Microwave hydrodiffusion and gravity (MHG) and ethanolic solid-liquid extraction were compared using selected plant sources. Their bioactive profile, color features, and proximate chemical characterization were determined. MHG extracts, commercial antioxidants, and three distinct types of thermal spring water were used in a sunscreen cream formulation. Their bioactive capacity, chemical and rheological properties were evaluated. MHG Cytisus scoparius flower extract provided the highest bioactive properties. Pleurotus ostreatus MHG liquor exhibited the highest total solid extraction yield. The Brassica rapa MHG sample stood out for its total protein content and its monosaccharide and oligosaccharide concentration. Quercus robur acorns divided into quarters supplied MHG extract with the lowest energy requirements, highest DPPH inhibition percentage, total lipid content and the highest enzyme inhibition. The chemical and bioactive capacities stability of the sunscreen creams elaborated with the selected MHG extracts and the thermal spring waters showed a similar behavior than the samples containing commercial antioxidants.

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Tyrosinase, elastase, hyaluronidase, inhibitory and antioxidant activity of Sri Lankan medicinal plants for novel cosmeceuticals

Cited by 127 publications

References 52 publications

Elastase Activity Inhibition by the Most Active Fraction of Star Fruit (Averrhoa Carambola L.) Leaves From Three West Java Regions

Elastase Activity Inhibition by the Most Active Fraction of Star Fruit (Averrhoa Carambola L.) Leaves From Three West Java Regions

Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications

Microwave Hydrodiffusion and Gravity (MHG) Extraction from Different Raw Materials with Cosmetic Applications

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